KEGG   ENZYME: 1.3.1.104Help
Entry
EC 1.3.1.104                Enzyme                                 

Name
enoyl-[acyl-carrier-protein] reductase (NADPH);
acyl-ACP dehydrogenase (ambiguous);
enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase;
NADPH 2-enoyl Co A reductase;
enoyl-ACP reductase (ambiguous);
fabL (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
acyl-[acyl-carrier protein]:NADP+ oxidoreductase
Reaction(IUBMB)
an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ [RN:R01404]
Reaction(KEGG)
Substrate
acyl-[acyl-carrier protein] [CPD:C00173];
NADP+ [CPD:C00006]
Product
trans-2,3-dehydroacyl-[acyl-carrier protein] [CPD:C00693];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl-carrier protein, in an NADPH-dependent manner. This entry stands for enzymes whose stereo-specificity with respect to NADP+ is not known. [cf. EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific), EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.3.1.9, enoyl-[acyl-carrier-protein] reductase (NADH)].
History
EC 1.3.1.104 created 2013
Pathway
ec00061  Fatty acid biosynthesis
ec01100  Metabolic pathways
Orthology
K10780  enoyl-[acyl-carrier protein] reductase III
Genes
SMAF: D781_2232
SFW: WN53_21285
SFG: AV650_17030
SRZ: AXX16_2910
PALC: A0T30_17150
LPH: LPV_0452
LPO: LPO_0408
LPU: LPE509_02876
LPM: LP6_0350(fabL)
LPA: lpa_00572
LPE: lp12_0359
LLO: LLO_0519
LFA: LFA_2780(fabL)
LHA: LHA_0370(fabL)
LOK: Loa_00420
LCD: clem_13305(fabL)
TMC: LMI_0465(fabL)
BSU: BSU08650(fabL)
BSR: I33_0968
BSL: A7A1_0300
BSH: BSU6051_08650(fabL)
BSUT: BSUB_00939(fabL)
BSUL: BSUA_00939(fabL)
BSUS: Q433_04825
BSS: BSUW23_04355(fabL)
BST: GYO_1133
BSO: BSNT_07250(fabL)
BSQ: B657_08650(fabL)
BSX: C663_0887(fabL)
BLI: BL03039(fabL)
BLD: BLi00887(fabL)
BLH: BaLi_c09910(fabL)
BAY: RBAM_008740(fabL)
BAQ: BACAU_0849(fabL)
BYA: BANAU_0792(fabL)
BAMP: B938_04215
BAML: BAM5036_0783(fabL)
BAMA: RBAU_0847(fabL)
BAMN: BASU_0823(fabL)
BAMB: BAPNAU_0805(fabL)
BAMT: AJ82_04870
BAMY: V529_08190(fabL)
BMP: NG74_00869(fabL)
BAO: BAMF_0873(fabL)
BAZ: BAMTA208_03980(fabL)
BQL: LL3_00935(fabL)
BXH: BAXH7_00830(fabL)
BQY: MUS_0887(fabL)
BAMI: KSO_015445
BAMC: U471_08640
BAMF: U722_04360
BATR: TD68_01455
BHA: BH0938
BCL: ABC1313(fabL)
BPU: BPUM_0812
BPUM: BW16_04360
BPUS: UP12_04370
BMQ: BMQ_0404
BMD: BMD_0405
BMH: BMWSH_4822(fabL)
BMEG: BG04_2695(fabL)
BAG: Bcoa_2111
BCOA: BF29_1474(fabL)
BJS: MY9_0954
BMET: BMMGA3_03445(fabL)
BACW: QR42_04160
BACP: SB24_05545
BACB: OY17_07015
BACY: QF06_03160
BACL: BS34A_09630(fabL)
BALM: BsLM_0900
BEO: BEH_02810
BGY: BGLY_0909(fabL)
GKA: GK0465
GTN: GTNG_0470(fabI)
GGH: GHH_c04870(fabL)
GEA: GARCT_00511(fabL)
ANM: GFC28_2058(fabL)
AAMY: GFC30_882(fabL)
ANL: GFC29_3376(fabL)
LMO: lmo1688
LMS: LMLG_1553
LMQ: LMM7_1777(fabL)
LML: lmo4a_1745(fabL)
LMP: MUO_08685
LMW: LMOSLCC2755_1700(fabL)
LMX: LMOSLCC2372_1754(fabL)
LMZ: LMOSLCC2482_1752(fabL)
LMON: LMOSLCC2376_1647(fabL)
LMOC: LMOSLCC5850_1751(fabL)
LMOS: LMOSLCC7179_1662(fabL)
LMOO: LMOSLCC2378_1709(fabL)
LMOY: LMOSLCC2479_1752(fabL)
LMOT: LMOSLCC2540_1771(fabL)
LMOA: LMOATCC19117_1703(fabL)
LMOL: LMOL312_1695(fabL)
LMOG: BN389_17160(fabL)
LMOE: BN418_2021
LMOB: BN419_2025
LMOD: LMON_1755
LMOW: AX10_02655
LMOX: AX24_06135
LMOQ: LM6179_2444(fabL)
LMR: LMR479A_1790(fabL)
LMOK: CQ02_08775
LMOM: IJ09_01415
LIN: lin1796
LWE: lwe1706
LSG: lse_1656
LIV: LIV_1663
BBE: BBR47_10320(fabL)
BLR: BRLA_c007290(fabL)
ASOC: CB4_03899(fabL_1)
AAC: Aaci_2412
AAD: TC41_2687(fabG) TC41_2700(fabL)
BTS: Btus_2604
JEO: JMA_12600
SAY: TPY_3240(fabL)
LPIL: LIP_1119
SFA: Sfla_5328
STRP: F750_1295
SLE: sle_01250(sle_01250)
NDK: I601_1166(fabL)
PDX: Psed_2586
KAL: KALB_7822
AFO: Afer_1057
ATM: ANT_17280
TTR: Tter_0966
RBA: RB10454(chcA)
PLM: Plim_1674
 » show all
Taxonomy
Reference
1  [PMID:11007778]
  Authors
Heath RJ, Su N, Murphy CK, Rock CO
  Title
The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis.
  Journal
J. Biol. Chem. 275 (2000) 40128-33.
  Sequence
[bsu:BSU08650]
Reference
2  [PMID:17329825]
  Authors
Kim KH, Park JK, Ha BH, Moon JH, Kim EE
  Title
Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis.
  Journal
Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 63 (2007) 246-8.
Reference
3  [PMID:21185310]
  Authors
Kim KH, Ha BH, Kim SJ, Hong SK, Hwang KY, Kim EE
  Title
Crystal structures of Enoyl-ACP reductases I (FabI) and III (FabL) from B. subtilis.
  Journal
J. Mol. Biol. 406 (2011) 403-15.
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.104
IUBMB Enzyme Nomenclature: 1.3.1.104
ExPASy - ENZYME nomenclature database: 1.3.1.104
BRENDA, the Enzyme Database: 1.3.1.104

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