KEGG   ENZYME: 1.3.1.86Help
Entry
EC 1.3.1.86                 Enzyme                                 

Name
crotonyl-CoA reductase;
butyryl-CoA dehydrogenase;
butyryl dehydrogenase;
unsaturated acyl-CoA reductase;
ethylene reductase;
enoyl-coenzyme A reductase;
unsaturated acyl coenzyme A reductase;
butyryl coenzyme A dehydrogenase;
short-chain acyl CoA dehydrogenase;
short-chain acyl-coenzyme A dehydrogenase;
3-hydroxyacyl CoA reductase;
butanoyl-CoA:(acceptor) 2,3-oxidoreductase;
CCR
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
butanoyl-CoA:NADP+ 2,3-oxidoreductase
Reaction(IUBMB)
butanoyl-CoA + NADP+ = (E)-but-2-enoyl-CoA + NADPH + H+ [RN:R09738]
Reaction(KEGG)
Substrate
butanoyl-CoA [CPD:C00136];
NADP+ [CPD:C00006]
Product
(E)-but-2-enoyl-CoA [CPD:C00877];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reaction in the reverse direction. This enzyme from Streptomyces collinus is specific for (E)-but-2-enoyl-CoA, and is proposed to provide butanoyl-CoA as a starter unit for straight-chain fatty acid biosynthesis.
History
EC 1.3.1.86 created 2011
Pathway
Butanoate metabolism
Orthology
K17829  
crotonyl-CoA reductase
Genes
NNO: 
TPR: 
SCO: 
SCO6473(SC9C7.09c)
SMA: 
SAV_1911(ccrA2) SAV_2890(ccrA1)
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SALU: 
SLV: 
SLIV_06060(ccrA2)
SGU: 
KSK: 
KSE_56510(ccr1) KSE_65530(ccr3) KSE_70410(ccr2)
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 » show all
Taxonomy
Reference
1  [PMID:8521864]
  Authors
Wallace KK, Bao ZY, Dai H, Digate R, Schuler G, Speedie MK, Reynolds KA
  Title
Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli.
  Journal
Eur. J. Biochem. 233 (1995) 954-62.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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