KEGG   ENZYME: 1.21.4.1Help
Entry
EC 1.21.4.1                 Enzyme                                 

Name
D-proline reductase (dithiol)
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With a disulfide as acceptor
BRITE hierarchy
Sysname
5-aminopentanoate:lipoate oxidoreductase (cyclizing)
Reaction(IUBMB)
5-aminopentanoate + lipoate = D-proline + dihydrolipoate
Reaction(KEGG)
(other) R02825
Show
Substrate
5-aminopentanoate [CPD:C00431];
lipoate [CPD:C00725]
Product
D-proline [CPD:C00763];
dihydrolipoate [CPD:C02147]
Comment
The reaction is observed only in the direction of D-proline reduction. Other dithiols can function as reducing agents; the enzyme contains a pyruvoyl group and a selenocysteine residue, both essential for activity.
History
EC 1.21.4.1 created 1972 as EC 1.4.4.1, modified 1982 (EC 1.4.1.6 created 1961, incorporated 1982), transferred 2003 to EC 1.21.4.1
Pathway
Arginine and proline metabolism
Orthology
K10793  
D-proline reductase (dithiol) PrdA
K10794  
D-proline reductase (dithiol) PrdB
K10795  
D-proline reductase (dithiol) PrdD
K10796  
D-proline reductase (dithiol) PrdE
Genes
GEB: 
SCU: 
BSE: 
GOT: 
LSJ: 
EHR: 
MPS: 
MPX: 
CBO: 
CBO2461(prdB1) CBO2464(prdA1) CBO2475(prdE) CBO2476(prdD) CBO2477(prdB2) CBO2480(prdA2)
CBA: 
CLB_2328(prdB) CLB_2330(prdA) CLB_2344(prdE) CLB_2345(prdD) CLB_2347(prdB) CLB_2349(prdA)
CBH: 
CBY: 
CBL: 
CLK_1840(prdB) CLK_1843(prdA) CLK_1856(prdE) CLK_1857(prdD) CLK_1858 CLK_1861(prdA) CLK_3047 CLK_3048(prdB-2)
CBB: 
CLD_2158(prdA) CLD_2160 CLD_2162(prdD) CLD_2163(prdE) CLD_2175(prdA) CLD_2177(prdB)
CBI: 
CLJ_B2691(prdA_1) CLJ_B2705 CLJ_B2707(prdA_2)
CBF: 
CBM: 
CBJ: 
CSQ: 
CLD: 
CCK: 
CTYK: 
AMT: 
AOE: 
CDF: 
PDC: 
CDC: 
CDL: 
CDG: 
PDF: 
CST: 
EAC: 
TOC: 
MED: 
SAPI: 
PBO: 
BTP: 
RRD: 
AYM: 
 » show all
Taxonomy
Reference
1  [PMID:5778643]
  Authors
Hodgins DS, Abeles RH.
  Title
Studies of the mechanism of action of D-proline reductase: the presence on covalently bound pyruvate and its role in the catalytic process.
  Journal
Arch. Biochem. Biophys. 130 (1969) 274-85.
Reference
2  [PMID:13475375]
  Authors
STADTMAN TC, ELLIOTT P.
  Title
Studies on the enzymic reduction of amino acids. II. Purification and properties of D-proline reductase and a proline racemase from Clostridium sticklandii.
  Journal
J. Biol. Chem. 228 (1957) 983-97.
Reference
3  [PMID:10085076]
  Authors
Kabisch UC, Grantzdorffer A, Schierhorn A, Rucknagel KP, Andreesen JR, Pich A.
  Title
Identification of D-proline reductase from Clostridium sticklandii as a selenoenzyme and indications for a catalytically active pyruvoyl group derived from a cysteine residue by cleavage of a proprotein.
  Journal
J. Biol. Chem. 274 (1999) 8445-54.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37255-43-9

DBGET integrated database retrieval system