KEGG   ENZYME: 1.3.1.71Help
Entry
EC 1.3.1.71                 Enzyme                                 

Name
Delta24(241)-sterol reductase;
sterol Delta24(28)-methylene reductase;
sterol Delta24(28)-reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
ergosterol:NADP+ Delta24(241)-oxidoreductase
Reaction(IUBMB)
ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+ [RN:R05641]
Reaction(KEGG)
Substrate
ergosterol [CPD:C01694];
NADP+ [CPD:C00006]
Product
ergosta-5,7,22,24(241)-tetraen-3beta-ol;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on a range of steroids with a 24(241)-double bond.
History
EC 1.3.1.71 created 2001, modified 2002
Pathway
Steroid biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Orthology
K00223  
Delta24(24(1))-sterol reductase
Genes
MIS: 
MPP: 
SCE: 
YGL012W(ERG4)
AGO: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A03520(NCAS0A03520)
NDI: 
NDAI_0A03360(NDAI0A03360)
TPF: 
TPHA_0F00690(TPHA0F00690)
TBL: 
TBLA_0C04060(TBLA0C04060)
TDL: 
TDEL_0F02340(TDEL0F02340)
KAF: 
KAFR_0A06700(KAFR0A06700) KAFR_0F03420(KAFR0F03420)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NTE: 
NEUTE1DRAFT57468(NEUTE1DRAFT_57468)
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1700194(AO090012000966)
ANG: 
ANI_1_1230064(An07g09690)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT112024(AGABI1DRAFT_112024)
ABV: 
AGABI2DRAFT193266(AGABI2DRAFT_193266)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
MBR: 
AAF: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
CBU: 
CBS: 
CBD: 
CBG: 
CBC: 
 » show all
Taxonomy
Reference
1  [PMID:14922]
  Authors
Neal WD, Parks LW.
  Title
Sterol 24(28) methylene reductase in Saccharomyces cerevisiae.
  Journal
J. Bacteriol. 129 (1977) 1375-8.
Reference
2  [PMID:10722850]
  Authors
Zweytick D, Hrastnik C, Kohlwein SD, Daum G.
  Title
Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae.
  Journal
FEBS. Lett. 470 (2000) 83-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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