KEGG   ENZYME: 1.3.1.95Help
Entry
EC 1.3.1.95                 Enzyme                                 

Name
acrylyl-CoA reductase (NADH)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
propanoyl-CoA:NAD+ oxidoreductase
Reaction(IUBMB)
propanoyl-CoA + NAD+ = acryloyl-CoA + NADH + H+ [RN:R10161]
Reaction(KEGG)
Substrate
propanoyl-CoA [CPD:C00100];
NAD+ [CPD:C00003]
Product
acryloyl-CoA [CPD:C00894];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Contains FAD. The reaction is catalysed in the opposite direction to that shown. The enzyme from the bacterium Clostridium propionicum is a complex that includes an electron-transfer flavoprotein (ETF). The ETF is reduced by NADH and transfers the electrons to the active site. Catalyses a step in a pathway for L-alanine fermentation to propanoate [1]. cf. EC 1.3.1.84, acrylyl-CoA reductase (NADPH).
History
EC 1.3.1.95 created 2012
Pathway
Propanoate metabolism
Metabolic pathways
Orthology
K20143  
acrylyl-CoA reductase (NADH)
Reference
1  [PMID:12603323]
  Authors
Hetzel M, Brock M, Selmer T, Pierik AJ, Golding BT, Buckel W
  Title
Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein.
  Journal
Eur. J. Biochem. 270 (2003) 902-10.
Reference
2  [PMID:22810300]
  Authors
Kandasamy V, Vaidyanathan H, Djurdjevic I, Jayamani E, Ramachandran KB, Buckel W, Jayaraman G, Ramalingam S
  Title
Engineering Escherichia coli with acrylate pathway genes for propionic acid synthesis and its impact on mixed-acid fermentation.
  Journal
Appl. Microbiol. Biotechnol.  (2012) .
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system