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Entry
EC 1.3.7.5                  Enzyme                                 

Name
phycocyanobilin:ferredoxin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
(3Z)-phycocyanobilin:ferredoxin oxidoreductase
Reaction(IUBMB)
(3Z)-phycocyanobilin + 4 oxidized ferredoxin = biliverdin IXalpha + 4 reduced ferredoxin [RN:R05817]
Reaction(KEGG)
Substrate
(3Z)-phycocyanobilin [CPD:C05786];
oxidized ferredoxin [CPD:C00139]
Product
biliverdin IXalpha;
reduced ferredoxin [CPD:C00138]
Comment
Catalyses the four-electron reduction of biliverdin IXalpha (2-electron reduction at both the A and D rings). Reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin. Flavodoxins can be used instead of ferredoxin. The direct conversion of biliverdin IXalpha (BV) to (3Z)-phycocyanolbilin (PCB) in the cyanobacteria Synechocystis sp. PCC 6803, Anabaena sp. PCC7120 and Nostoc punctiforme is in contrast to the proposed pathways of PCB biosynthesis in the red alga Cyanidium caldarium, which involves (3Z)-phycoerythrobilin (PEB) as an intermediate [2] and in the green alga Mesotaenium caldariorum, in which PCB is an isolable intermediate.
History
EC 1.3.7.5 created 2002, modified 2014
Pathway
Porphyrin and chlorophyll metabolism
Orthology
K05371  
phycocyanobilin:ferredoxin oxidoreductase
Genes
CCRO: 
BRA: 
SYN: 
SYZ: 
SYY: 
SYNGTS_2691(slr0116)
SYT: 
SYNGTI_2690(slr0116)
SYS: 
SYNPCCN_2689(slr0116)
SYQ: 
SYNPCCP_2689(slr0116)
SYJ: 
SYW: 
SYNW1084(PcyA)
SYC: 
SYF: 
SYD: 
SYE: 
SYG: 
sync_1656(pcyA)
SYR: 
SYX: 
SYP: 
CYA: 
CYA_2492(pcyA)
CYB: 
CYB_0698(pcyA)
SYNE: 
SYNP: 
SYNK: 
SYNR: 
SYND: 
SYU: 
SYH: 
TEL: 
THN: 
CGC: 
DSL: 
CMP: 
LEP: 
LEN: 
LET: 
PSEU: 
PMA: 
Pro_0819(pcyA)
PMM: 
PMM0747(pcyA)
PMT: 
PMN: 
PMI: 
PMB: 
PMC: 
PMF: 
PMG: 
PMH: 
PMJ: 
PME: 
PRC: 
PRM: 
AMR: 
AM1_5311(pcyA)
MAR: 
MAE_06540(pcyA)
MPK: 
CAN: 
CSN: 
HAO: 
CYU: 
GLP: 
GEN: 
GEE: 
CYT: 
CYP: 
CYC: 
CYN: 
CYH: 
CYJ: 
TER: 
MIC: 
ARP: 
GEI: 
OAC: 
ONI: 
MPRO: 
CEP: 
GVI: 
gvip359(pcyA)
GLJ: 
GKIL_0241(pcyA)
ANA: 
NPU: 
NOS: 
NOP: 
NON: 
AVA: 
ANB: 
ACY: 
AWA: 
NAZ: 
CSG: 
CALO: 
CALT: 
CALH: 
RIV: 
FIS: 
CTHE: 
PLP: 
SCS: 
 » show all
Taxonomy
Reference
1  [PMID:11283349]
  Authors
Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.
  Title
Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.
  Journal
Plant. Cell. 13 (2001) 965-78.
  Sequence
[npu:Npun_R5577] [ana:alr3707] [pmm:PMM0747]
Reference
2
  Authors
Beale, S.I.
  Title
Biosynthesis of phycobilins.
  Journal
Chem. Rev. 93 (1993) 785-802.
Reference
3  [PMID:9325294]
  Authors
Wu SH, McDowell MT, Lagarias JC.
  Title
Phycocyanobilin is the natural precursor of the phytochrome chromophore in the green alga Mesotaenium caldariorum.
  Journal
J. Biol. Chem. 272 (1997) 25700-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
347401-12-1

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