KEGG   ENZYME: 1.3.1.87Help
Entry
EC 1.3.1.87                 Enzyme                                 

Name
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase;
hcaB (gene name);
cis-dihydrodiol dehydrogenase;
2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase
Reaction(IUBMB)
(1) 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ = 3-(2,3-dihydroxyphenyl)propanoate + NADH + H+ [RN:R06784];
(2) (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD+ = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H+ [RN:R06785]
Reaction(KEGG)
Substrate
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate [CPD:C11588];
NAD+ [CPD:C00003];
(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate [CPD:C12622]
Product
3-(2,3-dihydroxyphenyl)propanoate [CPD:C04044];
NADH [CPD:C00004];
H+ [CPD:C00080];
(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate [CPD:C12623]
Comment
This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation.
History
EC 1.3.1.87 created 2011
Pathway
ec00360  Phenylalanine metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K05711  2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase
Genes
ECO: b2541(hcaB)
ECJ: JW2525(hcaB)
ECD: ECDH10B_2708(hcaB)
EBW: BWG_2305(hcaB)
ECOK: ECMDS42_2085(hcaB)
ECE: Z3813(hcaB)
ECS: ECs3407
ECF: ECH74115_3773(hcaB)
ETW: ECSP_3485(hcaB)
ELX: CDCO157_3174
EOJ: ECO26_3588(hcaB)
EOI: ECO111_3265(hcaB)
EOH: ECO103_3061(hcaB)
EOK: G2583_3071(hcaB)
ECX: EcHS_A2693(hcaB)
ECW: EcE24377A_2826(hcaB)
ECM: EcSMS35_2694(hcaB)
ECY: ECSE_2828
ECR: ECIAI1_2593(hcaB)
ECK: EC55989_2827(hcaB)
ECT: ECIAI39_2742(hcaB)
EOC: CE10_2973(hcaB)
EUM: ECUMN_2861(hcaB)
ELO: EC042_2745(hcaB)
ELH: ETEC_2698
ESO: O3O_18940
ESM: O3M_06755
ESL: O3K_06710
EBR: ECB_02433(hcaB)
EBD: ECBD_1143
EKF: KO11_10115(hcaB)
EDJ: ECDH1ME8569_2468(hcaB)
ELW: ECW_m2767(hcaB)
ELL: WFL_13550(hcaB)
ELP: P12B_c2641(hcaB)
EBL: ECD_02433(hcaB)
EBE: B21_02397(hcaB)
SFL: SF2588(hcaB)
SFX: S2760(hcaB)
SFV: SFV_2589(hcaB)
SFE: SFxv_2844(hcaB)
SFN: SFy_3675
SFS: SFyv_3752
SFT: NCTC1_02844(hcaB)
SSN: SSON_2623(hcaB)
SBO: SBO_2565(hcaB)
EBF: D782_1128
PLU: plu2207(hcaB)
PAY: PAU_02354(hcaB)
BTS: Btus_2899
MPA: MAP_2736(fabG5)
MAV: MAV_3512
MKM: Mkms_5615
MVA: Mvan_4412
MAB: MAB_4365c
ROP: ROP_pROB02-02080(narB)
SCB: SCAB_2141(hcaB)
NCA: Noca_0689
TRO: trd_A0926
 » show all
Taxonomy
Reference
1  [PMID:9603882]
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J. Bacteriol. 180 (1998) 2915-23.
  Sequence
[eco:b2541]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.87
IUBMB Enzyme Nomenclature: 1.3.1.87
ExPASy - ENZYME nomenclature database: 1.3.1.87
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.87
BRENDA, the Enzyme Database: 1.3.1.87

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