KEGG   ENZYME: 1.23.1.4Help
Entry
EC 1.23.1.4                 Enzyme                                 

Name
(-)-lariciresinol reductase;
pinoresinol/lariciresinol reductase;
pinoresinol-lariciresinol reductases;
(-)-pinoresinol-(-)-lariciresinol reductase;
PLR
Class
Oxidoreductases;
Reducing C-O-C group as acceptor;
With NADH or NADPH as donor
BRITE hierarchy
Sysname
(+)-secoisolariciresinol:NADP+ oxidoreductase
Reaction(IUBMB)
(+)-secoisolariciresinol + NADP+ = (-)-lariciresinol + NADPH + H+ [RN:R10228]
Reaction(KEGG)
Substrate
(+)-secoisolariciresinol [CPD:C20456];
NADP+ [CPD:C00006]
Product
(-)-lariciresinol [CPD:C20454];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that also reduces (-)-pinoresinol [EC 1.23.1.3, (-)-pinoresinol reductase]. Isolated from the plants Thuja plicata (western red cedar) [1] and Linum corymbulosum [2].
History
EC 1.23.1.4 created 2013
Orthology
K21568  pinoresinol/lariciresinol reductase
Genes
RSS: 109442576
ATH: AT1G32100(PRR1) AT4G13660(PRR2)
ALY: ARALYDRAFT_473393 ARALYDRAFT_658933
CRB: 17878264 17898640 17899710
CSAT: 104719089 104723827 104723828 104732343 104741806 104757581 104757582 104777243
EUS: EUTSA_v10008239mg EUTSA_v10009995mg EUTSA_v10026944mg
BRP: 103840191 103868905
BNA: 106362498 106441553 106443341 106451749 106451753 106453825 111203922
BOE: 106292815 106294294
THJ: 104798498 104814402 104814409
CPAP: 110826366
LJA: Lj0g3v0024519.1(Lj0g3v0024519.1) Lj0g3v0067389.1(Lj0g3v0067389.1) Lj0g3v0151959.1(Lj0g3v0151959.1) Lj2g3v1536370.1(Lj2g3v1536370.1) Lj6g3v1604000.1(Lj6g3v1604000.1)
JCU: 105632658
BVG: 104893088
SOE: 110801329
DOSA: Os12t0263200-01(Os12g0263200) Os12t0263600-01(Os12g0263600) Os12t0265100-01(Os12g0265100)
BDI: 100842184
ATS: 109737033(LOC109737033) 109785841(LOC109785841) 109785845(LOC109785845) 109785846(LOC109785846)
MUS: 103981518
 » show all
Taxonomy
Reference
1  [PMID:9872995]
  Authors
Fujita M, Gang DR, Davin LB, Lewis NG
  Title
Recombinant pinoresinol-lariciresinol reductases from western red cedar (Thuja plicata) catalyze opposite enantiospecific conversions.
  Journal
J. Biol. Chem. 274 (1999) 618-27.
  Sequence
Reference
2  [PMID:17257599]
  Authors
Hemmati S, Schmidt TJ, Fuss E
  Title
(+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B.
  Journal
FEBS. Lett. 581 (2007) 603-10.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.23.1.4
IUBMB Enzyme Nomenclature: 1.23.1.4
ExPASy - ENZYME nomenclature database: 1.23.1.4
BRENDA, the Enzyme Database: 1.23.1.4

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