KEGG   ENZYME: 1.3.1.102Help
Entry
EC 1.3.1.102                Enzyme                                 

Name
2-alkenal reductase (NADP+);
NADPH-dependent alkenal/one oxidoreductase;
NADPH:2-alkenal alpha,beta-hydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
n-alkanal:NADP+ 2-oxidoreductase
Reaction(IUBMB)
an n-alkanal + NADP+ = an alk-2-enal + NADPH + H+ [RN:R07350]
Reaction(KEGG)
Substrate
n-alkanal [CPD:C15596];
NADP+ [CPD:C00006]
Product
alk-2-enal [CPD:C15597];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Shows highest activity with 1-nitrocyclohexene but also has significant activity with 2-methylpentenal and trans-cinnamaldehyde [3]. Involved in the detoxication of alpha,beta-unsaturated aldehydes and ketones. Has very low activity with NAD as reductant (cf. EC 1.3.1.74, 2-alkenal reductase [NAD(P)+]).
History
EC 1.3.1.102 created 2013
Orthology
K19825  
2-alkenal reductase (NADP+)
Genes
SLY: 
SOT: 
Taxonomy
Reference
1  [PMID:11117876]
  Authors
Hirata T, Tamura Y, Yokobatake N, Shimoda K, Ashida Y
  Title
A 38 kDa allylic alcohol dehydrogenase from the cultured cells of Nicotiana tabacum.
  Journal
Phytochemistry. 55 (2000) 297-303.
  Sequence
Reference
2  [PMID:17945329]
  Authors
Matsushima A, Sato Y, Otsuka M, Watanabe T, Yamamoto H, Hirata T
  Title
An enone reductase from Nicotiana tabacum: cDNA cloning, expression in Escherichia coli, and reduction of enones with the recombinant proteins.
  Journal
Bioorg. Chem. 36 (2008) 23-8.
  Sequence
Reference
3
  Authors
Mansell, D.J., Toogood, H.S., Waller, J., Hughes, J.M.X., Levy, C.W., Gardiner, J.M., and Scrutton, N.S.
  Title
Biocatalytic asymmetric alkene reduction: crystal structure and characterization of a double bond reductase from Nicotiana tabacum.
  Journal
ACS Catal. 3 (2013) 370-379.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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