| Entry |
|
| Name |
pyruvate dehydrogenase (quinone);
pyruvate dehydrogenase;
pyruvic dehydrogenase;
pyruvic (cytochrome b1) dehydrogenase;
pyruvate:ubiquinone-8-oxidoreductase;
pyruvate oxidase (ambiguous);
pyruvate dehydrogenase (cytochrome) (incorrect)
|
| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With a quinone or similar compound as acceptor
 |
| Sysname |
pyruvate:ubiquinone oxidoreductase
|
| Reaction(IUBMB) |
pyruvate + ubiquinone + H2O = acetate + CO2 + ubiquinol
|
| Reaction(KEGG) |
|
| Substrate |
|
| Product |
|
| Comment |
Flavoprotein (FAD) [1]. This bacterial enzyme is located on the inner surface of the cytoplasmic membrane and coupled to the respiratory chain via ubiquinone [2,3]. Does not accept menaquinone. Activity is greatly enhanced by lipids [4,5,6]. Requires thiamine diphosphate [7]. The enzyme can also form acetoin [8].
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| Pathway |
|
| Orthology |
| pyruvate dehydrogenase (quinone) |
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| Genes |
ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBL: | | EBE: | | ELF: | | ECOA: | | EFE: | | STY: | | STT: | | SEX: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SEE: | | SEW: | | SEA: | | SED: | | SEG: | | SEL: | | SET: | | SENJ: | | SES: | | SBG: | | YPE: | | YPK: | | YPA: | | YPN: | | YPM: | | YPP: | | YPG: | | YPZ: | | YPT: | | YPD: | | YPX: | | YPH: | | YPS: | | YPI: | | YPY: | | YPB: | | YEN: | | YEP: | | YEY: | | SFL: | | SFX: | | SFV: | | SFE: | | SSN: | | SSJ: | | SBO: | | SBC: | | SDY: | | ETA: | | EPY: | | EPR: | | EAM: | | EAY: | | EBI: | | ERJ: | | ENT: | | ENC: | | ENO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | ESA: | | CSK: | | CSZ: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CKO: | | CRO: | | SPE: | | SRR: | | SRS: | | SRA: | | SMAF: | | SMW: | | PMR: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | RAH: | | RAQ: | | RAA: | | PSI: | | MMK: | | ROR: | | EBF: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XOO: | | XOM: | | XOP: | | XOR: | | XCI: | | SML: | | SMT: | | BUJ: | | SMZ: | | FAU: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PPF: | | PPG: | | PPW: | | PPT: | | PPI: | | PPX: | | PST: | | PSB: | | PSP: | | PFL: | | PFO: | | PFS: | | PFE: | | PFC: | | PPZ: | | PMY: | | PMK: | | PSA: | | PSZ: | | PSR: | | PSJ: | | PBA: | | PFV: | | AVN: | | AVL: | | AVD: | | ACI: | | SBL: | | SBM: | | SBP: | | SBS: | | SBB: | | CBD: | | LLO: | | MMT: | | NOC: | | NWA: | | RPI: | | RPF: | | REU: | | RME: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPR: | | BPZ: | | BPQ: | | BVI: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BMU: | | BMJ: | | BCT: | | BXE: | | BPH: | | BPY: | | BGL: | | BUG: | | BGE: | | BGF: | | BGD: | | BYI: | | BUK: | | BPX: | | PNU: | | BPA: | | BBR: | | BBM: | | BBH: | | BPT: | | BAV: | | AXY: | | AAV: | | AAA: | | VAP: | | RTA: | | HSE: | | NIT: | | NII: | | NMU: | | EBA: | | GBM: | | GEO: | | ADE: | | ACP: | | ANK: | | MXA: | | MFU: | | CCX: | | SUR: | | SCL: | | MCI: | | MOP: | | SMK: | | SMQ: | | SMX: | | SMI: | | SMEG: | | SMEL: | | SMD: | | REC: | | RLG: | | RTR: | | BJA: | | BJU: | | BRA: | | BBT: | | BRS: | | RPB: | | RPT: | | NHA: | | AOL: | | AZC: | | MEX: | | MEA: | | MDI: | | MCH: | | MRD: | | MET: | | MPO: | | MNO: | | MSL: | | HMC: | | MSC: | | NPP: | | ACR: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | ALI: | | ABS: | | TMO: | | BCK: | | BAG: | | BBE: | | PPY: | | PPM: | | PPO: | | PTA: | | HOR: | | VPR: | | MPA: | | MAV: | | MIT: | | MIR: | | MIA: | | MID: | | MSM: | | MSG: | | MSA: | | MGI: | | MSP: | | MAB: | | MMV: | | MJL: | | MJD: | | MRH: | | MMM: | | MCB: | | CGL: | | CGB: | | CGU: | | CGT: | | CEF: | | CDI: | | CDP: | | CDH: | | CDT: | | CDE: | | CDR: | | CDA: | | CDZ: | | CDB: | | CDS: | | CDD: | | CDW: | | CDV: | | CJK: | | CUR: | | CUA: | | CAR: | | CKP: | | CPU: | | CPL: | | CPG: | | CPP: | | CPK: | | CPQ: | | CPX: | | CPZ: | | COR: | | COP: | | COD: | | COS: | | COI: | | COE: | | COU: | | CRD: | | CUL: | | CUC: | | CUE: | | CVA: | | CHN: | | CCN: | | NFA: | | NCY: | | NBR: | | RHA: | | RER: | | ROP: | | REQ: | | GBR: | | GPO: | | GOR: | | TPR: | | SRT: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | STRP: | | KSK: | | CMI: | | CMS: | | CMC: | | MTS: | | ART: | | AAU: | | ACH: | | AAI: | | APN: | | ARR: | | RSA: | | KRH: | | MLU: | | RMU: | | BCV: | | BFA: | | JDE: | | SKE: | | CFL: | | CFI: | | CGA: | | PAC: | | PAK: | | PAV: | | PAX: | | PAZ: | | PAW: | | PAD: | | PCN: | | PACC: | | PACH: | | PBO: | | PRA: | | NCA: | | KFL: | | NDA: | | NAL: | | TCU: | | SRO: | | FRI: | | FAL: | | NML: | | BSD: | | MMAR: | | SEN: | | SVI: | | AMD: | | AMN: | | AMM: | | PDX: | | AMI: | | SESP: | | SAQ: | | MAU: | | MIL: | | VMA: | | AMS: | | ASE: | | CAI: | | SNA: | | RXY: | | CWO: | | PUV: | | ACA: | | ACM: | | GMA: | | TSA: | | TRS: | | BTH: | | BFR: | | BFS: | | BFG: | | BXY: | | PDI: | | OSP: | | ASH: | | CPI: | | PSN: | | SHG: | | CHU: | | SLI: | | COC: | | ZPR: | | CAO: | | ASL: | | ORH: | | AMU: | | SACI: | | DMR: | | DPD: | | TTR: | | TAC: | | PTO: | | SSO: | | SOL: | | SAI: | | SACN: | | SACR: | | SIS: | | SIA: | | SIM: | | SID: | | SIY: | | SIN: | | SII: | | SIH: | | SIR: | | NGA: | | » show all
 |
| Reference |
|
| Authors |
Recny MA, Hager LP |
| Title |
Reconstitution of native Escherichia coli pyruvate oxidase from apoenzyme monomers and FAD. |
| Journal |
J. Biol. Chem. 257 (1982) 12878-86. |
| Reference |
|
| Authors |
Cunningham CC, Hager LP |
| Title |
Reactivation of the lipid-depleted pyruvate oxidase system from Escherichia coli with cell envelope neutral lipids. |
| Journal |
J. Biol. Chem. 250 (1975) 7139-46. |
| Reference |
|
| Authors |
Koland JG, Miller MJ, Gennis RB |
| Title |
Reconstitution of the membrane-bound, ubiquinone-dependent pyruvate oxidase respiratory chain of Escherichia coli with the cytochrome d terminal oxidase. |
| Journal |
Biochemistry. 23 (1984) 445-53. |
| Reference |
|
| Authors |
Grabau C, Cronan JE Jr |
| Title |
In vivo function of Escherichia coli pyruvate oxidase specifically requires a functional lipid binding site. |
| Journal |
Biochemistry. 25 (1986) 3748-51. |
| Reference |
|
| Authors |
Wang AY, Chang YY, Cronan JE Jr |
| Title |
Role of the tetrameric structure of Escherichia coli pyruvate oxidase in enzyme activation and lipid binding. |
| Journal |
J. Biol. Chem. 266 (1991) 10959-66. |
| Reference |
|
| Authors |
Chang YY, Cronan JE Jr |
| Title |
Sulfhydryl chemistry detects three conformations of the lipid binding region of Escherichia coli pyruvate oxidase. |
| Journal |
Biochemistry. 36 (1997) 11564-73. |
| Reference |
|
| Authors |
O'Brien TA, Schrock HL, Russell P, Blake R 2nd, Gennis RB |
| Title |
Preparation of Escherichia coli pyruvate oxidase utilizing a thiamine pyrophosphate affinity column. |
| Journal |
Biochim. Biophys. Acta. 452 (1976) 13-29. |
| Reference |
|
| Authors |
Bertagnolli BL, Hager LP |
| Title |
Role of flavin in acetoin production by two bacterial pyruvate oxidases. |
| Journal |
Arch. Biochem. Biophys. 300 (1993) 364-71. |
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |