KEGG   ENZYME: 1.3.8.3Help
Entry
EC 1.3.8.3                  Enzyme                                 

Name
(R)-benzylsuccinyl-CoA dehydrogenase;
BbsG;
(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
(R)-benzylsuccinyl-CoA:electron transfer flavoprotein oxidoreductase
Reaction(IUBMB)
(R)-2-benzylsuccinyl-CoA + electron-transfer flavoprotein = (E)-2-benzylidenesuccinyl-CoA + reduced electron-transfer flavoprotein
Reaction(KEGG)
(other) R05584
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Substrate
(R)-2-benzylsuccinyl-CoA [CPD:C09817];
electron-transfer flavoprotein [CPD:C04253]
Product
(E)-2-benzylidenesuccinyl-CoA [CPD:C09818];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Requires FAD as prosthetic group. Unlike other acyl-CoA dehydrogenases, this enzyme exhibits high substrate- and enantiomer specificity; it is highly specific for (R)-benzylsuccinyl-CoA and is inhibited by (S)-benzylsuccinyl-CoA. Forms the third step in the anaerobic toluene metabolic pathway in Thauera aromatica. Ferricenium ion is an effective artificial electron acceptor.
History
EC 1.3.8.3 created 2003 as EC 1.3.99.21, transferred 2012 to EC 1.3.8.3
Pathway
Toluene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K07545  
(R)-benzylsuccinyl-CoA dehydrogenase
Genes
VEI: 
EBA: 
c2A310(bbsG)
AZI: 
GME: 
Gmet_1523(bbsG)
GEO: 
Geob_2422(bbsG)
DTO: 
Taxonomy
Reference
1  [PMID:10589736]
  Authors
Leutwein C, Heider J.
  Title
Anaerobic toluene-catabolic pathway in denitrifying Thauera aromatica: activation and beta-oxidation of the first intermediate, (R)-(+)-benzylsuccinate.
  Journal
Microbiology. 145 ( Pt 11) (1999) 3265-71.
Reference
2  [PMID:12420174]
  Authors
Leutwein C, Heider J.
  Title
(R)-Benzylsuccinyl-CoA dehydrogenase of Thauera aromatica, an enzyme of the anaerobic toluene catabolic pathway.
  Journal
Arch. Microbiol. 178 (2002) 517-24.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 

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