KEGG   ENZYME: 1.3.1.105Help
Entry
EC 1.3.1.105                Enzyme                                 

Name
2-methylene-furan-3-one reductase;
FaEO;
SIEO;
enone oxidoreductase;
4-hydroxy-2,5-dimethylfuran-3(2H)-one:NAD(P)+ oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-hydroxy-2,5-dimethylfuran-3(2H)-one:NADP+ oxidoreductase
Reaction(IUBMB)
4-hydroxy-2,5-dimethylfuran-3(2H)-one + NADP+ = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + NADPH + H+ [RN:R10593]
Reaction(KEGG)
Substrate
4-hydroxy-2,5-dimethylfuran-3(2H)-one [CPD:C20717];
NADP+ [CPD:C00006]
Product
4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one [CPD:C20718];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme was dicovered in strawberry (Fragaria x ananassa), where it produces furaneol, one of the major aroma compounds in the fruits. It has also been detected in tomato (Solanum lycopersicum) and pineapple (Ananas comosus). The enzyme can also act on derivatives substituted at the methylene functional group. The enzyme from the yeast Saccharomyces cerevisiae acts on (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one and produces homofuraneol, an important aroma compound in soy sauce and miso. NADPH is the preferred cofactor.
History
EC 1.3.1.105 created 2013
Orthology
K18980  
2-methylene-furan-3-one reductase
Genes
ATH: 
ALY: 
CRB: 
CSAT: 
EUS: 
BRP: 
BNA: 
BOE: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
GHI: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0339299.1(Lj0g3v0339299.1) Lj1g3v3641800.1(Lj1g3v3641800.1) Lj1g3v3641820.1(Lj1g3v3641820.1) Lj1g3v3641840.1(Lj1g3v3641840.1) Lj2g3v1014110.1(Lj2g3v1014110.1) Lj3g3v2722620.1(Lj3g3v2722620.1) Lj5g3v0642790.1(Lj5g3v0642790.1) Lj5g3v0642800.1(Lj5g3v0642800.1)
LANG: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
ZJU: 
CSV: 
101210358(CsCytAOR) 101215501(CsChlAOR)
CMO: 
MCHA: 
RCU: 
JCU: 
POP: 
VVI: 
SLY: 
SPEN: 
SOT: 
CANN: 
NTA: 
NSY: 
NTO: 
INI: 
SIND: 
HAN: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os08t0379400-01(Os08g0379400)
OBR: 
BDI: 
ATS: 
SBI: 
ZMA: 
SITA: 
PDA: 
EGU: 
MUS: 
DCT: 
ATR: 
SMO: 
PPP: 
CCP: 
CCI: 
SMIN: 
v1.2.022707.t1(symbB.v1.2.022707.t1)
FCY: 
PIF: 
PSOJ: 
 » show all
Taxonomy
Reference
1  [PMID:16517758]
  Authors
Raab T, Lopez-Raez JA, Klein D, Caballero JL, Moyano E, Schwab W, Munoz-Blanco J
  Title
FaQR, required for the biosynthesis of the strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone, encodes an enone oxidoreductase.
  Journal
Plant. Cell. 18 (2006) 1023-37.
  Sequence
[fve:101294385]
Reference
2  [PMID:17636940]
  Authors
Klein D, Fink B, Arold B, Eisenreich W, Schwab W
  Title
Functional characterization of enone oxidoreductases from strawberry and tomato fruit.
  Journal
J. Agric. Food. Chem. 55 (2007) 6705-11.
Reference
3  [PMID:23589283]
  Authors
Schiefner A, Sinz Q, Neumaier I, Schwab W, Skerra A
  Title
Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone.
  Journal
J. Biol. Chem. 288 (2013) 16815-26.
Reference
4  [PMID:27865643]
  Authors
Uehara K, Watanabe J, Mogi Y, Tsukioka Y
  Title
Identification and characterization of an enzyme involved in the biosynthesis of  the 4-hydroxy-2(or 5)-ethyl-5(or 2)-methyl-3(2H)-furanone in yeast.
  Journal
J. Biosci. Bioeng. 123 (2017) 333-341.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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