KEGG   ENZYME: 1.3.1.48Help
Entry
EC 1.3.1.48                 Enzyme                                 
Name
15-oxoprostaglandin 13-oxidase;
15-oxo-Delta13-prostaglandin reductase;
Delta13-15-ketoprostaglandin reductase;
15-ketoprostaglandin Delta13-reductase;
prostaglandin Delta13-reductase;
prostaglandin 13-reductase;
15-ketoprostaglandin Delta13-reductase;
(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase;
(5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate:NAD(P)+ Delta13-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase
Reaction(IUBMB)
11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NAD(P)H + H+ [RN:R04556 R04557]
Reaction(KEGG)
Substrate
11alpha-hydroxy-9,15-dioxoprostanoate;
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate [CPD:C04654];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives. The enzyme from placenta is specific for NAD+.
Orthology
K13948  
prostaglandin reductase 1
K13949  
prostaglandin reductase 2
Genes
HSA: 
145482(PTGR2) 22949(PTGR1)
PTR: 
740274(PTGR1) 740765(PTGR2)
PPS: 
100972632(PTGR2) 100979208(PTGR1)
GGO: 
101147031(PTGR1) 101149819(PTGR2)
PON: 
100173198(PTGR2) 100461388(PTGR1)
MCC: 
697996(PTGR2) 708725(LTB4DH)
MMU: 
67103(Ptgr1) 77219(Ptgr2)
RNO: 
192227(Ptgr1) 299194(Ptgr2)
CFA: 
474802(PTGR1) 480383(PTGR2)
AML: 
FCA: 
101089020(PTGR2) 101093468(PTGR1)
BTA: 
506263(PTGR2) 513177(PTGR1)
SSC: 
100156930 397678(PTGR1)
ECB: 
100050600(PTGR2) 100058059
MDO: 
100017288 100024234
SHR: 
100920365 100935341(PTGR2)
OAA: 
100091372 100092763
GGA: 
423244(PTGR2) 427337(PTGR1)
MGP: 
100540778 100546799
TGU: 
100190170 100229401
ACS: 
100554853 100559950
XLA: 
446864(ptgr1.2) 495998(ptgr1.1) 496331(ptgr2)
XTR: 
100135160(ptgr1.2) 100485344 493462(ltb4dh) 780263(ptgr2)
DRE: 
494108(ptgr1) 553234
TRU: 
101068290 101078055
OLA: 
101158478 101173668
BFO: 
BRAFLDRAFT_115255 BRAFLDRAFT_276226 BRAFLDRAFT_90405
CIN: 
100179413 100182376
SPU: 
577347 578367 585482 589330 762500
AGA: 
AgaP_AGAP000288 AgaP_AGAP000414
AAG: 
AaeL_AAEL012455 AaeL_AAEL012457 AaeL_AAEL015034
CQU: 
CpipJ_CPIJ003801 CpipJ_CPIJ003802 CpipJ_CPIJ014058
AME: 
411378
NVI: 
100119006(NV17112) 100120078(NV14581)
TCA: 
657348
API: 
100162222
CEL: 
CELE_M106.3(M106.3)
CBR: 
CBG03002
BMY: 
Bm1_05625
TSP: 
Tsp_01072
NVE: 
NEMVE_v1g165928
HMG: 
100199266
TAD: 
TRIADDRAFT_28673
AQU: 
100637260 100638523
 » show all
Taxonomy
Reference
1  [PMID:6290839]
  Authors
Hansen HS.
  Title
Purification and assay of 15-ketoprostaglandin delta 13-reductase from bovine lung.
  Journal
Methods. Enzymol. 86 (1982) 156-63.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:7132753]
  Authors
Jarabak J.
  Title
Isolation and properties of a 15-ketoprostaglandin delta 13-reductase from human placenta.
  Journal
Methods. Enzymol. 86 (1982) 163-7.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
57406-74-3
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