KEGG   ENZYME: 1.3.3.12Help
Entry
EC 1.3.3.12                 Enzyme                                 

Name
L-galactonolactone oxidase;
L-galactono-1,4-lactone oxidase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
L-galactono-1,4-lactone:oxygen 3-oxidoreductase
Reaction(IUBMB)
L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2 [RN:R00643]
Reaction(KEGG)
Substrate
L-galactono-1,4-lactone [CPD:C01115];
O2 [CPD:C00007]
Product
L-ascorbate [CPD:C00072];
H2O2 [CPD:C00027]
Comment
A flavoprotein. Acts on the 1,4-lactones of L-galactonic, D-altronic, L-fuconic, D-arabinic and D-threonic acids; not identical with EC 1.1.3.8 L-gulonolactone oxidase. (cf. EC 1.3.2.3 galactonolactone dehydrogenase).
History
EC 1.3.3.12 created 1984 as EC 1.1.3.24, transferred 2006 to EC 1.3.3.12
Pathway
Ascorbate and aldarate metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K05276  
L-galactonolactone oxidase
Genes
TCR: 
Taxonomy
Reference
1  [PMID:6754380]
  Authors
Bleeg HS, Christensen F.
  Title
Biosynthesis of ascorbate in yeast. Purification of L-galactono-1,4-lactone oxidase with properties different from mammalian L-gulonolactone oxidase.
  Journal
Eur. J. Biochem. 127 (1982) 391-6.
  Organism
Saccharomyces cerevisiae
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
69403-13-0

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