KEGG   ENZYME: 1.3.1.79Help
Entry
EC 1.3.1.79                 Enzyme                                 

Name
arogenate dehydrogenase [NAD(P)+];
arogenic dehydrogenase (ambiguous);
cyclohexadienyl dehydrogenase;
pretyrosine dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-arogenate:NAD(P)+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2 [RN:R00732 R00733]
Reaction(KEGG)
Substrate
L-arogenate [CPD:C00826];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
L-tyrosine [CPD:C00082];
NADH [CPD:C00004];
NADPH [CPD:C00005];
CO2 [CPD:C00011]
Comment
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). Enzymes that can utilize both cofactors have been reported from some Proteobacteria, including Burkholderia caryophylli, Burkholderia cepacia, Pseudomonas marginata and Delftia acidovorans.
History
EC 1.3.1.79 created 2005
Pathway
Phenylalanine, tyrosine and tryptophan biosynthesis
Reference
1  [PMID:7419490]
  Authors
Byng GS, Whitaker RJ, Gherna RL, Jensen RA
  Title
Variable enzymological patterning in tyrosine biosynthesis as a means of determining natural relatedness among the Pseudomonadaceae.
  Journal
J. Bacteriol. 144 (1980) 247-57.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
64295-75-6

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