KEGG   ENZYME: 1.3.1.70Help
Entry
EC 1.3.1.70                 Enzyme                                 

Name
Delta14-sterol reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ Delta14-oxidoreductase
Reaction(IUBMB)
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+ [RN:R05639]
Reaction(KEGG)
R05639;
(other) R07483
Show
Substrate
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol [CPD:C05108];
NADP+ [CPD:C00006]
Product
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol [CPD:C11455];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This enzyme acts on a range of steroids with a 14(15)-double bond.
History
EC 1.3.1.70 created 2001
Pathway
Steroid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K00222  
delta14-sterol reductase
Genes
HSA: 
7108(TM7SF2)
PTR: 
451314(TM7SF2)
PON: 
100436442(TM7SF2)
MCC: 
721985(TM7SF2)
RRO: 
104662828(TM7SF2)
MMU: 
73166(Tm7sf2)
RNO: 
293688(Tm7sf2)
CFA: 
476027(TM7SF2)
AML: 
100469158(TM7SF2)
BTA: 
282384(TM7SF2)
SSC: 
100514510(TM7SF2)
ECB: 
100056588(TM7SF2)
MDO: 
100030557(TM7SF2)
XLA: 
379527(tm7sf2)
XTR: 
100127815(tm7sf2)
DRE: 
494054(tm7sf2)
ATH: 
OLU: 
SCE: 
YNL280C(ERG24)
AGO: 
KLA: 
CGR: 
PPA: 
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CaO19.1598(ERG24) CaO19.9166(ERG24)
YLI: 
NCR: 
NCU08762(erg-3)
MGR: 
SSL: 
BFU: 
ANI: 
AFM: 
AOR: 
AOR_1_1256144(AO090023000728) AOR_1_596184(AO090009000362)
ANG: 
ANI_1_446164(An18g03480) ANI_1_916014(An01g07000)
PCS: 
CPW: 
URE: 
TML: 
SPO: 
CNE: 
MPR: 
MGL: 
MBR: 
DDI: 
TET: 
PTM: 
PTI: 
TPS: 
TBR: 
TCR: 
LMA: 
LIF: 
MAH: 
FRI: 
 » show all
Taxonomy
Reference
1  [PMID:32908]
  Authors
Bottema CK, Parks LW.
  Title
Delta14-sterol reductase in Saccharomyces cerevisiae.
  Journal
Biochim. Biophys. Acta. 531 (1978) 301-7.
Reference
2  [PMID:6444198]
  Authors
Paik YK, Trzaskos JM, Shafiee A, Gaylor JL.
  Title
Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent delta 8,14-steroid 14-reductase.
  Journal
J. Biol. Chem. 259 (1984) 13413-23.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
69403-07-2

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