KEGG   ENZYME: 1.3.1.96Help
Entry
EC 1.3.1.96                 Enzyme                                 

Name
Botryococcus squalene synthase;
SSL-2 (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
squalene:NADP+ oxidoreductase
Reaction(IUBMB)
squalene + diphosphate + NADP+ = presqualene diphosphate + NADPH + H+ [RN:R02872]
Reaction(KEGG)
Substrate
squalene [CPD:C00751];
diphosphate [CPD:C00013];
NADP+ [CPD:C00006]
Product
presqualene diphosphate [CPD:C03428];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Isolated from the green alga Botryococcus braunii BOT22. Acts in the reverse direction. cf. EC 2.5.1.21, squalene synthase, where squalene is formed directly from farnesyl diphosphate.
History
EC 1.3.1.96 created 2012
Reference
1  [PMID:21746901]
  Authors
Niehaus TD, Okada S, Devarenne TP, Watt DS, Sviripa V, Chappell J
  Title
Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 108 (2011) 12260-5.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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