KEGG   ENZYME: 1.3.7.8Help
Entry
EC 1.3.7.8                  Enzyme                                 

Name
benzoyl-CoA reductase;
benzoyl-CoA reductase (dearomatizing)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming)
Reaction(IUBMB)
cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 ADP + 2 phosphate = benzoyl-CoA + reduced ferredoxin + 2 ATP + 2 H2O [RN:R02451]
Reaction(KEGG)
R02451;
(other) R00283
Show
Substrate
cyclohexa-1,5-diene-1-carbonyl-CoA [CPD:C06322];
oxidized ferredoxin [CPD:C00139];
ADP [CPD:C00008];
phosphate [CPD:C00009]
Product
benzoyl-CoA [CPD:C00512];
reduced ferredoxin [CPD:C00138];
ATP [CPD:C00002];
H2O [CPD:C00001]
Comment
An iron-sulfur protein. Requires Mg2+ or Mn2+. Inactive towards aromatic acids that are not CoA esters but will also catalyse the reaction: ammonia + acceptor + 2 ADP + 2 phosphate = hydroxylamine + reduced acceptor + 2 ATP + H2O. In the presence of reduced acceptor, but in the absence of oxidizable substrate, the enzyme catalyses the hydrolysis of ATP to ADP plus phosphate.
History
EC 1.3.7.8 created 1999 as EC 1.3.99.15, transferred 2011 to EC 1.3.7.8, modified 2011
Pathway
Benzoate degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K04112  
benzoyl-CoA reductase subunit C
K04113  
benzoyl-CoA reductase subunit B
K04114  
benzoyl-CoA reductase subunit A
K04115  
benzoyl-CoA reductase subunit D
Genes
EBA: 
ebA5282(bcrC) ebA5284(bcrB) ebA5286(bcrD) ebA5287(bcrA) ebA742(bcrA) ebA744(bcrD) ebA748(bcrC)
TMZ: 
GLO: 
RPA: 
RPA0657(badD) RPA0658(badE) RPA0659(badF) RPA0660(badG)
RPC: 
RPD: 
RPE: 
RPT: 
RPX: 
RVA: 
MAG: 
SLP: 
FPL: 
 » show all
Taxonomy
Reference
1  [PMID:8575453]
  Authors
Boll M, Fuchs G.
  Title
Benzoyl-coenzyme A reductase (dearomatizing), a key enzyme of anaerobic aromatic metabolism. ATP dependence of the reaction, purification and some properties of the enzyme from Thauera aromatica strain K172.
  Journal
Eur. J. Biochem. 234 (1995) 921-33.
  Organism
Thauera aromatica
  Sequence
Reference
2  [PMID:20578740]
  Authors
Kung JW, Baumann S, von Bergen M, Muller M, Hagedoorn PL, Hagen WR, Boll M
  Title
Reversible biological Birch reduction at an extremely low redox potential.
  Journal
J. Am. Chem. Soc. 132 (2010) 9850-6.
  Organism
Geobacter metallireducens [GN:gme]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
176591-18-7

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