KEGG   ENZYME: 1.2.99.5Help
Entry
EC 1.2.99.5                 Enzyme                                 
Name formylmethanofuran dehydrogenase;
formylmethanofuran:(acceptor) oxidoreductase
Class Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With other acceptors
BRITE hierarchy
Sysname formylmethanofuran:acceptor oxidoreductase
Reaction(IUBMB) formylmethanofuran + H2O + acceptor = CO2 + methanofuran + reduced
acceptor [RN:R03015]
Reaction(KEGG) R03015
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Substrate formylmethanofuran [CPD:C01001];
H2O [CPD:C00001];
acceptor [CPD:C00028]
Product CO2 [CPD:C00011];
methanofuran [CPD:C00862];
reduced acceptor [CPD:C00030]
Cofactor Molybdenum [CPD:C00150];
Pterin [CPD:C00715]
Comment A molybdoprotein containing a pterin cofactor. Methyl viologen can
act as acceptor. Also oxidizes N-furfurylformamide.
Pathway PATH: ec00790  Folate biosynthesis
PATH: ec01100  Metabolic pathways
Orthology KO: K00200  formylmethanofuran dehydrogenase subunit A
KO: K00201  formylmethanofuran dehydrogenase subunit B
KO: K00202  formylmethanofuran dehydrogenase subunit C
KO: K00203  formylmethanofuran dehydrogenase subunit D
KO: K00204  formylmethanofuran dehydrogenase subunit H
KO: K00205  formylmethanofuran dehydrogenase subunit F
KO: K11260  formylmethanofuran dehydrogenase subunit G
KO: K11261  formylmethanofuran dehydrogenase subunit E
Genes MCA: MCA2859 MCA2860
NOC: Noc_0022 Noc_0024 Noc_0025
BXE: Bxe_B2461(fhcB) Bxe_B2462(fhcA) Bxe_B2464(fhcC)
BPH: Bphy_5934 Bphy_5935 Bphy_6504 Bphy_6505 Bphy_6507
VAP: Vapar_3066 Vapar_3067
MPT: Mpe_A2623 Mpe_A2624 Mpe_A2626
LCH: Lcho_3133 Lcho_3135 Lcho_3136
MFA: Mfla_1662 Mfla_1663 Mfla_1665
MMB: Mmol_0861 Mmol_0862
MEI: Msip34_1506 Msip34_1507
PCA: Pcar_0156(fwdE)
PPD: Ppro_1464
DDE: Dde_1625
DDS: Ddes_1508
SAT: SYN_00638 SYN_01060
SFU: Sfum_3700
XAU: Xaut_1795 Xaut_1796
MEX: Mext_1824 Mext_1826 Mext_1827
MEA: Mex_1p1757(fhcA) Mex_1p1758(fhcB)
MDI: METDI2507(fhcC) METDI2509(fhcA) METDI2510(fhcB)
MRD: Mrad2831_0523 Mrad2831_0525 Mrad2831_0526
MET: M446_5773 M446_5775 M446_5776
MPO: Mpop_1775 Mpop_1777 Mpop_1778
MCH: Mchl_2159 Mchl_2161 Mchl_2162
MNO: Mnod_5999 Mnod_6000
MSL: Msil_2400 Msil_2401
GBE: GbCGDNIH1_0778 GbCGDNIH1_0779 GbCGDNIH1_0781
SWO: Swol_1664
ABA: Acid345_0503
ACA: ACP_1857
SUS: Acid_6374
RBA: RB9834(fwdA) RB9836(fwdC)
CTE: CT1717
RRS: RoseRS_1795
RCA: Rcas_2175
CAU: Caur_0027
CAG: Cagg_3664
CHL: Chy400_0031
MJA: MJ0658 MJ1165 MJ1166 MJ1167 MJ1168 MJ1169 MJ1171 MJ1194m(fwdB)
MFE: Mefer_0153 Mefer_0155 Mefer_0243
MVU: Metvu_0799 Metvu_1491
MMP: MMP0070 MMP0200(fmdE) MMP0508(fmdE) MMP0509(fmdA) MMP0510(fmdC)
     MMP0511(fmdB) MMP0512(fmdB) MMP1244(fwdH) MMP1245(fwdF)
     MMP1246(fwdG) MMP1247(fwdD) MMP1248(fwdA) MMP1249(fwdC)
     MMP1691(fwdB)
MMQ: MmarC5_0342 MmarC5_0343 MmarC5_0344 MmarC5_0345 MmarC5_0346
     MmarC5_0347 MmarC5_1449 MmarC5_1450 MmarC5_1451 MmarC5_1452
     MmarC5_1607 MmarC5_1715
MMX: MmarC6_0380 MmarC6_0381 MmarC6_0382 MmarC6_0383 MmarC6_0980
     MmarC6_1424 MmarC6_1425
MMZ: MmarC7_0494 MmarC7_0495 MmarC7_0966 MmarC7_1529 MmarC7_1530
     MmarC7_1531 MmarC7_1532
MAE: Maeo_0082 Maeo_0083 Maeo_0084 Maeo_0085 Maeo_0100 Maeo_1442
     Maeo_1443 Maeo_1462
MVN: Mevan_0067 Mevan_0562 Mevan_0563 Mevan_0993 Mevan_1661
     Mevan_1662 Mevan_1663 Mevan_1664
MAC: MA0304(fmdE) MA0305(fmdF) MA0306(fmdA) MA0307(fmdC)
     MA0308(fmdD) MA0309(fmdB) MA0671(fwdG) MA0832(fwdC)
     MA0833(fwdA) MA0834(fwdB) MA0835(fwuD) MA1241(fmdB) MA2867
     MA2877(fwdG) MA2878(fwdB) MA2879(fwdD) MA4174(fmdF)
     MA4175(fmdA) MA4176(fmdC) MA4177(fmdD) MA4178(fmdB)
MBA: Mbar_A1287 Mbar_A1288 Mbar_A1289 Mbar_A1290 Mbar_A1291
     Mbar_A1292 Mbar_A1560 Mbar_A1763 Mbar_A2588 Mbar_A2921
     Mbar_A2922 Mbar_A2923
MMA: MM_0055 MM_0058 MM_0059 MM_0060 MM_1564 MM_1565(fmdF)
     MM_1566(fmdA) MM_1567(fmdC) MM_1568(fmdD) MM_1569(fmdB) MM_1824
     MM_1978 MM_1979 MM_1980 MM_1981
MBU: Mbur_0281 Mbur_0282 Mbur_0283 Mbur_0284 Mbur_0285 Mbur_0286
     Mbur_0335 Mbur_0336 Mbur_0337 Mbur_0553 Mbur_1478
MTP: Mthe_1098 Mthe_1575
MHU: Mhun_1835 Mhun_1981 Mhun_1982 Mhun_1983 Mhun_1984 Mhun_1985
     Mhun_1988 Mhun_1989 Mhun_1990 Mhun_2004 Mhun_2112
MLA: Mlab_0238 Mlab_0243 Mlab_0244 Mlab_0245 Mlab_0246 Mlab_0575
MEM: Memar_0370 Memar_0371 Memar_0372 Memar_0618 Memar_0619
     Memar_0620 Memar_0621 Memar_0626 Memar_1046 Memar_1187
MBN: Mboo_0591 Mboo_0875 Mboo_0876 Mboo_0877 Mboo_1309 Mboo_1471
     Mboo_1473 Mboo_2359
MPL: Mpal_0201 Mpal_0202 Mpal_0203 Mpal_1589 Mpal_2233 Mpal_2234
     Mpal_2235
MPD: MCP_1572(fwdA-1) MCP_1573(fwdB-1)
MTH: MTH1553 MTH1554 MTH1555 MTH1556 MTH1557 MTH1558 MTH1559 MTH238
     MTH917 MTH918 MTH919 MTH926
MST: Msp_0241(fwdG) Msp_0242(fwdD) Msp_0243(fwdB) Msp_0244(fwdA)
     Msp_0245(fwdC)
MSI: Msm_0783 Msm_1396 Msm_1408 Msm_1409 Msm_1410 Msm_1411 Msm_1412
     Msm_1413 Msm_1414
MKA: MK0259(fwdB_1) MK0307(fwdF_1) MK0323(fwd_F2) MK1525(fwdG)
     MK1526(fwdD) MK1527(fwdB_2) MK1529(fwdA) MK1530(fwdC)
AFU: AF1644(fwdF) AF1649(fwdG) AF1650(fwdB-1) AF1928(fwdD-2)
     AF1929(fwdB-2) AF1930(fwdA) AF1931(fwdC)
RCI: RCIA24(fwdG-1) RCIX1639(fmdE) RCIX1641(fmdB) RCIX1642(fmdD)
     RCIX592(fwdF-1) RCIX598(fwdD-1) RCIX599(fwdB-1) RCIX600(fwdA-1)
     RCIX601(fwdC-1) RRC253(fwdG-2) RRC254(fwdF-2) RRC260(fwdD-2)
     RRC261(fwdB-2) RRC262(fwdA-2) RRC263(fwdC-2)
TPE: Tpen_1423
Taxonomy
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:2125267]
Karrasch M, Borner G, Enssle M, Thauer RK.
The molybdoenzyme formylmethanofuran dehydrogenase from
Methanosarcina barkeri contains a pterin cofactor.
Eur. J. Biochem. 194 (1990) 367-72.
Methanosarcina barkeri [GN:mba]
Other DBs ExplorEnz - The Enzyme Database: 1.2.99.5
IUBMB Enzyme Nomenclature: 1.2.99.5
ExPASy - ENZYME nomenclature database: 1.2.99.5
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.99.5
BRENDA, the Enzyme Database: 1.2.99.5
CAS: 119940-12-4
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