| Entry |
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| Name |
Delta14-sterol reductase
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ Delta14-oxidoreductase
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| Reaction(IUBMB) |
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+ [RN: R05639]
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| Reaction(KEGG) |
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| Substrate |
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol [CPD: C05108];
NADP+ [CPD: C00006]
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| Product |
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol [CPD: C11455];
NADPH [CPD: C00005];
H+ [CPD: C00080]
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| Comment |
This enzyme acts on a range of steroids with a 14(15)-double bond.
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| Pathway |
| Steroid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Orthology |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | TAD: | | AQU: | | ATH: | | ALY: | | GMX: | | CSV: | | RCU: | | POP: | | VVI: | | DOSA: | | BDI: | | SBI: | | ZMA: | | SMO: | | PPP: | | VCN: | | OLU: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | PNO: | | PTE: | | ZTR: | | TML: | | SPO: | | CNE: | | CNB: | | CGI: | | LBC: | | MPR: | | CCI: | | SCM: | | MGL: | | PGR: | | MBR: | | DDI: | | DPP: | | TET: | | PTM: | | TBR: | | TCR: | | LMA: | | LIF: | | LDO: | | LMI: | | LBZ: | | PTI: | | TPS: | | MAH: | | FRI: | |
» show all
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| Reference |
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| Authors |
Bottema CK, Parks LW. |
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| Title |
Delta14-sterol reductase in Saccharomyces cerevisiae. |
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| Journal |
Biochim. Biophys. Acta. 531 (1978) 301-7. |
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| Organism |
Saccharomyces cerevisiae [GN: sce] |
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| Reference |
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| Authors |
Paik YK, Trzaskos JM, Shafiee A, Gaylor JL. |
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| Title |
Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent delta 8,14-steroid 14-reductase. |
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| Journal |
J. Biol. Chem. 259 (1984) 13413-23. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 69403-07-2 |
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