KEGG   ENZYME: 1.3.1.36Help
Entry
EC 1.3.1.36                 Enzyme                                 

Name
geissoschizine dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
geissoschizine:NADP+ 4,21-oxidoreductase
Reaction(IUBMB)
geissoschizine + NADP+ = 4,21-didehydrogeissoschizine + NADPH [RN:R03860]
Reaction(KEGG)
Substrate
geissoschizine [CPD:C02151];
NADP+ [CPD:C00006]
Product
4,21-didehydrogeissoschizine;
NADPH [CPD:C00005]
Comment
Involved in the interconversion of heteroyohimbine alkaloids in Catharanthus roseus.
History
EC 1.3.1.36 created 1986
Pathway
Indole alkaloid biosynthesis
Biosynthesis of secondary metabolites
Reference
1
  Authors
Pfitzner, A. and Stockigt, J.
  Title
Partial-purification and characterization of geissoschizine dehydrogenase from suspension-cultures of Catharanthus roseus.
  Journal
Phytochemistry 21 (1982) 1585-1588.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
84399-94-0

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