KEGG   ENZYME: 1.3.7.1Help
Entry
EC 1.3.7.1                  Enzyme                                 

Name
6-hydroxynicotinate reductase;
6-oxotetrahydronicotinate dehydrogenase;
6-hydroxynicotinic reductase;
HNA reductase;
1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase
Reaction(IUBMB)
6-oxo-1,4,5,6-tetrahydronicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin [RN:R03164]
Reaction(KEGG)
Substrate
6-oxo-1,4,5,6-tetrahydronicotinate [CPD:C04226];
oxidized ferredoxin [CPD:C00139]
Product
6-hydroxynicotinate [CPD:C01020];
reduced ferredoxin [CPD:C00138]
History
EC 1.3.7.1 created 1972
Pathway
Nicotinate and nicotinamide metabolism
Microbial metabolism in diverse environments
Orthology
K20449  
6-hydroxynicotinate reductase
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Taxonomy
Reference
1  [PMID:5767303]
  Authors
Holcenberg JS, Tsai L.
  Title
Nicotinic acid metabolism. IV. Ferredoxin-dependent reduction of 6-hydroxynicotinic acid to 6-oxo-1,4,5,6-tetrahydronicotinic acid.
  Journal
J. Biol. Chem. 244 (1969) 1204-11.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9030-84-6

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