KEGG   ENZYME: 1.3.1.86Help
Entry
EC 1.3.1.86                 Enzyme                                 

Name
crotonyl-CoA reductase;
butyryl-CoA dehydrogenase;
butyryl dehydrogenase;
unsaturated acyl-CoA reductase;
ethylene reductase;
enoyl-coenzyme A reductase;
unsaturated acyl coenzyme A reductase;
butyryl coenzyme A dehydrogenase;
short-chain acyl CoA dehydrogenase;
short-chain acyl-coenzyme A dehydrogenase;
3-hydroxyacyl CoA reductase;
butanoyl-CoA:(acceptor) 2,3-oxidoreductase;
CCR
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
butanoyl-CoA:NADP+ 2,3-oxidoreductase
Reaction(IUBMB)
butanoyl-CoA + NADP+ = (E)-but-2-enoyl-CoA + NADPH + H+ [RN:R09738]
Reaction(KEGG)
Substrate
butanoyl-CoA [CPD:C00136];
NADP+ [CPD:C00006]
Product
(E)-but-2-enoyl-CoA [CPD:C00877];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reaction in the reverse direction. This enzyme from Streptomyces collinus is specific for (E)-but-2-enoyl-CoA, and is proposed to provide butanoyl-CoA as a starter unit for straight-chain fatty acid biosynthesis.
History
EC 1.3.1.86 created 2011
Pathway
Butanoate metabolism
Microbial metabolism in diverse environments
Biosynthesis of antibiotics
Orthology
K17829  
crotonyl-CoA reductase
Genes
ANT: 
DDS: 
DOA: 
RSU: 
NHU_00907(ttmP)
NNO: 
RFA: 
TPR: 
SCO: 
SCO6473(SC9C7.09c)
SMA: 
SAV_1911(ccrA2) SAV_2890(ccrA1)
SGR: 
SGB: 
SCB: 
SSX: 
SVL: 
SCT: 
SCY: 
SFA: 
SBH: 
SHY: 
SHO: 
SVE: 
SDV: 
SALB: 
SALS: 
STRP: 
SFI: 
SCI: 
SRC: 
SALU: 
SALL: 
SLV: 
SLIV_06060(ccrA2)
SGU: 
SVT: 
STRE: 
SCW: 
SLD: 
SXI: 
STRM: 
STRC: 
SAMB: 
SPRI: 
SCZ: 
SCX: 
SRW: 
TUE45_01107(ccr_1) TUE45_07075(ccr_2)
STRF: 
SLE: 
sle_13020(sle_13020) sle_22910(sle_22910)
SRN: 
SPAV: 
SLC: 
STRT: 
SGS: 
KSK: 
KSE_56510(ccr1) KSE_65530(ccr3) KSE_70410(ccr2)
ICA: 
ARS: 
JTE: 
NCA: 
NDK: 
I601_3892(ccr_1)
KFL: 
PSIM: 
AER: 
NAL: 
TCU: 
SRO: 
FRA: 
FRE: 
FRI: 
FAL: 
FSY: 
GOB: 
BSD: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
AJA: 
AMQ: 
ALU: 
PDX: 
PSEA: 
PSEE: 
PSEH: 
PSEQ: 
PECQ: 
PHH: 
AMI: 
SESP: 
KAL: 
KPHY: 
LED: 
AHM: 
ACTI: 
ACAD: 
ALL: 
STP: 
SAQ: 
MAU: 
MIL: 
ACTN: 
CAI: 
SNA: 
AFO: 
AYM: 
ABAI: 
 » show all
Taxonomy
Reference
1  [PMID:8521864]
  Authors
Wallace KK, Bao ZY, Dai H, Digate R, Schuler G, Speedie MK, Reynolds KA
  Title
Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli.
  Journal
Eur. J. Biochem. 233 (1995) 954-62.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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