KEGG   ENZYME: 1.3.1.40Help
Entry
EC 1.3.1.40                 Enzyme                                 

Name
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase;
2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2,6-dioxo-6-phenylhexanoate:NADP+ Delta2-oxidoreductase
Reaction(IUBMB)
2,6-dioxo-6-phenylhexanoate + NADP+ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + NADPH + H+ [RN:R03463]
Reaction(KEGG)
Substrate
2,6-dioxo-6-phenylhexanoate [CPD:C03750];
NADP+ [CPD:C00006]
Product
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate [CPD:C01273];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Broad specificity; reduces a number of compounds produced by Pseudomonas from aromatic hydrocarbons by ring fission.
History
EC 1.3.1.40 created 1989
Reference
1
  Authors
Omori, T., Ishigooka, H. and Minoda, Y.
  Title
Purification and some properties of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid(HOPDA) reducing enzyme from Pseudomonas cruciviae S93B1 involved in the degradation of biphenyl.
  Journal
Agric. Biol. Chem. 50 (1986) 1513-1518.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
104645-83-2

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