KEGG   ENZYME: 1.2.99.5Help
Entry
EC 1.2.99.5                 Enzyme                                 

Name
formylmethanofuran dehydrogenase;
formylmethanofuran:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
formylmethanofuran:acceptor oxidoreductase
Reaction(IUBMB)
formylmethanofuran + H2O + acceptor = CO2 + methanofuran + reduced acceptor
Substrate
formylmethanofuran [CPD:C01001];
H2O [CPD:C00001];
acceptor [CPD:C00028]
Product
CO2 [CPD:C00011];
methanofuran [CPD:C00862];
reduced acceptor [CPD:C00030]
Comment
A molybdoprotein containing a pterin cofactor. Tungstate can substitute for molybdate. The enzyme catalyses a reversible reaction in methanogenic bacteria, and is involved in methanogenesis from CO2 as well as the oxidation of methyl-coenzyme M to CO2. Methylviologen can act as acceptor. Also oxidizes N-furfurylformamide.
History
EC 1.2.99.5 created 1992
Pathway
Metabolic pathways
Microbial metabolism in diverse environments
Reference
1  [PMID:2125267]
  Authors
Karrasch M, Borner G, Enssle M, Thauer RK.
  Title
The molybdoenzyme formylmethanofuran dehydrogenase from Methanosarcina barkeri contains a pterin cofactor.
  Journal
Eur. J. Biochem. 194 (1990) 367-72.
Reference
2  [PMID:8161283]
  Authors
Bertram PA, Schmitz RA, Linder D, Thauer RK
  Title
Tungstate can substitute for molybdate in sustaining growth of Methanobacterium thermoautotrophicum. Identification and characterization of a tungsten isoenzyme  of formylmethanofuran dehydrogenase.
  Journal
Arch. Microbiol. 161 (1994) 220-8.
Reference
3  [PMID:8125106]
  Authors
Bertram PA, Karrasch M, Schmitz RA, Bocher R, Albracht SP, Thauer RK
  Title
Formylmethanofuran dehydrogenases from methanogenic Archaea. Substrate specificity, EPR properties and reversible inactivation by cyanide of the molybdenum or tungsten iron-sulfur proteins.
  Journal
Eur. J. Biochem. 220 (1994) 477-84.
  Sequence
Reference
4  [PMID:9342247]
  Authors
Vorholt JA, Thauer RK
  Title
The active species of 'CO2' utilized by formylmethanofuran dehydrogenase from methanogenic Archaea.
  Journal
Eur. J. Biochem. 248 (1997) 919-24.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
119940-12-4

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