KEGG   ENZYME: 1.3.1.87Help
Entry
EC 1.3.1.87                 Enzyme                                 

Name
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase;
hcaB (gene name);
cis-dihydrodiol dehydrogenase;
2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase
Reaction(IUBMB)
(1) 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ = 3-(2,3-dihydroxyphenyl)propanoate + NADH + H+ [RN:R06784];
(2) (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD+ = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H+ [RN:R06785]
Reaction(KEGG)
Substrate
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate [CPD:C11588];
NAD+ [CPD:C00003];
(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate [CPD:C12622]
Product
3-(2,3-dihydroxyphenyl)propanoate [CPD:C04044];
NADH [CPD:C00004];
H+ [CPD:C00080];
(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate [CPD:C12623]
Comment
This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation.
History
EC 1.3.1.87 created 2011
Pathway
Phenylalanine metabolism
Microbial metabolism in diverse environments
Orthology
K05711  
2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase
Genes
ECO: 
b2541(hcaB)
ECJ: 
JW2525(hcaB)
ECD: 
EBW: 
BWG_2305(hcaB)
ECOK: 
ECE: 
Z3813(hcaB)
ECS: 
ECF: 
ETW: 
ECSP_3485(hcaB)
ELX: 
EOJ: 
EOI: 
EOH: 
EOK: 
ELR: 
ECX: 
ECW: 
ECM: 
ECY: 
ECR: 
ECK: 
ECT: 
EOC: 
CE10_2973(hcaB)
EUM: 
ELO: 
ELH: 
ESO: 
ESM: 
ESL: 
ECL: 
EBR: 
ECB_02433(hcaB)
EBD: 
EKO: 
EKF: 
EDH: 
EDJ: 
EUN: 
ELW: 
ECW_m2767(hcaB)
ELL: 
WFL_13550(hcaB)
ELP: 
EBL: 
ECD_02433(hcaB)
EBE: 
B21_02397(hcaB)
ECOA: 
ECOL: 
SFL: 
SF2588(hcaB)
SFX: 
S2760(hcaB)
SFV: 
SFV_2589(hcaB)
SFE: 
SFxv_2844(hcaB)
SFN: 
SFS: 
SFT: 
SSN: 
SSON_2623(hcaB)
SSJ: 
SBO: 
SBO_2565(hcaB)
PLU: 
plu2207(hcaB)
PAY: 
PAU_02354(hcaB)
CFD: 
EBF: 
DEL: 
BTS: 
MPA: 
MAP_2736(fabG5)
MAV: 
MVA: 
MAB: 
MKM: 
ROP: 
SCB: 
SCAB_2141(hcaB)
NCA: 
FRI: 
TRO: 
 » show all
Taxonomy
Reference
1  [PMID:9603882]
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J. Bacteriol. 180 (1998) 2915-23.
  Sequence
[eco:b2541]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 

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