KEGG   ENZYME: 1.3.7.8Help
Entry
EC 1.3.7.8                  Enzyme                                 

Name
benzoyl-CoA reductase;
benzoyl-CoA reductase (dearomatizing)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming)
Reaction(IUBMB)
cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 ADP + 2 phosphate = benzoyl-CoA + reduced ferredoxin + 2 ATP + 2 H2O [RN:R02451]
Reaction(KEGG)
R02451;
(other) R00283
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Substrate
cyclohexa-1,5-diene-1-carbonyl-CoA [CPD:C06322];
oxidized ferredoxin [CPD:C00139];
ADP [CPD:C00008];
phosphate [CPD:C00009]
Product
benzoyl-CoA [CPD:C00512];
reduced ferredoxin [CPD:C00138];
ATP [CPD:C00002];
H2O [CPD:C00001]
Comment
An iron-sulfur protein. Requires Mg2+ or Mn2+. Inactive towards aromatic acids that are not CoA esters but will also catalyse the reaction: ammonia + acceptor + 2 ADP + 2 phosphate = hydroxylamine + reduced acceptor + 2 ATP + H2O. In the presence of reduced acceptor, but in the absence of oxidizable substrate, the enzyme catalyses the hydrolysis of ATP to ADP plus phosphate.
History
EC 1.3.7.8 created 1999 as EC 1.3.99.15, transferred 2011 to EC 1.3.7.8, modified 2011
Pathway
ec00362  Benzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04112  benzoyl-CoA reductase subunit C
K04113  benzoyl-CoA reductase subunit B
K04114  benzoyl-CoA reductase subunit A
K04115  benzoyl-CoA reductase subunit D
Genes
EBA: ebA5282(bcrC) ebA5284(bcrB) ebA5286(bcrD) ebA5287(bcrA) ebA742(bcrA) ebA744(bcrD) ebA748(bcrC)
TMZ: Tmz1t_2948 Tmz1t_2949 Tmz1t_2950 Tmz1t_2951
GLO: Glov_2400 Glov_2401
RPA: RPA0657(badD) RPA0658(badE) RPA0659(badF) RPA0660(badG)
RPC: RPC_1026 RPC_1027 RPC_1028 RPC_1029
RPD: RPD_1535 RPD_1536 RPD_1537 RPD_1538
RPE: RPE_0605 RPE_0606 RPE_0607 RPE_0608
RPT: Rpal_0724 Rpal_0725 Rpal_0726 Rpal_0727
RPX: Rpdx1_4126 Rpdx1_4127 Rpdx1_4128 Rpdx1_4129
RVA: Rvan_0037 Rvan_0038 Rvan_0039 Rvan_0040
 » show all
Taxonomy
Reference
1  [PMID:8575453]
  Authors
Boll M, Fuchs G.
  Title
Benzoyl-coenzyme A reductase (dearomatizing), a key enzyme of anaerobic aromatic metabolism. ATP dependence of the reaction, purification and some properties of the enzyme from Thauera aromatica strain K172.
  Journal
Eur. J. Biochem. 234 (1995) 921-33.
  Sequence
Reference
2  [PMID:20578740]
  Authors
Kung JW, Baumann S, von Bergen M, Muller M, Hagedoorn PL, Hagen WR, Boll M
  Title
Reversible biological Birch reduction at an extremely low redox potential.
  Journal
J. Am. Chem. Soc. 132 (2010) 9850-6.
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.8
IUBMB Enzyme Nomenclature: 1.3.7.8
ExPASy - ENZYME nomenclature database: 1.3.7.8
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.7.8
BRENDA, the Enzyme Database: 1.3.7.8
CAS: 176591-18-7

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