KEGG   ENZYME: 1.3.1.15Help
Entry
EC 1.3.1.15                 Enzyme                                 

Name
dihydroorotate dehydrogenase (NADP+);
orotate reductase;
dihydro-orotic dehydrogenase;
L-5,6-dihydro-orotate:NAD+ oxidoreductase;
orotate reductase (NADPH)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(S)-dihydroorotate:NADP+ oxidoreductase
Reaction(IUBMB)
(S)-dihydroorotate + NADP+ = orotate + NADPH + H+ [RN:R01866]
Reaction(KEGG)
Substrate
(S)-dihydroorotate [CPD:C00337];
NADP+ [CPD:C00006]
Product
orotate [CPD:C00295];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Binds FMN and FAD [2]. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NAD+ (EC 1.3.1.14) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor .
History
EC 1.3.1.15 created 1972, modified 2011
Reference
1  [PMID:4380263]
  Authors
Taylor WH, Taylor ML, Eames DF.
  Title
Two functionally different dihydroorotic dehydrogenases in bacteria.
  Journal
J. Bacteriol. 91 (1966) 2251-6.
Reference
2  [PMID:13923427]
  Authors
UDAKA S, VENNESLAND B
  Title
Properties of triphosphopyridine nucleotide-linked dihydroorotic dehydrogenase.
  Journal
J. Biol. Chem. 237 (1962) 2018-24.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37255-27-9

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