KEGG   ENZYME: 1.3.1.101Help
Entry
EC 1.3.1.101                Enzyme                                 

Name
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H];
digeranylgeranylglycerophospholipid reductase;
Ta0516m (gene name);
DGGGPL reductase;
2,3-digeranylgeranylglycerophospholipid reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2,3-bis-(O-phytany)l-sn-glycerol 1-phosphate:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NAD(P)+ = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 NAD(P)H + 8 H+ [RN:R10325 R10326]
Reaction(KEGG)
Substrate
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate [CPD:C20518];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate;
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A flavoprotein (FAD). The enzyme from the archaeon Thermoplasma acidophilum is involved in the biosynthesis of membrane lipids. In vivo the reaction occurs in the reverse direction with the formation of 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate. cf. EC 1.3.7.11, 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase.
History
EC 1.3.1.101 created 2013
Pathway
Glycerophospholipid metabolism
Orthology
K17830  
digeranylgeranylglycerophospholipid reductase
Genes
CMAR: 
TPZ: 
POM: 
IAL: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MBA: 
MBY: 
MBW: 
MBAR: 
MMA: 
MMAZ: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
MEMA: 
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MEZ: 
RCI: 
RCIX2051(bchP)
MTH: 
MMG: 
METC: 
MST: 
MSI: 
MRU: 
MEB: 
MMIL: 
MEYE: 
MEL: 
MEW: 
METH: 
MFC: 
MFI: 
MFV: 
MKA: 
AFU: 
AFG: 
APO: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
HAL: 
HSL: 
HDL: 
HHB: 
HMA: 
HHI: 
HHN: 
HAB: 
NMO: 
HUT: 
HMU: 
HLA: 
HVO: 
HME: 
HFX_1905(fixC)
HGI: 
HTU: 
NMG: 
HXA: 
NAT: 
NPE: 
NGE: 
HRU: 
NOU: 
SALI: 
HLR: 
TAC: 
TVO: 
PTO: 
FAC: 
TAR: 
MAX: 
MER: 
MEAR: 
MARC: 
PHO: 
PH0181(PH0181)
PAB: 
PAB0109(bchP)
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TGA: 
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
TEU: 
TGY: 
THV: 
PPAC: 
ABI: 
ACF: 
VMO: 
TPE: 
THB: 
TCB: 
THF: 
NMR: 
NIR: 
NID: 
NIN: 
NKR: 
CSY: 
NGA: 
NVN: 
NEV: 
TAA: 
CSU: 
NBV: 
TAH: 
KCR: 
LOKI: 
BARC: 
HAH: 
AGW: 
 » show all
Taxonomy
Reference
1  [PMID:16788058]
  Authors
Nishimura Y, Eguchi T
  Title
Biosynthesis of archaeal membrane lipids: digeranylgeranylglycerophospholipid reductase of the thermoacidophilic archaeon Thermoplasma acidophilum.
  Journal
J. Biochem. 139 (2006) 1073-81.
  Sequence
[tac:Ta0516]
Reference
2  [PMID:17275067]
  Authors
Nishimura Y, Eguchi T
  Title
Stereochemistry of reduction in digeranylgeranylglycerophospholipid reductase involved in the biosynthesis of archaeal membrane lipids from Thermoplasma acidophilum.
  Journal
Bioorg. Chem. 35 (2007) 276-83.
  Sequence
[tac:Ta0516]
Reference
3  [PMID:20869368]
  Authors
Xu Q, Eguchi T, Mathews II, Rife CL, Chiu HJ, Farr CL, Feuerhelm J, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Weekes D, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA
  Title
Insights into substrate specificity of geranylgeranyl reductases revealed by the  structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids.
  Journal
J. Mol. Biol. 404 (2010) 403-17.
  Sequence
[tac:Ta0516]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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