| Entry |
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| Name |
Delta24-sterol reductase;
lanosterol Delta24-reductase
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
sterol:NADP+ Delta24-oxidoreductase
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| Reaction(IUBMB) |
5alpha-cholest-7-en-3beta-ol + NADP+ = 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+ [RN: R05703]
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| Reaction(KEGG) |
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| Substrate |
5alpha-cholest-7-en-3beta-ol [CPD: C01189];
NADP+ [CPD: C00006]
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| Product |
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| Comment |
Acts on a range of steroids with a 24(25)-double bond, including lanosterol, desmosterol and zymosterol.
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| Pathway |
| Steroid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Orthology |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | AAG: | | CQU: | | NVI: | | TCA: | | API: | | CEL: | | CBR: | | NVE: | | TAD: | | ATH: | | ALY: | | GMX: | | CSV: | | RCU: | | POP: | | VVI: | | DOSA: | | BDI: | | SBI: | | ZMA: | | SMO: | | PPP: | | MBR: | | MCA: | | MAH: | |
» show all
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| Reference |
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| Authors |
Bae SH, Paik YK. |
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| Title |
Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. |
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| Journal |
Biochem. J. 326 ( Pt 2) (1997) 609-16. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9033-57-2 |
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