KEGG   ENZYME: 1.3.1.81Help
Entry
EC 1.3.1.81                 Enzyme                                 

Name
(+)-pulegone reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(-)-menthone:NADP+ oxidoreductase
Reaction(IUBMB)
(1) (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+ [RN:R06419];
(2) (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+ [RN:R06420]
Reaction(KEGG)
Substrate
(-)-menthone [CPD:C00843];
NADP+ [CPD:C00006];
(+)-isomenthone [CPD:C11952]
Product
(+)-pulegone [CPD:C09893];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
NADH cannot replace NADPH as reductant. The Delta8,9-double bond of (+)-cis-isopulegone and the Delta1,2-double bond of (+-)-piperitone are not substrates. The enzyme from peppermint (Mentha x piperita) converts (+)-pulegone into both (-)-menthone and (+)-isomenthone at a ratio of 70:30 for native enzyme but it does not catalyse the reverse reaction. This enzyme is a member of the medium-chain dehydrogenase/reductase superfamily.
History
EC 1.3.1.81 created 2008
Pathway
Monoterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K15092  
(+)-pulegone reductase
Reference
1  [PMID:13679086]
  Authors
Ringer KL, McConkey ME, Davis EM, Rushing GW, Croteau R.
  Title
Monoterpene double-bond reductases of the (-)-menthol biosynthetic pathway: isolation and characterization of cDNAs encoding (-)-isopiperitenone reductase and (+)-pulegone reductase of peppermint.
  Journal
Arch. Biochem. Biophys. 418 (2003) 80-92.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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