KEGG   ENZYME: 1.3.3.12Help
Entry
EC 1.3.3.12                 Enzyme                                 

Name
L-galactonolactone oxidase;
L-galactono-1,4-lactone oxidase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
L-galactono-1,4-lactone:oxygen 3-oxidoreductase
Reaction(IUBMB)
L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2 [RN:R00643]
Reaction(KEGG)
Substrate
L-galactono-1,4-lactone [CPD:C01115];
O2 [CPD:C00007]
Product
L-ascorbate [CPD:C00072];
H2O2 [CPD:C00027]
Comment
A flavoprotein. Acts on the 1,4-lactones of L-galactonic, D-altronic, L-fuconic, D-arabinic and D-threonic acids; not identical with EC 1.1.3.8 L-gulonolactone oxidase. (cf. EC 1.3.2.3 galactonolactone dehydrogenase).
History
EC 1.3.3.12 created 1984 as EC 1.1.3.24, transferred 2006 to EC 1.3.3.12
Pathway
Ascorbate and aldarate metabolism
Metabolic pathways
Reference
1  [PMID:6754380]
  Authors
Bleeg HS, Christensen F.
  Title
Biosynthesis of ascorbate in yeast. Purification of L-galactono-1,4-lactone oxidase with properties different from mammalian L-gulonolactone oxidase.
  Journal
Eur. J. Biochem. 127 (1982) 391-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
69403-13-0

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