KEGG   ENZYME: 1.2.99.6Help
Entry
EC 1.2.99.6                 Enzyme                                 

Name
carboxylate reductase;
aldehyde:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With other, unknown, acceptors
BRITE hierarchy
Sysname
aldehyde:acceptor oxidoreductase
Reaction(IUBMB)
an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor [RN:R00544]
Reaction(KEGG)
Substrate
aldehyde [CPD:C00071];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product
carboxylate [CPD:C00060];
reduced acceptor [CPD:C00030]
Comment
A tungsten protein. Methyl viologen can act as acceptor. In the reverse direction, non-activated acids are reduced by reduced viologens to aldehydes, but not to the corresponding alcohols.
History
EC 1.2.99.6 created 1992
Pathway
Pyruvate metabolism
Reference
1  [PMID:2550230]
  Authors
White H, Strobl G, Feicht R, Simon H.
  Title
Carboxylic acid reductase: a new tungsten enzyme catalyses the reduction of non-activated carboxylic acids to aldehydes.
  Journal
Eur. J. Biochem. 184 (1989) 89-96.
  Organism
Moorella thermoacetica
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
125008-36-8

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