| Entry |
|
|---|
| Name |
phycocyanobilin:ferredoxin oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
 |
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| Sysname |
(3Z)-phycocyanobilin:ferredoxin oxidoreductase |
|---|
| Reaction(IUBMB) |
(3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXalpha +
reduced ferredoxin [RN:R05817] |
|---|
| Reaction(KEGG) |
R05817
 |
|---|
| Substrate |
(3Z)-phycocyanobilin [CPD:C05786];
oxidized ferredoxin [CPD:C00139] |
|---|
| Product |
biliverdin IXalpha;
reduced ferredoxin [CPD:C00138] |
|---|
| Comment |
Catalyses the four-electron reduction of biliverdin IXalpha
(2-electron reduction at both the A and D rings). Reaction proceeds
via an isolatable 2-electron intermediate,
181,182-dihydrobiliverdin. Flavodoxins can be used instead of
ferredoxin.The direct conversion of biliverdin IXalpha (BV) to
(3Z)-phycocyanolbilin (PCB) in the cyanobacteria Synechocystis sp
PCC 6803, Anabaena sp PCC7120 and Nostoc punctiforme is in contrast
to the proposed pathways of PCB biosynthesis in the red alga
Cyanidium caldarium, which involves (3Z)-phycoerythrobilin (PEB) as
an intermediate [2] and in the green alga Mesotaenium caldariorum,
in which PCB is an isolable intermediate. |
|---|
| Pathway |
ec00860 Porphyrin and chlorophyll metabolism |
|---|
| Orthology |
K05371 phycocyanobilin:ferredoxin oxidoreductase |
|---|
| Genes |
BRA: BRADO1265
SYN: slr0116
SYW: SYNW1084(pcyA)
SYC: syc0325_d
SYF: Synpcc7942_1225
SYD: Syncc9605_1216
SYE: Syncc9902_1253
SYG: sync_1656(pcyA)
SYR: SynRCC307_1284(pcyA)
SYX: SynWH7803_1335(pcyA)
SYP: SYNPCC7002_A2228
CYA: CYA_2492(pcyA)
CYB: CYB_0698(pcyA)
TEL: tll2308
MAR: MAE_06540(pcyA)
CYT: cce_3569
CYP: PCC8801_1724
CYC: PCC7424_1047
CYN: Cyan7425_4845
CYH: Cyan8802_1748
CYU: UCYN_02910
GVI: gvip359(pcyA)
ANA: alr3707
NPU: Npun_R5577
AVA: Ava_3585
NAZ: Aazo_0093
PMA: Pro0819(pcyA)
PMM: PMM0747(pcyA)
PMT: PMT0590(pcyA)
PMN: PMN2A_0151
PMI: PMT9312_0755
PMB: A9601_08081(pcyA)
PMC: P9515_08371(pcyA)
PMF: P9303_16581(pcyA)
PMG: P9301_08071(pcyA)
PMH: P9215_08411(pcyA)
PMJ: P9211_10161
PME: NATL1_07831(pcyA)
TER: Tery_4156
AMR: AM1_5311(pcyA)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:11283349]
Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.
Functional genomic analysis of the HY2 family of
ferredoxin-dependent bilin reductases from oxygenic photosynthetic
organisms.
Plant. Cell. 13 (2001) 965-78.
Nostoc punctiforme [GN:npu], Anabaena sp., Synechocystis sp.
[GN:syn] |
|---|
Reference
Authors
Title
Journal
|
2
Beale, S.I.
Biosynthesis of phycobilins.
Chem. Rev. 93 (1993) 785-802. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:9325294]
Wu SH, McDowell MT, Lagarias JC.
Phycocyanobilin is the natural precursor of the phytochrome
chromophore in the green alga Mesotaenium caldariorum.
J. Biol. Chem. 272 (1997) 25700-5.
Mesotaenium caldariorum |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.3.7.5
IUBMB Enzyme Nomenclature: 1.3.7.5
ExPASy - ENZYME nomenclature database: 1.3.7.5
BRENDA, the Enzyme Database: 1.3.7.5
CAS: 347401-12-1 |
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