KEGG   ENZYME: 1.3.1.105Help
Entry
EC 1.3.1.105                Enzyme                                 

Name
2-methylene-furan-3-one reductase;
FaEO;
SIEO;
enone oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-hydroxy-2,5-dimethylfuran-3(2H)-one:NAD(P)+ oxidoreductase
Reaction(IUBMB)
4-hydroxy-2,5-dimethylfuran-3(2H)-one + NAD(P)+ = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + NAD(P)H + H+ [RN:R10592 R10593]
Reaction(KEGG)
Substrate
4-hydroxy-2,5-dimethylfuran-3(2H)-one [CPD:C20717];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one [CPD:C20718];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
In the fruit-ripening process of strawberry (Fragaria x ananassa) the reaction is catalysed in the reverse direction from that shown. 4-hydroxy-2,5-dimethylfuran-3(2H)-one is one of the major aroma compounds in the fruits. The enzyme has also been detected in tomato (Solanum lycopersicum) fruits [2]. NADPH is the preferred cofactor.
History
EC 1.3.1.105 created 2013
Orthology
K18980  
2-methylene-furan-3-one reductase
Genes
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0339299.1(Lj0g3v0339299.1) Lj1g3v3641800.1(Lj1g3v3641800.1) Lj1g3v3641820.1(Lj1g3v3641820.1) Lj1g3v3641840.1(Lj1g3v3641840.1) Lj1g3v3641870.1(Lj1g3v3641870.1) Lj2g3v1014110.1(Lj2g3v1014110.1) Lj3g3v2722620.1(Lj3g3v2722620.1) Lj5g3v0642790.1(Lj5g3v0642790.1) Lj5g3v0642800.1(Lj5g3v0642800.1) Lj5g3v0642830.1(Lj5g3v0642830.1)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
101210358(CsCytAOR) 101215501(CsChlAOR)
CMO: 
RCU: 
JCU: 
POP: 
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os08t0379400-01(Os08g0379400)
OBR: 
BDI: 
ATS: 
ZMA: 
100284837(GRMZM2G127361)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CCP: 
CCI: 
SMIN: 
v1.2.022707.t1(symbB.v1.2.022707.t1)
PIF: 
PSOJ: 
 » show all
Taxonomy
Reference
1  [PMID:16517758]
  Authors
Raab T, Lopez-Raez JA, Klein D, Caballero JL, Moyano E, Schwab W, Munoz-Blanco J
  Title
FaQR, required for the biosynthesis of the strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone, encodes an enone oxidoreductase.
  Journal
Plant. Cell. 18 (2006) 1023-37.
  Sequence
[fve:101294385]
Reference
2  [PMID:17636940]
  Authors
Klein D, Fink B, Arold B, Eisenreich W, Schwab W
  Title
Functional characterization of enone oxidoreductases from strawberry and tomato fruit.
  Journal
J. Agric. Food. Chem. 55 (2007) 6705-11.
Reference
3  [PMID:23589283]
  Authors
Schiefner A, Sinz Q, Neumaier I, Schwab W, Skerra A
  Title
Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone.
  Journal
J. Biol. Chem. 288 (2013) 16815-26.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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