KEGG   ENZYME: 1.21.3.8Help
Entry
EC 1.21.3.8                 Enzyme                                 

Name
cannabidiolic acid synthase;
CBDA synthase
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With oxygen as acceptor
BRITE hierarchy
Sysname
cannabigerolate:oxygen oxidoreductase (cyclizing, cannabidiolate-forming)
Reaction(IUBMB)
cannabigerolate + O2 = cannabidiolate + H2O2 [RN:R10160]
Reaction(KEGG)
Substrate
cannabigerolate [CPD:C20406];
O2 [CPD:C00007]
Product
cannabidiolate [CPD:C10784];
H2O2 [CPD:C00027]
Comment
Binds FAD covalently. Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also convert cannabinerolate to cannabidiolate with lower efficiency.
History
EC 1.21.3.8 created 2012
Reference
1  [PMID:8663284]
  Authors
Taura F, Morimoto S, Shoyama Y
  Title
Purification and characterization of cannabidiolic-acid synthase from Cannabis sativa L.. Biochemical analysis of a novel enzyme that catalyzes the oxidocyclization of cannabigerolic acid to cannabidiolic acid.
  Journal
J. Biol. Chem. 271 (1996) 17411-6.
  Sequence
[up:A6P6V9]
Reference
2  [PMID:17544411]
  Authors
Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S
  Title
Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa.
  Journal
FEBS. Lett. 581 (2007) 2929-34.
  Sequence
[up:A6P6V9]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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