KEGG   ENZYME: 1.3.1.51Help
Entry
EC 1.3.1.51                 Enzyme                                 

Name
2'-hydroxydaidzein reductase;
NADPH:2'-hydroxydaidzein oxidoreductase;
HDR;
2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase
Reaction(IUBMB)
2'-hydroxy-2,3-dihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+ [RN:R03962]
Reaction(KEGG)
Substrate
2'-hydroxy-2,3-dihydrodaidzein [CPD:C03567];
NADP+ [CPD:C00006]
Product
2'-hydroxydaidzein [CPD:C02495];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
In the reverse reaction, the 2'-hydroxyisoflavone (2'-hydroxydaidzein) is reduced to an isoflavanone. Also acts on 2'-hydroxyformononetin and to a small extent on 2'-hydroxygenistein. Involved in the biosynthesis of the phytoalexin glyceollin. The isoflavones biochanin A, daidzein and genestein as well as the flavonoids apigenin, kaempferol and quercetin do not act as substrates.
History
EC 1.3.1.51 created 1992, modified 2004
Pathway
Isoflavonoid biosynthesis
Reference
1  [PMID:2306102]
  Authors
Fischer D, Ebenau-Jehle C, Grisebach H.
  Title
Phytoalexin synthesis in soybean: purification and characterization of NADPH:2'-hydroxydaidzein oxidoreductase from elicitor-challenged soybean cell cultures.
  Journal
Arch. Biochem. Biophys. 276 (1990) 390-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
126125-01-7

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