KEGG   ENZYME: 1.3.1.2Help
Entry
EC 1.3.1.2                  Enzyme                                 
Name
dihydropyrimidine dehydrogenase (NADP+);
dihydrothymine dehydrogenase;
dihydrouracil dehydrogenase (NADP+);
4,5-dihydrothymine: oxidoreductase;
DPD;
DHPDH;
dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate);
DHU dehydrogenase;
hydropyrimidine dehydrogenase;
dihydropyrimidine dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
5,6-dihydrouracil:NADP+ 5-oxidoreductase
Reaction(IUBMB)
5,6-dihydrouracil + NADP+ = uracil + NADPH + H+ [RN:R00978]
Reaction(KEGG)
R00978;
(other) R01415 R08226
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Substrate
5,6-dihydrouracil [CPD:C00429];
NADP+ [CPD:C00006]
Product
uracil [CPD:C00106];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on dihydrothymine.
Pathway
Pyrimidine metabolism
beta-Alanine metabolism
Pantothenate and CoA biosynthesis
Drug metabolism - other enzymes
Metabolic pathways
Orthology
K00207  
dihydropyrimidine dehydrogenase (NADP+)
Genes
HSA: 
1806(DPYD)
PTR: 
457047(DPYD)
PPS: 
100967375(DPYD)
GGO: 
PON: 
100173131(DPYD)
MCC: 
715672(DPYD)
MMU: 
99586(Dpyd)
RNO: 
81656(Dpyd)
CFA: 
479935(DPYD)
AML: 
100466550(DPYD)
FCA: 
101084380(DPYD)
BTA: 
281124(DPYD)
SSC: 
397109(DPYD)
ECB: 
100057177(DPYD)
MDO: 
100032923(DPYD)
SHR: 
100930277(DPYD)
OAA: 
100077139
GGA: 
429083(DPYD)
MGP: 
100538897
TGU: 
100222559(DPYD)
ACS: 
100566998(dpyd)
XLA: 
447312(dpyd)
XTR: 
734021(dpyd)
DRE: 
405829(dpydb)
TRU: 
101067586
OLA: 
101175598
BFO: 
BRAFLDRAFT_129513
CIN: 
100175681(dpyd)
SPU: 
575768 757039
DME: 
Dmel_CG2194(su(r))
DPO: 
Dpse_GA15293
DAN: 
Dana_GF19101
DER: 
Dere_GG18994
DSE: 
Dsec_GM13670
DSI: 
Dsim_GD16077
DWI: 
Dwil_GK25544
DYA: 
Dyak_GE17405
DGR: 
Dgri_GH17755
DMO: 
Dmoj_GI15089
DVI: 
Dvir_GJ18897
AGA: 
AgaP_AGAP001021
AAG: 
AaeL_AAEL010204 AaeL_AAEL014199
CQU: 
CpipJ_CPIJ005573
AME: 
410207
NVI: 
100121034(NV11418)
TCA: 
658821
API: 
100163680
PHU: 
Phum_PHUM424200
ISC: 
IscW_ISCW022746
CEL: 
CELE_C25F6.3(dpyd-1)
CBR: 
CBG14689(Cbr-dpyd-1)
NVE: 
NEMVE_v1g190441
AQU: 
100641502(Dpyd)
ATH: 
AT3G17810(PYD1)
ALY: 
ARALYDRAFT_479265
GMX: 
100818990
MTR: 
MTR_6g071210
CSV: 
101202899 101229259
RCU: 
RCOM_0084140
POP: 
POPTR_1114490
VVI: 
100249021
OSA: 
4330657
DOSA: 
Os02t0736400-01(Os02g0736400)
BDI: 
100844077
SBI: 
SORBI_04g028610(SORBIDRAFT_04g028610)
ZMA: 
100274265(cl32009_1b)
SMO: 
SELMODRAFT_80950 SELMODRAFT_88846
PPP: 
PHYPADRAFT_73095
CRE: 
CHLREDRAFT_134846(TBA1)
VCN: 
VOLCADRAFT_80405
NGR: 
NAEGRDRAFT_78714
DDI: 
DDB_G0267966(pyd1)
EHI: 
EHI_012980(14.t00017)
EDI: 
EDI_044620
TET: 
TTHERM_01250100
PTM: 
GSPATT00007208001
TVA: 
TVAG_151830 TVAG_338230
PAE: 
PA0439
PAU: 
PA14_05740(pydA)
PPU: 
PP_4038
PFL: 
PFL_2546
PFO: 
Pfl01_3443
BXE: 
Bxe_A1429
PNA: 
Pnap_4020
AAV: 
Aave_0967
VEI: 
Veis_4151
MLO: 
mll1643
MES: 
Meso_2055
SME: 
SMc01815
BMF: 
BAB1_0313
BMS: 
BR0282
BBT: 
BBta_6035
SIL: 
SPO1777
SIT: 
TM1040_1500
RSQ: 
Rsph17025_1458
SUS: 
Acid_7660
HMA: 
rrnAC0052(dpd)
 » show all
Taxonomy
Reference
1  [PMID:13825299]
  Authors
FRITZSON P.
  Title
Properties and assay of dihydrouracil dehydrogenase of rat liver.
  Journal
J. Biol. Chem. 235 (1960) 719-25.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:7451435]
  Authors
Shiotani T, Weber G.
  Title
Purification and properties of dihydrothymine dehydrogenase from rat liver.
  Journal
J. Biol. Chem. 256 (1981) 219-24.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-01-0
DBGET integrated database retrieval system