KEGG   ENZYME: 1.3.1.84Help
Entry
EC 1.3.1.84                 Enzyme                                 

Name
acrylyl-CoA reductase (NADPH)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
propanoyl-CoA:NADP+ oxidoreductase
Reaction(IUBMB)
propanoyl-CoA + NADP+ = acryloyl-CoA + NADPH + H+ [RN:R00919]
Reaction(KEGG)
Substrate
propanoyl-CoA [CPD:C00100];
NADP+ [CPD:C00006]
Product
acryloyl-CoA [CPD:C00894];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Sulfolobus tokodaii does not act on either NADH or crotonyl-CoA [2]. Different from EC 1.3.1.8, which acts only on enoyl-CoA derivatives of carbon chain length 4 to 16. Contains Zn2+.
History
EC 1.3.1.84 created 2009, modified 2014
Pathway
Carbon fixation pathways in prokaryotes
Microbial metabolism in diverse environments
Orthology
K14469  
acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
K15020  
acryloyl-coenzyme A reductase
Genes
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
CTM: 
CTS: 
TAC: 
TVO: 
TVG0995648(TVG0995648)
PTO: 
FAC: 
SSO: 
SSO0764(adh-2)
SOL: 
SSOA: 
SSOL: 
SSOF: 
STO: 
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
SULA: 
MSE: 
MCN: 
AHO: 
PAI: 
PIS: 
PCL: 
PAS: 
PYR: 
POG: 
TNE: 
PYW: 
CMA: 
TUZ: 
TTN: 
TTX_1731(adhP)
VDI: 
VMO: 
 » show all
Taxonomy
Reference
1  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science. 318 (2007) 1782-6.
Reference
2  [PMID:19429610]
  Authors
Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G
  Title
3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.
  Journal
J. Bacteriol. 191 (2009) 4572-81.
  Sequence
[sto:STK_04800]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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