KEGG ENZYME: 1.3.1.38

ENZYME: 1.3.1.38

Entry

EC 1.3.1.38 Enzyme

Name

trans-2-enoyl-CoA reductase (NADPH);
NADPH-dependent trans-2-enoyl-CoA reductase;
reductase, trans-enoyl coenzyme A;
trans-2-enoyl-CoA reductase (NADPH2)

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

acyl-CoA:NADP+ trans-2-oxidoreductase

Reaction(IUBMB)

acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+ [RN:R07162]

Reaction(KEGG)

R07162 > R01278 R03776 R03856 R03989 R04753 R06985 R07761

Substrate

acyl-CoA [CPD:C00040];
NADP+ [CPD:C00006]

Product

trans-2,3-dehydroacyl-CoA [CPD:C00658];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Not identical with EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) [cf. EC 1.3.1.8 acyl-CoA dehydrogenase (NADP+)].

Pathway

ec00062	Fatty acid elongation
ec01040	Biosynthesis of unsaturated fatty acids
ec01100	Metabolic pathways

Orthology

K07512	mitochondrial trans-2-enoyl-CoA reductase
K07753	peroxisomal trans-2-enoyl-CoA reductase

Genes

HSA:	51102(MECR) 55825(PECR)
PTR:	456690(MECR) 459929(PECR)
PPS:	100978479(PECR) 100993891(MECR)
GGO:	101131268(MECR) 101141591(PECR)
PON:	100174357(PECR) 100457156(MECR)
MCC:	695174(PECR) 717425(MECR)
MMU:	111175(Pecr) 26922(Mecr)
RNO:	113956(Pecr) 29470(Mecr)
CFA:	478159(MECR) 478901(PECR)
AML:	100463885 100475522
FCA:	101083284(PECR) 101092129(MECR)
BTA:	353301(MECR) 617037(PECR)
SSC:	100312978(PECR) 100515782(MECR)
ECB:	100054894 100070598(MECR)
MDO:	100013660 100021687
SHR:	100917241(MECR) 100921608
OAA:	100084885 100086606 100087829
GGA:	419601(MECR) 424224(PECR)
MGP:	100543674 100550872
TGU:	100230450(MECR) 100232325(PECR)
ACS:	100557192 100559419
XLA:	446674(pecr)
XTR:	496922(pecr) 549125(mecr)
DRE:	550422(pecr) 550550(mecr)
TRU:	101075341 101078949
OLA:	101160843 101166333
BFO:	BRAFLDRAFT_213557 BRAFLDRAFT_241416 BRAFLDRAFT_59435
CIN:	100175355
SPU:	574708 753057
DME:	Dmel_CG16935
DPO:	Dpse_GA24989
DAN:	Dana_GF11158
DER:	Dere_GG22463
DPE:	Dper_GL16992
DSE:	Dsec_GM20249
DSI:	Dsim_GD25735
DWI:	Dwil_GK21344
DYA:	Dyak_GE13334
DGR:	Dgri_GH20863
DMO:	Dmoj_GI20971
DVI:	Dvir_GJ20691
AGA:	AgaP_AGAP011834
AAG:	AaeL_AAEL003995
CQU:	CpipJ_CPIJ006453
AME:	411662
NVI:	100119843(NV12929)
TCA:	663279
API:	100159788
PHU:	Phum_PHUM127430
ISC:	IscW_ISCW002637 IscW_ISCW004170 IscW_ISCW021769
CEL:	CELE_W09H1.5(mecr-1) CELE_Y48A6B.9(Y48A6B.9)
CBR:	CBG02814 CBG18225
BMY:	Bm1_31850
TSP:	Tsp_03549 Tsp_07030
SMM:	Smp_026310
NVE:	NEMVE_v1g100670 NEMVE_v1g228294
HMG:	100213067
AQU:	100632199 100632804
ATH:	AT3G45770
ALY:	ARALYDRAFT_484959
GMX:	100810089
MTR:	MTR_2g095840
CSV:	101215312
RCU:	RCOM_0327490
POP:	POPTR_1116878
VVI:	100257075
OSA:	4351241
DOSA:	Os12t0102100-01(Os12g0102100)
BDI:	100829535 100833024 100843602
SBI:	SORBI_07g006220(SORBIDRAFT_07g006220)
ZMA:	100501714
SMO:	SELMODRAFT_74091 SELMODRAFT_92070
PPP:	PHYPADRAFT_118360
CRE:	CHLREDRAFT_101411
OLU:	OSTLU_45262
OTA:	Ot03g01300
SCE:	YBR026C(ETR1)
AGO:	AGOS_AEL081W
ERC:	Ecym_3544
KLA:	KLLA0F24552g
LTH:	KLTH0C09020g
PPA:	PAS_chr4_0311
VPO:	Kpol_1036p36
ZRO:	ZYRO0A03916g
CGR:	CAGL0B04323g
NCS:	NCAS_0A10280(NCAS0A10280)
NDI:	NDAI_0A07200(NDAI0A07200)
TPF:	TPHA_0M00590(TPHA0M00590)
TBL:	TBLA_0G02880(TBLA0G02880)
TDL:	TDEL_0D03960(TDEL0D03960)
KAF:	KAFR_0F02350(KAFR0F02350)
DHA:	DEHA2C05808g
PIC:	PICST_34892(ETR2)
PGU:	PGUG_05322
LEL:	LELG_02281
CAL:	CaO19.12905(ETR1) CaO19.5450(ETR1)
CTP:	CTRG_06166
CDU:	CD36_80180
COT:	CORT_0D07560
YLI:	YALI0C19624g
CLU:	CLUG_00888
NCR:	NCU00655
SMP:	SMAC_01336
PAN:	PODANSg4501
TTT:	THITE_2111907
MTM:	MYCTH_39983
MGR:	MGG_02566
FGR:	FG08521.1
NHE:	NECHADRAFT_99584
SSL:	SS1G_11336
BFU:	BC1G_08787
ANI:	AN9401.2
NFI:	NFIA_006420
AFM:	AFUA_3G04150
AOR:	AOR_1_146104(AO090124000077)
AFV:	AFLA_089230
ACT:	ACLA_060640
PCS:	Pc14g00670
CIM:	CIMG_08466
CPW:	CPC735_061360
PBL:	PAAG_01536
URE:	UREG_02545
ABE:	ARB_06054
TVE:	TRV_08128
AJE:	HCAG_07622
PNO:	SNOG_02540
PTE:	PTT_19942
ZTR:	MYCGRDRAFT_84372
TML:	GSTUM_00004457001
SPO:	SPAC26F1.04c(etr1)
LBC:	LACBIDRAFT_229832
MPR:	MPER_02853
CCI:	CC1G_14862
SCM:	SCHCODRAFT_68008
PGR:	PGTG_02130
MBR:	MONBRDRAFT_1704
NGR:	NAEGRDRAFT_58740
DDI:	DDB_G0278095(mecr)
DPP:	DICPUDRAFT_50320
PTI:	PHATRDRAFT_37372 PHATR_10497
TPS:	THAPSDRAFT_262229(ECR1)
PIF:	PITG_02274 PITG_15045

» show all

Reference

1 [PMID:6759504]

Authors

Mizugaki M, Nishimaki T, Shiraishi T, Kawaguchi A, Okuda S, Yamanaka H.

Title

Studies on the metabolism of unsaturated fatty acids. IX. Stereochemical studies of the reaction catalyzed by trans-2-enoyl-coenzyme A reductase of Escherichia coli.

Journal

J. Biochem. (Tokyo). 92 (1982) 1649-54.

Organism

Escherichia coli [GN:eco]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.1.38

IUBMB Enzyme Nomenclature:

1.3.1.38

ExPASy - ENZYME nomenclature database:

1.3.1.38

BRENDA, the Enzyme Database:

1.3.1.38

CAS:

77649-64-0

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