KEGG   ENZYME: 1.3.1.91Help
Entry
EC 1.3.1.91                 Enzyme                                 

Name
tRNA-dihydrouridine20 synthase [NAD(P)+];
Dus2p;
tRNA-dihydrouridine synthase 2
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
tRNA-5,6-dihydrouracil20:NAD(P)+ oxidoreductase
Reaction(IUBMB)
5,6-dihydrouracil20 in tRNA + NAD(P)+ = uracil20 in tRNA + NAD(P)H + H+
Substrate
5,6-dihydrouracil20 in tRNA;
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
uracil20 in tRNA;
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A flavoenzyme [3]. The enzyme specifically modifies uracil20 in tRNA.
History
EC 1.3.1.91 created 2011
Orthology
K05543  tRNA-dihydrouridine synthase 2
Genes
HSA: 54920(DUS2)
PTR: 743213(DUS2)
PPS: 100984987(DUS2)
GGO: 101142497(DUS2)
PON: 100456658(DUS2)
NLE: 100605309(DUS2)
MCC: 702051(DUS2)
MCF: 102128929(DUS2)
CSAB: 103233245(DUS2)
RRO: 104655603(DUS2)
RBB: 108515372(DUS2)
CJC: 100390345(DUS2)
SBQ: 101048779(DUS2)
MMU: 66369(Dus2)
RNO: 291978(Dus2)
CGE: 100750570(Dus2)
NGI: 103734995(Dus2)
HGL: 101697323(Dus2)
CCAN: 109691259(Dus2)
OCU: 100354521(DUS2)
TUP: 102478923(DUS2)
CFA: 489746(DUS2)
AML: 100479999(DUS2)
UMR: 103673634(DUS2)
ORO: 101379473(DUS2)
FCA: 101091831(DUS2)
PTG: 102972392(DUS2)
AJU: 106971880(DUS2)
BTA: 509795(DUS2)
BOM: 102287531(DUS2)
BIU: 109572713(DUS2)
PHD: 102320924(DUS2)
CHX: 102190541(DUS2)
OAS: 101117185(DUS2)
SSC: 100621573(DUS2)
CFR: 102520826(DUS2)
CDK: 105088417(DUS2)
BACU: 103017440(DUS2)
LVE: 103080495(DUS2)
OOR: 101284411(DUS2)
ECB: 100053802(DUS2)
EPZ: 103549707(DUS2)
EAI: 106822495(DUS2)
MYB: 102264054(DUS2)
MYD: 102767129(DUS2)
HAI: 109389570(DUS2)
RSS: 109460742(DUS2)
PALE: 102883296(DUS2)
LAV: 100665142(DUS2)
TMU: 101352856
MDO: 100021875(DUS2)
SHR: 100917216(DUS2)
OAA: 100080263
GGA: 415712(DUS2)
MGP: 100545996(DUS2)
CJO: 107319202(DUS2)
APLA: 101795479(DUS2)
ACYG: 106043100(DUS2)
TGU: 100221777(DUS2)
GFR: 102038499(DUS2)
FAB: 101813298(DUS2)
PHI: 102105439(DUS2)
PMAJ: 107209893(DUS2)
CCW: 104687479(DUS2)
FPG: 101912027(DUS2)
FCH: 102050185(DUS2)
CLV: 102090003(DUS2)
EGZ: 104125203(DUS2)
AAM: 106483190(DUS2)
ASN: 102370055(DUS2)
AMJ: 102559011(DUS2)
PSS: 102447408(DUS2)
CMY: 102942500(DUS2)
CPIC: 101933400(DUS2)
ACS: 100564134(dus2)
PVT: 110085512(DUS2)
PBI: 103048913(DUS2)
GJA: 107105787(DUS2)
XLA: 108713981(dus2.L)
XTR: 548984(dus2)
DRE: 100003049(dus2)
SRX: 107723992(dus2) 107752485
SANH: 107679963 107694839(dus2)
CCAR: 109053331 109091290(dus2)
IPU: 108275366(dus2)
AMEX: 103030766(dus2)
TRU: 101077485(dus2)
LCO: 104927019(dus2) 109141067
MZE: 101468180(dus2)
OLA: 101158438(dus2)
XMA: 102222993(dus2)
PRET: 103465667(dus2)
NFU: 107388396(dus2)
CSEM: 103379768(dus2)
LCF: 108872673(dus2)
HCQ: 109507935(dus2)
SASA: 106561520(dus2)
ELS: 105018091(dus2)
SFM: 108928301(dus2)
LCM: 102356367(DUS2)
CMK: 103176108(dus2)
CIN: 100176105
SPU: 579041
APLC: 110980051
SKO: 102801906
DSI: Dsimw501_GD17163(Dsim_GD17163)
MDE: 101893979
AAG: 5575869
AME: 410264
BIM: 100741583
BTER: 100644611
SOC: 105203969
AEC: 105148164
ACEP: 105624784
PBAR: 105424120
HST: 105182805
CFO: 105256625
LHU: 105667402
PGC: 109858194
NVI: 100118176
TCA: 658663
DPA: 109534018
NVL: 108556341
PMAC: 106710730
PRAP: 110998673
PXY: 105387354
API: 100160203
ZNE: 110826696
FCD: 110848619
TUT: 107362147
CEL: CELE_Y54E5A.6(dus-2)
CBR: CBG19749
BMY: Bm1_02370
TSP: Tsp_01302
CRG: 105334707
MYI: 110443785
OBI: 106875714
SHX: MS3_03222
EPA: 110236622
ADF: 107349544
HMG: 100203367
AQU: 100640958
ATH: AT3G49640
CRB: 17884872
BRP: 103873037
BOE: 106307664
THJ: 104798453
CPAP: 110809067
CIT: 102628574
TCC: 18611388
GRA: 105787730
GHI: 107950501
DZI: 111292609
EGR: 104414087
VRA: 106778712
VAR: 108347102
CCAJ: 109806435
CAM: 101505275
ADU: 107472010
AIP: 107623418
LJA: Lj0g3v0165759.1(Lj0g3v0165759.1)
LANG: 109350253
PPER: 18777077
PMUM: 103336703
PAVI: 110772751
PXB: 103955551
ZJU: 107425071
CSV: 101220446
CMO: 103484905
MCHA: 111005266
CMAX: 111497209
CMOS: 111463056
CPEP: 111781070
RCU: 8288720
JCU: 105642060
HBR: 110646015
JRE: 108984024
SLY: 101254211
SPEN: 107020981
SOT: 102599476
CANN: 107875760
NTA: 107798641
NSY: 104229823
NTO: 104102779
INI: 109177919
SIND: 105177865
OEU: 111409006
HAN: 110868125
LSV: 111900243
DCR: 108196000
BVG: 104897814
SOE: 110804529
NNU: 104595575
OSA: 4336488
DOSA: Os04t0531300-01(Os04g0531300)
OBR: 102720321
BDI: 100837531
ATS: 109737317(LOC109737317)
SBI: 8056045
ZMA: 100193915(si614032g01)
SITA: 101756824
PDA: 103708392
EGU: 105034560
MUS: 103971623
DCT: 110112634
AOF: 109837017
ATR: 18421628
SCE: YNR015W(SMM1)
ERC: Ecym_2108
KMX: KLMA_60468(SMM1)
NCS: NCAS_0A04620(NCAS0A04620)
NDI: NDAI_0K01680(NDAI0K01680)
TPF: TPHA_0D03720(TPHA0D03720)
TBL: TBLA_0A06710(TBLA0A06710)
TDL: TDEL_0A07250(TDEL0A07250)
KAF: KAFR_0F00830(KAFR0F00830)
CAL: CAALFM_C209890WA(SMM1)
CAUR: QG37_03042
SLB: AWJ20_2393(SMM1)
NCR: NCU00950
NTE: NEUTE1DRAFT125714(NEUTE1DRAFT_125714)
MGR: MGG_01648
MAW: MAC_01002
MAJ: MAA_05731
CMT: CCM_02317
BFU: BCIN_01g02930(Bcsmm1)
MBE: MBM_02507
ANI: AN2967.2
ANG: ANI_1_3106024(An02g12030)
ABE: ARB_00495
TVE: TRV_01589
PTE: PTT_12265
SPO: SPBC1709.06(dus2)
CNE: CNE02870
CNB: CNBE2890
ABP: AGABI1DRAFT110775(AGABI1DRAFT_110775)
ABV: AGABI2DRAFT189317(AGABI2DRAFT_189317)
MGL: MGL_3988
DDI: DDB_G0283877(dus2l)
DFA: DFA_07012(dus2l)
EHI: EHI_023240(444.t00003)
SMIN: v1.2.036354.t1(symbB.v1.2.036354.t1)
 » show all
Taxonomy
Reference
1  [PMID:14970222]
  Authors
Xing F, Hiley SL, Hughes TR, Phizicky EM
  Title
The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs.
  Journal
J. Biol. Chem. 279 (2004) 17850-60.
  Sequence
[sce:YNR015W]
Reference
2  [PMID:12003496]
  Authors
Xing F, Martzen MR, Phizicky EM
  Title
A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA.
  Journal
RNA. 8 (2002) 370-81.
  Sequence
[sce:YNR015W]
Reference
3  [PMID:19139092]
  Authors
Rider LW, Ottosen MB, Gattis SG, Palfey BA
  Title
Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction.
  Journal
J. Biol. Chem. 284 (2009) 10324-33.
Reference
4  [PMID:15994936]
  Authors
Kato T, Daigo Y, Hayama S, Ishikawa N, Yamabuki T, Ito T, Miyamoto M, Kondo S, Nakamura Y
  Title
A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis.
  Journal
Cancer. Res. 65 (2005) 5638-46.
  Sequence
[hsa:54920]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.91
IUBMB Enzyme Nomenclature: 1.3.1.91
ExPASy - ENZYME nomenclature database: 1.3.1.91
BRENDA, the Enzyme Database: 1.3.1.91

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