KEGG   ENZYME: 1.3.1.67Help
Entry
EC 1.3.1.67                 Enzyme                                 

Name
cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NAD(P)+ = 4-methylcatechol + NAD(P)H + CO2 [RN:R05292 R05293]
Reaction(KEGG)
Substrate
cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate [CPD:C06729];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
4-methylcatechol [CPD:C06730];
NADH [CPD:C00004];
NADPH [CPD:C00005];
CO2 [CPD:C00011]
Comment
Involved in the p-xylene degradation pathway in bacteria.
History
EC 1.3.1.67 created 2000
Pathway
Xylene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Reference
1  [PMID:3711022]
  Authors
Whited GM, McCombie WR, Kwart LD, Gibson DT.
  Title
Identification of cis-diols as intermediates in the oxidation of aromatic acids by a strain of Pseudomonas putida that contains a TOL plasmid.
  Journal
J. Bacteriol. 166 (1986) 1028-39.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 

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