KEGG   ENZYME: 1.2.7.6Help
Entry
EC 1.2.7.6                  Enzyme                                 

Name
glyceraldehyde-3-phosphate dehydrogenase (ferredoxin);
GAPOR;
glyceraldehyde-3-phosphate Fd oxidoreductase;
glyceraldehyde-3-phosphate ferredoxin reductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase
Reaction(IUBMB)
D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin [RN:R07159]
Reaction(KEGG)
Substrate
D-glyceraldehyde-3-phosphate;
H2O [CPD:C00001];
oxidized ferredoxin [CPD:C00139]
Product
3-phospho-D-glycerate [CPD:C00197];
H+ [CPD:C00080];
reduced ferredoxin [CPD:C00138]
Comment
Contains tungsten-molybdopterin and iron-sulfur clusters. This enzyme is thought to function in place of glyceralde-3-phosphate dehydrogenase and possibly phosphoglycerate kinase in the novel Embden-Meyerhof-type glycolytic pathway found in Pyrococcus furiosus [1]. It is specific for glyceraldehyde-3-phosphate.
History
EC 1.2.7.6 created 2003
Pathway
Glycolysis / Gluconeogenesis
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K11389  
glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)
Genes
GUR: 
GSB: 
DOL: 
ATM: 
TAM: 
TOP: 
TCM: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MEV: 
PHO: 
PH0457(PH0457)
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TGA: 
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
TEU: 
TGY: 
THV: 
PPAC: 
SMR: 
SHC: 
IHO: 
IIS: 
DKA: 
DMU: 
DFD: 
TAG: 
IAG: 
THG: 
PFM: 
PDL: 
PAI: 
PIS: 
PCL: 
PAS: 
PYR: 
POG: 
TNE: 
CMA: 
TUZ: 
TTN: 
VDI: 
VMO: 
ASC: 
CLG: 
NAA: 
 » show all
Taxonomy
Reference
1  [PMID:7721730]
  Authors
Mukund S, Adams MW.
  Title
Glyceraldehyde-3-phosphate ferredoxin oxidoreductase, a novel tungsten-containing enzyme with a potential glycolytic role in the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J. Biol. Chem. 270 (1995) 8389-92.
  Sequence
[pfu:PF0464]
Reference
2  [PMID:11265456]
  Authors
Roy R, Menon AL, Adams MW.
  Title
Aldehyde oxidoreductases from Pyrococcus furiosus.
  Journal
Methods. Enzymol. 331 (2001) 132-44.
  Sequence
[pfu:PF0464]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
162995-20-2

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