| Entry |
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| Name |
tRNA-dihydrouridine16/17 synthase [NAD(P)+];
Dus1p;
tRNA-dihydrouridine synthase 1
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
tRNA-5,6-dihydrouracil16/17:NAD(P)+ oxidoreductase
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| Reaction(IUBMB) |
(1) 5,6-dihydrouracil16 in tRNA + NAD(P)+ = uracil16 in tRNA + NAD(P)H + H+;
(2) 5,6-dihydrouracil17 in tRNA + NAD(P)+ = uracil17 in tRNA + NAD(P)H + H+
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| Substrate |
5,6-dihydrouracil16 in tRNA;
NAD+ [CPD: C00003];
NADP+ [CPD: C00006];
5,6-dihydrouracil17 in tRNA
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| Product |
uracil16 in tRNA;
NADH [CPD: C00004];
NADPH [CPD: C00005];
H+ [CPD: C00080];
uracil17 in tRNA
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| Comment |
A flavoprotein. The enzyme specifically modifies uracil16 and uracil17 in tRNA.
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| Orthology |
| tRNA-dihydrouridine synthase 1 |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | TCA: | | API: | | PHU: | | ISC: | | CEL: | | CBR: | | BMY: | | TSP: | | SMM: | | NVE: | | HMG: | | TAD: | | AQU: | | ATH: | | ALY: | | GMX: | | CSV: | | RCU: | | POP: | | VVI: | | OSA: | | DOSA: | | BDI: | | SBI: | | ZMA: | | SMO: | | PPP: | | CRE: | | VCN: | | OLU: | | CME: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | ZTR: | | TML: | | SPO: | | CNE: | | CNB: | | CGI: | | PPL: | | LBC: | | MPR: | | CCI: | | SCM: | | UMA: | | MGL: | | ECU: | | EIN: | | EHE: | | NCE: | | MBR: | | NGR: | | DDI: | | DPP: | | EHI: | | EDI: | | TGO: | | TET: | | PTM: | | GLA: | | TVA: | | PTI: | | TPS: | | PIF: | |
» show all
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| Reference |
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| Authors |
Xing F, Hiley SL, Hughes TR, Phizicky EM |
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| Title |
The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. |
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| Journal |
J. Biol. Chem. 279 (2004) 17850-60. |
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| Organism |
Saccharomyces cerevisiae [GN: sce] |
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| Reference |
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| Authors |
Xing F, Martzen MR, Phizicky EM |
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| Title |
A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. |
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| Journal |
RNA. 8 (2002) 370-81. |
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| Organism |
Saccharomyces cerevisiae [GN: sce] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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