KEGG   ENZYME: 1.3.1.77Help
Entry
EC 1.3.1.77                 Enzyme                                 

Name
anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming];
ANR (gene name) (ambiguous);
flavan-3-ol:NAD(P)+ oxidoreductase;
anthocyanidin reductase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2R,3R)-flavan-3-ol:NAD(P)+ 3,4-oxidoreductase
Reaction(IUBMB)
a (2R,3R)-flavan-3-ol + 2 NAD(P)+ = an anthocyanidin with a 3-hydroxy group + 2 NAD(P)H + H+ [RN:R07351 R07352]
Reaction(KEGG)
Substrate
(2R,3R)-flavan-3-ol [CPD:C15598];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
anthocyanidin with a 3-hydroxy group [CPD:C21381];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme participates in the flavonoid biosynthesis pathway found in plants. It catalyses the double reduction of anthocyanidins, producing (2R,3R)-flavan-3-ol monomers required for the formation of proanthocyanidins. While the enzyme from the legume Medicago truncatula (MtANR) can use both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana (AtANR) uses only NADPH. Also, while the substrate preference of MtANR is cyanidin>pelargonidin>delphinidin, the reverse preference is found with AtANR. cf. EC 1.3.1.112, anthocyanidin reductase [(2S)-flavan-3-ol-forming].
History
EC 1.3.1.77 created 2004, modified 2016
Pathway
Flavonoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K08695  
anthocyanidin reductase
Genes
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
106352233(A.BANb) 106374812(C.BANa) 106374840 106395425(C.BANb)
BOE: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
GHI: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj4g3v0423090.1(Lj4g3v0423090.1)
LANG: 
FVE: 
PPER: 
PMUM: 
MDM: 
103434638(ANR2a)
PXB: 
ZJU: 
RCU: 
JCU: 
POP: 
POPTR_0004s03030g(POPTRDRAFT_831060) POPTR_0011s03430g(POPTRDRAFT_834000)
SLY: 
SPEN: 
SOT: 
NTA: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os04t0630100-01(Os04g0630100) Os04t0630300-01(Os04g0630300) Os04t0630400-01(Os04g0630400) Os04t0630600-00(Os04g0630600) Os04t0630800-01(Os04g0630800) Os04t0630900-01(Os04g0630900) Os04t0631000-00(Os04g0631000)
OBR: 
BDI: 
ATS: 
SBI: 
ZMA: 
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
 » show all
Taxonomy
Reference
1  [PMID:12532018]
  Authors
Xie DY, Sharma SB, Paiva NL, Ferreira D, Dixon RA.
  Title
Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis.
  Journal
Science. 299 (2003) 396-9.
  Sequence
Reference
2  [PMID:14725861]
  Authors
Xie DY, Sharma SB, Dixon RA.
  Title
Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana.
  Journal
Arch. Biochem. Biophys. 422 (2004) 91-102.
  Sequence
[ath:AT1G61720]
Reference
3  [PMID:23288883]
  Authors
Pang Y, Abeysinghe IS, He J, He X, Huhman D, Mewan KM, Sumner LW, Yun J, Dixon RA
  Title
Functional characterization of proanthocyanidin pathway enzymes from tea and their application for metabolic engineering.
  Journal
Plant. Physiol. 161 (2013) 1103-16.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
93389-48-1

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