KEGG   ENZYME: 1.2.7.5Help
Entry
EC 1.2.7.5                  Enzyme                                 
Name
aldehyde ferredoxin oxidoreductase;
AOR
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
aldehyde:ferredoxin oxidoreductase
Reaction(IUBMB)
an aldehyde + H2O + 2 oxidized ferredoxin = a carboxylate + 2 H+ + 2 reduced ferredoxin [RN:R07158]
Reaction(KEGG)
Substrate
aldehyde [CPD:C00071];
H2O [CPD:C00001];
oxidized ferredoxin [CPD:C00139]
Product
carboxylate [CPD:C00060];
H+ [CPD:C00080];
reduced ferredoxin [CPD:C00138]
Comment
This is an oxygen-sensitive enzyme that contains tungsten-molybdopterin and iron-sulfur clusters. Catalyses the oxidation of aldehydes (including crotonaldehyde, acetaldehyde, formaldehyde and glyceraldehyde) to their corresponding acids. However, it does not oxidize glyceraldehyde 3-phosphate [see EC 1.2.7.6, glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)]. Can use ferredoxin or methyl viologen but not NAD(P)+ as electron acceptor.
Pathway
Glycolysis / Gluconeogenesis
Pentose phosphate pathway
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K03738  
aldehyde:ferredoxin oxidoreductase
Genes
SBL: 
SPC: 
SSE: 
SPL: 
SHW: 
MAH: 
CYQ: 
AEH: 
RFR: 
PNA: 
AJS: 
Ajs_3944
DIA: 
Dtpsy_3293
MPT: 
Mpe_A2581
LCH: 
Lcho_1817
TIN: 
Tint_2646
THI: 
THI_3176(aor)
EBA: 
ebA5005
AZO: 
azo2930(aorA)
AZA: 
AZKH_1616(aorA)
TMZ: 
Tmz1t_2811
APP: 
CAP2UW1_0307
WSU: 
WS1844
SDL: 
Sdel_1699
SBA: 
Sulba_1777
GSU: 
GSU0910 GSU2191
GSK: 
KN400_0895 KN400_2138
GME: 
Gmet_1045(aorA) Gmet_2087(bamB-1) Gmet_2289
GUR: 
Gura_1195 Gura_2421 Gura_3269 Gura_3550
GLO: 
Glov_2231
GBM: 
Gbem_0312 Gbem_1352 Gbem_1444(bamB-1) Gbem_3341
GEO: 
Geob_0085 Geob_0212 Geob_0228 Geob_0260 Geob_0269 Geob_1875 Geob_3259
GEM: 
GM21_0304 GM21_0904 GM21_2810 GM21_2933
GEB: 
GM18_1209 GM18_1306 GM18_1821 GM18_1843 GM18_3212 GM18_3420
PCA: 
Pcar_0254(aorA-1) Pcar_2514
PPD: 
Ppro_0465 Ppro_0580 Ppro_0888
DVU: 
DVU0687 DVU1179(aor)
DVL: 
Dvul_1877 Dvul_2276
DVM: 
DvMF_1956 DvMF_2671
DVG: 
Deval_0631 Deval_1088
DDE: 
Dde_2460 Dde_2943
DDS: 
Ddes_1775
DDN: 
DND132_0701 DND132_1018 DND132_1032 DND132_2371 DND132_2395
DMA: 
DMR_02370 DMR_22700 DMR_22830 DMR_29360 DMR_35460
DSA: 
Desal_0517 Desal_1641 Desal_3753
DAS: 
Daes_1327 Daes_2605 Daes_3267
DAF: 
Desaf_0315 Desaf_1713 Desaf_2874
DHY: 
DESAM_20802 DESAM_22054
DPI: 
BN4_10136 BN4_11866 BN4_12047 BN4_20263
DBA: 
Dbac_2001 Dbac_2007 Dbac_2054 Dbac_2150 Dbac_2323 Dbac_2970 Dbac_3328
DRT: 
Dret_0081 Dret_0175 Dret_1842 Dret_2319
DPS: 
DP2476
DPR: 
Despr_1395 Despr_2090
DSF: 
UWK_00311 UWK_01369 UWK_01406
DOL: 
Dole_1771 Dole_2289 Dole_2501
DAL: 
Dalk_0704 Dalk_2424 Dalk_2768 Dalk_4476 Dalk_4694
DAT: 
HRM2_02020(aor1) HRM2_04880(aor2) HRM2_05270(aor3) HRM2_14310(aor4) HRM2_33750(aor6) HRM2_38620(aor7) HRM2_38700(aor8) HRM2_44080
DTO: 
TOL2_C00430(aor1) TOL2_C01300(aor2) TOL2_C03790(bamB1) TOL2_C04250(aor3) TOL2_C05660(aor4) TOL2_C07610(aor5) TOL2_C28110(aor6) TOL2_C39760(aor7) TOL2_C41450(aor8) TOL2_C43590(bamB3)
HOH: 
Hoch_5245
SAT: 
SYN_00140 SYN_00261 SYN_01377 SYN_01640 SYN_02419 SYN_03032
DTI: 
Desti_0167 Desti_1599 Desti_1912
SFU: 
Sfum_1080 Sfum_1479 Sfum_2287
HMR: 
Hipma_0789 Hipma_0834
RRU: 
Rru_A0313
RRF: 
F11_01580
MAG: 
amb1488 amb2922
AZL: 
AZL_b04690(aor)
ALI: 
AZOLI_p20536(aor1)
BSE: 
Bsel_2218
CAC: 
CA_C2018
CAE: 
SMB_G2050(aor)
CAY: 
CEA_G2033
CBO: 
CBO1935(aorA)
CBA: 
CLB_1874(aor)
CBH: 
CLC_1881(aor)
CBY: 
CLM_2153(aor)
CBL: 
CLK_1393(aor)
CBB: 
CLD_2688(aor)
CBI: 
CLJ_B2140(aor)
CBF: 
CLI_2002(aor)
CBM: 
CBF_1985(aor)
CBJ: 
H04402_01957
CLJ: 
CLJU_c20210
CLS: 
CXIVA_17090
CAD: 
Curi_c25040(aor)
CST: 
CLOST_0827
AMT: 
Amet_0699 Amet_3157 Amet_4643
STH: 
STH2886 STH3283
SWO: 
Swol_1703 Swol_1835
SLP: 
Slip_0711 Slip_1587 Slip_2101
DHD: 
Dhaf_2056
DRM: 
Dred_1830 Dred_2273
DCA: 
Desca_0853 Desca_1319 Desca_1670 Desca_1941
DKU: 
Desku_0164 Desku_0587 Desku_0621 Desku_0627 Desku_2946 Desku_2951 Desku_2982 Desku_3081 Desku_3230
DRU: 
Desru_1387
PTH: 
PTH_0610 PTH_0852 PTH_0921 PTH_2604 PTH_2897
DAU: 
Daud_0135 Daud_0279
TJR: 
TherJR_0856 TherJR_2264 TherJR_2501 TherJR_2507
DOR: 
Desor_1169 Desor_1285 Desor_2516 Desor_2521 Desor_3072
DMI: 
Desmer_1182 Desmer_2082
HMO: 
HM1_0998(aor)
ELM: 
ELI_0332 ELI_1752 ELI_3389
AWO: 
Awo_c12420(for)
TEX: 
Teth514_1380
THX: 
Thet_1521
TPD: 
Teth39_0850
TBO: 
Thebr_0872
TWI: 
Thewi_0375
CHY: 
CHY_0789(aor1) CHY_1329(aor2) CHY_1747(aor4)
MTA: 
Moth_0154 Moth_0722 Moth_2300
ADG: 
Adeg_1006 Adeg_1743
TPZ: 
Tph_c04180(aor1) Tph_c07080(aor2) Tph_c08220(aor3) Tph_c20350(aor5) Tph_c27630(aor6)
CSC: 
Csac_0969
ATE: 
Athe_0821
COB: 
COB47_0758
CHD: 
Calhy_1866
COW: 
Calow_0668
CKI: 
Calkr_1890
CKN: 
Calkro_1832
CLC: 
Calla_1292
TOC: 
Toce_0383
CPO: 
COPRO5265_0137 COPRO5265_1588
TNR: 
Thena_0949 Thena_1055 Thena_1703
NTH: 
Nther_0827 Nther_2055
HAS: 
Halsa_0727
AAR: 
Acear_0949 Acear_0977 Acear_1487 Acear_1517
KFL: 
Kfla_2116
SHI: 
Shel_24640
ELE: 
Elen_2089
SSM: 
Spirs_3566
SCC: 
Spico_1227
SBU: 
SpiBuddy_2787
SGP: 
SpiGrapes_2201
STR: 
Sterm_1112 Sterm_1677
IPO: 
Ilyop_1309
IPA: 
Isop_2935
TAI: 
Taci_0217 Taci_0474 Taci_0803
ACO: 
Amico_0167 Amico_1873
TLI: 
Tlie_0012 Tlie_0489 Tlie_1226 Tlie_1446 Tlie_1551 Tlie_1780 Tlie_1797 Tlie_1914
AMO: 
Anamo_0077 Anamo_0095 Anamo_1467 Anamo_1576 Anamo_1966
RRS: 
RoseRS_4359
RCA: 
Rcas_0715 Rcas_1863
CAU: 
Caur_1533
CAG: 
Cagg_1166 Cagg_2271
CHL: 
Chy400_1666
HAU: 
Haur_3590
TRO: 
trd_A0661
STI: 
Sthe_3386
ATM: 
ANT_14670 ANT_16440 ANT_17220
CAP: 
CLDAP_12620(aor) CLDAP_22600
TTH: 
TTC1834
TTJ: 
TTHA0152
TTS: 
Ththe16_0233 Ththe16_0380
TTL: 
TtJL18_1700 TtJL18_1872
TSC: 
TSC_c00500(aor) TSC_c12760
THC: 
TCCBUS3UF1_12120 TCCBUS3UF1_20860
TOS: 
Theos_0390 Theos_1851
OPR: 
Ocepr_0207 Ocepr_2171
HTH: 
HTH_1132(aor)
HTE: 
Hydth_1124
TAL: 
Thal_0420
TLE: 
Tlet_0469 Tlet_1346
TTA: 
Theth_0853 Theth_1019
PMO: 
Pmob_0381
KOL: 
Kole_1088
MPZ: 
Marpi_1140
TYE: 
THEYE_A0109 THEYE_A0591 THEYE_A1699
DDF: 
DEFDS_0764
FSI: 
Flexsi_1401
TID: 
Thein_2108 Thein_2110
CEX: 
CSE_00260(aor)
MOX: 
DAMO_2797(aor)
MAC: 
MA1714 MA2962 MA3989(aor)
MBA: 
Mbar_A0696
MMA: 
MM_0921 MM_2645 MM_3326
MMAZ: 
MmTuc01_0943 MmTuc01_2710 MmTuc01_3431
MEV: 
Metev_1385 Metev_1807
MZH: 
Mzhil_0751
MPY: 
Mpsy_1578
MHZ: 
Metho_0168
MTP: 
Mthe_0900
MHI: 
Mhar_2265
MHU: 
Mhun_1005
MLA: 
Mlab_0187 Mlab_0396
MEM: 
Memar_0339
MPL: 
Mpal_1563
MPD: 
MCP_0618 MCP_0658
MEZ: 
Mtc_1223(aor-1) Mtc_2235(aor-2)
RCI: 
RCIX2090(aor-1) RRC230(aor-2)
AFU: 
AF0023(aor-1) AF0077(aor-2) AF0340(aor-3) AF2281(aor-4)
APO: 
Arcpr_0080 Arcpr_1332
AVE: 
Arcve_0051 Arcve_1916
FPL: 
Ferp_1026 Ferp_1232 Ferp_1307 Ferp_1422 Ferp_1488 Ferp_2103 Ferp_2334
HMA: 
rrnAC1318(aor2) rrnAC2064(aor1)
HHI: 
HAH_1907(aor1) HAH_2534(aor2) HAH_2557(aor3)
NPH: 
NP1432A(aor_2) NP4964A(aor_1) NP5016A(aor_4) NP6186A(aor_3)
NMO: 
Nmlp_1571(aor3) Nmlp_3660(aor2) Nmlp_3663(aor1)
HLA: 
Hlac_1050 Hlac_1370 Hlac_1464
HTU: 
Htur_0387 Htur_0664 Htur_0687 Htur_2361 Htur_4067 Htur_4718 Htur_4742
NMG: 
Nmag_2118 Nmag_2661 Nmag_3867
HVO: 
HVO_2183(aor4) HVO_B0244(aor1) HVO_B0256(aor3)
HME: 
HFX_2008(aor_3) HFX_2242(aor1)
HJE: 
HacjB3_04120 HacjB3_04725 HacjB3_14990
HBO: 
Hbor_06240 Hbor_26060 Hbor_31050
HXA: 
Halxa_0608 Halxa_1711 Halxa_3743 Halxa_4222
NAT: 
NJ7G_3998
NPE: 
Natpe_2115 Natpe_3174 Natpe_3597
NGE: 
Natgr_0016 Natgr_1073 Natgr_1265 Natgr_2925 Natgr_3276
NOU: 
Natoc_0227 Natoc_0900 Natoc_2097 Natoc_2929
TAC: 
Ta0810 Ta0834
TVO: 
TVN0795 TVN1239
PHO: 
PH0028 PH0892 PH1019 PH1274
PAB: 
PAB0647(aor-2) PAB0798(for) PAB2085(aor-1) PAB2330(aor-3)
PFU: 
PF0346 PF1203 PF1961
PFI: 
PFC_00810 PFC_05225 PFC_06635 PFC_08775
PYN: 
PNA2_0553 PNA2_1543 PNA2_1850
PYA: 
PYCH_05360 PYCH_06880 PYCH_09430
PYS: 
Py04_0091 Py04_0868 Py04_1188
TKO: 
TK0844 TK1066
TON: 
TON_0444 TON_0749 TON_1354 TON_1807
TGA: 
TGAM_0734(aor-1) TGAM_1913(aor-4)
TSI: 
TSIB_0476 TSIB_1009 TSIB_1133 TSIB_1619
TBA: 
TERMP_00788 TERMP_01323 TERMP_02145
THE: 
GQS_02990 GQS_04210 GQS_04540
THA: 
TAM4_178 TAM4_573
THM: 
CL1_0239 CL1_1348
ABI: 
Aboo_0812 Aboo_1115 Aboo_1343 Aboo_1540
ACF: 
AciM339_0264 AciM339_1442 AciM339_1502
APE: 
APE_0266.1(aor)
SMR: 
Smar_0668 Smar_1199
SHC: 
Shell_0125 Shell_0845 Shell_1268
IHO: 
Igni_0025 Igni_1032
DKA: 
DKAM_0593 DKAM_0975
DMU: 
Desmu_0114
DFD: 
Desfe_0695 Desfe_1093
TAG: 
Tagg_0105 Tagg_0120 Tagg_0448
THG: 
TCELL_0599
HBU: 
Hbut_0351 Hbut_0737 Hbut_1001 Hbut_1553
PFM: 
Pyrfu_1589 Pyrfu_1808
PAI: 
PAE0622 PAE2052 PAE3427
PIS: 
Pisl_0738 Pisl_0970
PCL: 
Pcal_0077 Pcal_0204 Pcal_1040 Pcal_2057
PAS: 
Pars_1164 Pars_1880 Pars_2092 Pars_2285
PYR: 
P186_0602 P186_2141
POG: 
Pogu_0032 Pogu_0250 Pogu_1085 Pogu_2583
CMA: 
Cmaq_0005 Cmaq_0260 Cmaq_0338 Cmaq_0710 Cmaq_1137
TNE: 
Tneu_1310 Tneu_1927
TUZ: 
TUZN_1735 TUZN_2158
TTN: 
TTX_1294(aor-2) TTX_1396(for) TTX_1768(aor-3)
VDI: 
Vdis_0035 Vdis_0074 Vdis_0495 Vdis_2192
VMO: 
VMUT_0586 VMUT_0922 VMUT_0955 VMUT_1163 VMUT_1175 VMUT_1242
TPE: 
Tpen_0094 Tpen_0176 Tpen_1413 Tpen_1817
ASC: 
ASAC_0698 ASAC_0762 ASAC_1249 ASAC_1295
CLG: 
Calag_0264 Calag_0832 Calag_1143
FFO: 
FFONT_0196 FFONT_0226 FFONT_0604 FFONT_0909
KCR: 
Kcr_0013 Kcr_0257 Kcr_0275 Kcr_0779 Kcr_0921 Kcr_1084
HAH: 
Halar_1250 Halar_1665 Halar_2177 Halar_2238 Halar_3117
 » show all
Taxonomy
Reference
1  [PMID:1907273]
  Authors
Mukund S, Adams MW.
  Title
The novel tungsten-iron-sulfur protein of the hyperthermophilic archaebacterium, Pyrococcus furiosus, is an aldehyde ferredoxin oxidoreductase. Evidence for its participation in a unique glycolytic pathway.
  Journal
J. Biol. Chem. 266 (1991) 14208-16.
  Organism
Pyrococcus furiosus [GN:pfu]
Reference
2  [PMID:8444863]
  Authors
Johnson JL, Rajagopalan KV, Mukund S, Adams MW.
  Title
Identification of molybdopterin as the organic component of the tungsten cofactor in four enzymes from hyperthermophilic Archaea.
  Journal
J. Biol. Chem. 268 (1993) 4848-52.
  Organism
Pyrococcus furiosus [GN:pfu]
Reference
3  [PMID:7878465]
  Authors
Chan MK, Mukund S, Kletzin A, Adams MW, Rees DC.
  Title
Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase.
  Journal
Science. 267 (1995) 1463-9.
  Organism
Pyrococcus furiosus [GN:pfu]
Reference
4  [PMID:11265456]
  Authors
Roy R, Menon AL, Adams MW.
  Title
Aldehyde oxidoreductases from Pyrococcus furiosus.
  Journal
Methods. Enzymol. 331 (2001) 132-44.
  Organism
Pyrococcus furiosus [GN:pfu]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
138066-90-7
DBGET integrated database retrieval system