KEGG   ENZYME: 1.3.1.101Help
Entry
EC 1.3.1.101                Enzyme                                 

Name
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H];
digeranylgeranylglycerophospholipid reductase;
Ta0516m (gene name);
DGGGPL reductase;
2,3-digeranylgeranylglycerophospholipid reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2,3-bis-(O-phytany)l-sn-glycerol 1-phosphate:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NAD(P)+ = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 NAD(P)H + 8 H+ [RN:R10325 R10326]
Reaction(KEGG)
Substrate
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate [CPD:C20518];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate;
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A flavoprotein (FAD). The enzyme from the archaeon Thermoplasma acidophilum is involved in the biosynthesis of membrane lipids. In vivo the reaction occurs in the reverse direction with the formation of 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate. cf. EC 1.3.7.11, 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase.
History
EC 1.3.1.101 created 2013
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K17830  digeranylgeranylglycerophospholipid reductase
Genes
CMAR: IMCC12053_1371
TPZ: Tph_c09910(bchP)
POM: MED152_04120
POB: LPB03_16045
PRN: BW723_10930
IAL: IALB_0329
CABY: Cabys_957
MJA: MJ_0532
MFE: Mefer_0023
MVU: Metvu_0470
MMP: MMP0388
MMD: GYY_02010
MAE: Maeo_1307
MVO: Mvol_1689
MAC: MA_1484
MMA: MM_2499
MMH: Mmah_1613
MPY: Mpsy_2554
MTP: Mthe_0044
MHU: Mhun_1123
MLA: Mlab_0431
MEMA: MMAB1_2023
MPI: Mpet_1752
MBN: Mboo_1945
MPL: Mpal_0962
MEZ: Mtc_0895(bchP) Mtc_1724
RCI: RCIX2051(bchP)
METE: tca_00257(menJ_1) tca_01663(menJ_2)
MSI: Msm_1701
MRU: mru_1471
MMIL: sm9_1381
MEYE: TL18_04135
MFV: Mfer_1222
AFU: AF_0464
FPL: Ferp_0366
GAC: GACE_0072
GAH: GAH_00300
HAL: VNG_0468C
HSL: OE_1699R
HHB: Hhub_1531
HMA: rrnAC0726
HHI: HAH_1373
HUT: Huta_1007
HMU: Hmuk_3091
HVO: HVO_1799
HME: HFX_1905(fixC)
HLA: Hlac_0926
HTU: Htur_3081
NMG: Nmag_2507
NAT: NJ7G_2427
SALI: L593_01650
TAC: Ta0516
TVO: TVG1046096(TVG1046096)
PTO: PTO0896
FAI: FAD_1079
CDIV: CPM_0894
MARC: AR505_1433
PHO: PH0181(PH0181)
PAB: PAB0109(bchP)
PFU: PF0097
PFI: PFC_07720
PYN: PNA2_0702
PYS: Py04_0252
TKO: TK1088
TON: TON_0316
TGA: TGAM_1305
TSI: TSIB_0988
THE: GQS_03690
THA: TAM4_1982
THM: CL1_0388
TLT: OCC_08470
THS: TES1_0613
TNU: BD01_0182
TEU: TEU_06540
PPAC: PAP_07210
ABI: Aboo_0578
VDI: Vdis_1715
VMO: VMUT_2242
TPE: Tpen_0718
NMR: Nmar_0631
NCT: NMSP_1055
NEV: NTE_02579
NBV: T478_0975
NDV: NDEV_0107
BARC: AOA65_0632
 » show all
Taxonomy
Reference
1  [PMID:16788058]
  Authors
Nishimura Y, Eguchi T
  Title
Biosynthesis of archaeal membrane lipids: digeranylgeranylglycerophospholipid reductase of the thermoacidophilic archaeon Thermoplasma acidophilum.
  Journal
J. Biochem. 139 (2006) 1073-81.
  Sequence
[tac:Ta0516]
Reference
2  [PMID:17275067]
  Authors
Nishimura Y, Eguchi T
  Title
Stereochemistry of reduction in digeranylgeranylglycerophospholipid reductase involved in the biosynthesis of archaeal membrane lipids from Thermoplasma acidophilum.
  Journal
Bioorg. Chem. 35 (2007) 276-83.
  Sequence
[tac:Ta0516]
Reference
3  [PMID:20869368]
  Authors
Xu Q, Eguchi T, Mathews II, Rife CL, Chiu HJ, Farr CL, Feuerhelm J, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Weekes D, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA
  Title
Insights into substrate specificity of geranylgeranyl reductases revealed by the  structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids.
  Journal
J. Mol. Biol. 404 (2010) 403-17.
  Sequence
[tac:Ta0516]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.101
IUBMB Enzyme Nomenclature: 1.3.1.101
ExPASy - ENZYME nomenclature database: 1.3.1.101
BRENDA, the Enzyme Database: 1.3.1.101

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