KEGG   ENZYME: 1.3.1.92Help
Entry
EC 1.3.1.92                 Enzyme                                 

Name
artemisinic aldehyde Delta11(13)-reductase;
Dbr2
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
artemisinic aldehyde:NADP+ oxidoreductase
Reaction(IUBMB)
(11R)-dihydroartemisinic aldehyde + NADP+ = artemisinic aldehyde + NADPH + H+ [RN:R10075]
Reaction(KEGG)
Substrate
(11R)-dihydroartemisinic aldehyde [CPD:C20325];
NADP+ [CPD:C00006]
Product
artemisinic aldehyde [CPD:C20308];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Cloned from Artemisia annua. In addition to the reduction of artemisinic aldehyde it is also able to a lesser extent to reduce artemisinic alcohol and artemisinic acid. Part of the biosyntheis of artemisinin.
History
EC 1.3.1.92 created 2012
Reference
1  [PMID:15678372]
  Authors
Bertea CM, Freije JR, van der Woude H, Verstappen FW, Perk L, Marquez V, De Kraker JW, Posthumus MA, Jansen BJ, de Groot A, Franssen MC, Bouwmeester HJ
  Title
Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua.
  Journal
Planta. Med. 71 (2005) 40-7.
Reference
2  [PMID:18495659]
  Authors
Zhang Y, Teoh KH, Reed DW, Maes L, Goossens A, Olson DJ, Ross AR, Covello PS
  Title
The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role  in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua.
  Journal
J. Biol. Chem. 283 (2008) 21501-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system