KEGG   ENZYME: 1.3.3.10Help
Entry
EC 1.3.3.10                 Enzyme                                 

Name
tryptophan alpha,beta-oxidase;
L-tryptophan 2',3'-oxidase;
L-tryptophan alpha,beta-dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
L-tryptophan:oxygen alpha,beta-oxidoreductase
Reaction(IUBMB)
L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2 [RN:R05317]
Reaction(KEGG)
Substrate
L-tryptophan [CPD:C00078];
O2 [CPD:C00007]
Product
alpha,beta-didehydrotryptophan [CPD:C06732];
H2O2 [CPD:C00027]
Comment
Requires heme. The enzyme from Chromobacterium violaceum is specific for tryptophan derivatives possessing its carboxyl group free or as an amide or ester, and an unsubstituted indole ring. Also catalyses the alpha,beta dehydrogenation of L-tryptophan side chains in peptides. The product of the reaction can hydrolyse spontaneously to form (indol-3-yl)pyruvate.
History
EC 1.3.3.10 created 2000 as EC 1.4.3.17, transferred 2003 to EC 1.3.3.10
Reference
1  [PMID:8027079]
  Authors
Genet R, Denoyelle C, Menez A.
  Title
Purification and partial characterization of an amino acid alpha,beta- dehydrogenase, L-tryptophan 2',3'-oxidase from Chromobacterium violaceum.
  Journal
J. Biol. Chem. 269 (1994) 18177-84.
Reference
2  [PMID:7559518]
  Authors
Genet R, Benetti PH, Hammadi A, Menez A.
  Title
L-tryptophan 2',3'-oxidase from Chromobacterium violaceum. Substrate specificity and mechanistic implications.
  Journal
J. Biol. Chem. 270 (1995) 23540-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
156859-19-7

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