KEGG   ENZYME: 1.21.98.1Help
Entry
EC 1.21.98.1                Enzyme                                 

Name
cyclic dehypoxanthinyl futalosine synthase;
MqnC;
dehypoxanthinyl futalosine cyclase
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
dehypoxanthine futalosine:S-adenosyl-L-methionine oxidoreductase (cyclizing)
Reaction(IUBMB)
dehypoxanthine futalosine + S-adenosyl-L-methionine = cyclic dehypoxanthinyl futalosine + 5'-deoxyadenosine + L-methionine [RN:R08588]
Reaction(KEGG)
Substrate
dehypoxanthine futalosine [CPD:C17010];
S-adenosyl-L-methionine [CPD:C00019]
Product
cyclic dehypoxanthinyl futalosine;
5'-deoxyadenosine [CPD:C05198];
L-methionine [CPD:C00073]
Comment
This enzyme is a member of the 'AdoMet radical' (radical SAM) family. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
History
EC 1.21.98.1 created 2014 as EC 1.21.99.2, transferred 2014 to EC 1.21.98.1
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K11784  cyclic dehypoxanthinyl futalosine synthase
Genes
HPY: HP0656
HEO: C694_03390
HPJ: jhp_0601
HPA: HPAG1_0641
HPS: HPSH_03575
HHP: HPSH112_03730
HHQ: HPSH169_03365
HHR: HPSH417_03175
HPG: HPG27_618
HPP: HPP12_0669
HPL: HPB8_859
HPZ: HPKB_0688
HPD: KHP_0665
HEY: MWE_0852
HPYR: K747_07380
HPYI: K750_05595
HPYU: K751_04100
HPYM: K749_02010
HEB: U063_0960
HEZ: U064_0964
HHE: HH_0991
HAC: Hac_0841
HMS: HMU02880
HCE: HCW_05750
HCM: HCD_05305
HCP: HCN_0131
WSU: WS0351
SUA: Saut_0374
SULR: B649_01390
CJE: Cj0462
CJU: C8J_0435
CJI: CJSA_0432
CJM: CJM1_0444
CJS: CJS3_0454
CJEJ: N564_00444
CJEU: N565_00495
CJEN: N755_00493
CJEI: N135_00510
CJER: H730_02890
CJV: MTVDSCj20_0435(mqnC)
CJY: QZ67_00468(mqnE_1)
CJQ: UC78_0444(mqnE_1)
CJR: CJE0512
CFT: CFF04554_0807(mqnC)
CFV: CFVI03293_0948(mqnC)
CFX: CFV97608_0866(mqnC)
CFZ: CSG_11890
CAMP: CFT03427_0795(mqnC)
CCV: CCV52592_1619(mqnC)
CCO: CCC13826_1528(mqnC)
CCOC: CCON33237_0611(mqnC)
CLA: Cla_0686
CLR: UPTC16701_0697(mqnC)
CLM: UPTC16712_0699(mqnC)
CLQ: UPTC4110_0701(mqnC)
CLN: UPTC3659_0790(mqnC)
CLL: CONCH_0698(mqnC)
CCQ: N149_0459
CCF: YSQ_07555
CCY: YSS_02100
CCOI: YSU_06565
CCOF: VC76_02415(mqnE_1)
CCOO: ATE51_03290(mqnE_2)
CAJ: CIG1485E_1073(mqnC)
CIS: CINS_0666(mqnC)
CVO: CVOL_0680(mqnC)
CPEL: CPEL_0754(mqnC)
CAMR: CAQ16704_1170(mqnC)
CSM: CSUB8521_0733(mqnC)
CSF: CSUB8523_0821(mqnC)
CGRA: CGRAC_1205(mqnC)
CURE: CUREO_1176(mqnC)
CHYO: CHH_0735(mqnC)
CHV: CHELV3228_0571(mqnC)
CSPF: CSF_0533(mqnC)
CPIN: CPIN18020_0716(mqnC)
CCUN: CCUN_0251(mqnC)
CLX: CLAN_0657(mqnC)
ABU: Abu_1212
ABT: ABED_1134
ABL: A7H1H_1210(mqnC)
ARC: ABLL_1539
SDL: Sdel_0850
SMUL: SMUL_1086
SHAL: SHALO_1108
SULJ: SJPD1_1140
NIS: NIS_1358
SUN: SUN_1917
NAM: NAMH_0893
GSU: GSU0442(mqnC-1)
GSK: KN400_0417(mqnC-1)
GME: Gmet_3390(mqnC-1)
GUR: Gura_4285
GLO: Glov_3637
GBM: Gbem_0235(mqnC-1)
GEO: Geob_0417(mqnC-1)
GEM: GM21_0219
GEB: GM18_0264
PCA: Pcar_0320(mqnC-1)
PPD: Ppro_3618
DES: DSOUD_0279(mqnC-1)
DEU: DBW_0514
DVU: DVU2757
DVL: Dvul_0550
DVM: DvMF_1189
DDE: Dde_0797
DDS: Ddes_1280
DMA: DMR_21460
DHY: DESAM_22966(cofH)
DGG: DGI_2623
DEF: CNY67_07305(mqnC)
DAS: Daes_2224
DPI: BN4_20497
PPRF: DPRO_3993(mqnC)
DBA: Dbac_1735
DRT: Dret_1007
DSF: UWK_02736
DOL: Dole_1272
DML: Dmul_31790(cofH2)
DAT: HRM2_33150(fbiC1)
DTO: TOL2_C34510(cofH2)
ADE: Adeh_0371
SFU: Sfum_3088
DBR: Deba_2195
BHA: BH3143
BCL: ABC2699
BKW: BkAM31D_18575(mqnE_1)
BBEV: BBEV_0904
BSE: Bsel_1367
PPY: PPE_01409
PPM: PPSC2_07260(foS2)
PPO: PPM_1378(foS2)
PPOL: X809_07920
PPQ: PPSQR21_015390(thiH)
PPOY: RE92_04630
PMW: B2K_32285
PLV: ERIC2_c35250(cofH1)
PSAB: PSAB_08135
PRI: PRIO_2111
PSWU: SY83_22370
PDH: B9T62_04120(mqnC)
ASOC: CB4_03703(mqnE_2)
BTS: Btus_1755
KYR: CVV65_07740(mqnC)
TAB: CIG75_09655(mqnC)
LFB: C1X05_05020(mqnC)
STH: STH818
SWO: Swol_1159
SLP: Slip_1165
DRM: Dred_2193
DAE: Dtox_1645
PTH: PTH_0207(ThiH)
DAU: Daud_1091
SGY: Sgly_2858
HMO: HM1_1949
CHY: CHY_1804
MTA: Moth_1844
ADG: Adeg_0671
MHG: MHY_27650
PUF: UFO1_1288
PFT: JBW_02990
SCO: SCO4550(SCD16A.33c)
SMA: SAVERM_4825(mqnC)
SGR: SGR_2999
SGB: WQO_20700
SCT: SCAT_3474(cofH)
SFA: Sfla_2633
SBH: SBI_06092
SHY: SHJG_5692
SVE: SVEN_4258
SALB: XNR_3624
STRP: F750_4169
SFI: SFUL_4351
SALU: DC74_3894
SALL: SAZ_20665
STRE: GZL_04992
SLD: T261_4580
STRM: M444_20230
SAMB: SAM23877_4373(mqnC)
SPRI: SPRI_3289
SRW: TUE45_05110(mqnE_3)
SLE: sle_30800(sle_30800)
SRN: A4G23_03246(mqnE_3)
STRD: NI25_16325
SMAL: SMALA_4354
SLAU: SLA_4367
SALJ: SMD11_3755
SLX: SLAV_16455(mqnE1)
KSK: KSE_44990
FAL: FRAAL1025
ACE: Acel_0263
SAQ: Sare_4467
MIL: ML5_0365
AMS: AMIS_2210
ASE: ACPL_441
ACTN: L083_0413
AFS: AFR_01630
PLK: CIK06_01995(mqnC)
CAI: Caci_8059
SNA: Snas_1258
HAU: Haur_4707
XII: AMD24_00288(mqnE_1)
MIN: Minf_1933(thiH)
RBA: RB4160
PSL: Psta_0155
PIR: VN12_12215(mqnE_1)
PLM: Plim_2811
PLS: VT03_29180(mqnE_2)
PLH: VT85_13680(mqnE_1)
TTF: THTE_2522
GES: VT84_38600(mqnE_2)
IPA: Isop_1165
SACI: Sinac_6079
PBOR: BSF38_00883(mqnC)
LIE: LIF_A2213(thiH)
LIS: LIL_11422(thiH)
LST: LSS_01627
ACA: ACP_1642
SUS: Acid_3614
GAU: GAU_1632
GBA: J421_3265
BACC: BRDCF_p917(cofH1)
AFD: Alfi_0418
CPI: Cpin_0701
FLN: FLA_5668
SGN: SGRA_1344
PHE: Phep_1588
PGS: CPT03_02880(mqnC)
MUC: MuYL_3413
MGOT: MgSA37_02114(mqnE_1)
AAE: aq_789
HTH: HTH_1860
TAL: Thal_0893
TTK: TST_1166
CABY: Cabys_3284(mqnC)
CTHI: THC_0242
MOX: DAMO_1578(ThiH)
AFU: AF_0390
FPL: Ferp_1894
GAC: GACE_1761
GAH: GAH_00873
NGA: Ngar_c27060(cofH2)
 » show all
Taxonomy
Reference
1  [PMID:18801996]
  Authors
Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Itoh N, Seto H, Dairi T
  Title
An alternative menaquinone biosynthetic pathway operating in microorganisms.
  Journal
Science. 321 (2008) 1670-3.
  Sequence
[sco:SCO4550]
Reference
2  [PMID:23763543]
  Authors
Cooper LE, Fedoseyenko D, Abdelwahed SH, Kim SH, Dairi T, Begley TP
  Title
In vitro reconstitution of the radical S-adenosylmethionine enzyme MqnC involved  in the biosynthesis of futalosine-derived menaquinone.
  Journal
Biochemistry. 52 (2013) 4592-4.
  Sequence
[bha:BH3143]
Other DBs
ExplorEnz - The Enzyme Database: 1.21.98.1
IUBMB Enzyme Nomenclature: 1.21.98.1
ExPASy - ENZYME nomenclature database: 1.21.98.1
BRENDA, the Enzyme Database: 1.21.98.1

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