KEGG   ENZYME: 1.3.1.78Help
Entry
EC 1.3.1.78                 Enzyme                                 

Name
arogenate dehydrogenase (NADP+);
arogenic dehydrogenase (ambiguous);
pretyrosine dehydrogenase (ambiguous);
TyrAAT1;
TyrAAT2;
TyrAa
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-arogenate:NADP+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-arogenate + NADP+ = L-tyrosine + NADPH + CO2 [RN:R00733]
Reaction(KEGG)
Substrate
L-arogenate [CPD:C00826];
NADP+ [CPD:C00006]
Product
L-tyrosine [CPD:C00082];
NADPH [CPD:C00005];
CO2 [CPD:C00011]
Comment
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NADP+-dependent enzymes usually predominate in higher plants.The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly [2,3].
History
EC 1.3.1.78 created 2005
Pathway
Phenylalanine, tyrosine and tryptophan biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K15226  
arogenate dehydrogenase (NADP+)
K15227  
arogenate dehydrogenase (NADP+), plant
Genes
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os06t0708832-00(Os06g0708832) Os06t0709000-01(Os06g0709000)
OBR: 
BDI: 
SBI: 
SORBI_10g021300(SORBIDRAFT_10g021300) SORBI_10g029510(SORBIDRAFT_10g029510) SORBI_10g029540(SORBIDRAFT_10g029540)
ZMA: 
100276497(GRMZM2G324297) 100281038(GRMZM2G084942) 100281078(GRMZM2G365961) 100284089(GRMZM2G085117)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
CCP: 
AAF: 
SYN: 
slr2081(tyrA)
SYZ: 
SYY: 
SYT: 
SYS: 
SYQ: 
SYJ: 
SYW: 
SYC: 
syc0868_c(tyrA)
SYF: 
SYD: 
SYE: 
SYG: 
sync_0447(tyrA)
SYR: 
SYX: 
SYP: 
CYA: 
CYA_2300(tyrA)
CYB: 
CYB_0624(tyrA)
SYNE: 
SYNP: 
SYNK: 
SYNR: 
SYND: 
SYU: 
SYH: 
TEL: 
tll2435(tyrA)
THN: 
MAR: 
MPK: 
CYT: 
cce_4463(tyrA)
CYP: 
CYC: 
CYN: 
CYH: 
CYJ: 
AMR: 
AM1_2942(tyrA)
CGC: 
CAN: 
CSN: 
DSL: 
HAO: 
GLP: 
CMP: 
GEN: 
GEE: 
TER: 
LEP: 
LEN: 
LET: 
GEI: 
OAC: 
ONI: 
PSEU: 
CEP: 
MIC: 
ARP: 
GVI: 
gvip038(tyrA)
GLJ: 
GKIL_4393(tyrAa)
ANA: 
NPU: 
NOS: 
NOP: 
NON: 
AVA: 
ANB: 
ACY: 
AWA: 
NAZ: 
CSG: 
CALO: 
CALT: 
CALH: 
RIV: 
PMA: 
Pro_1719(tyrA)
PMM: 
PMT: 
PMN: 
PMI: 
PMB: 
PMC: 
PMF: 
PMG: 
PMH: 
PMJ: 
PME: 
PRC: 
PRM: 
CTHE: 
PLP: 
SCS: 
FIS: 
CEO: 
ETSB_0416(tyrA)
 » show all
Taxonomy
Reference
1
  Authors
Gaines, C.G., Byng, G.S., Whitaker, R.J. and Jensen, R.A.
  Title
L-Tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of Nicotiana silvestris Speg. et Comes.
  Journal
Planta 156 (1982) 233-240.
Reference
2  [PMID:12354106]
  Authors
Rippert P, Matringe M
  Title
Purification and kinetic analysis of the two recombinant arogenate dehydrogenase  isoforms of Arabidopsis thaliana.
  Journal
Eur. J. Biochem. 269 (2002) 4753-61.
  Sequence
Reference
3  [PMID:15171683]
  Authors
Bonner CA, Jensen RA, Gander JE, Keyhani NO.
  Title
A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis.
  Journal
Biochem. J. 382 (2004) 279-91.
  Sequence
[syn:slr2081]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
64295-75-6

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