KEGG   ENZYME: 1.3.8.5Help
Entry
EC 1.3.8.5                  Enzyme                                 

Name
2-methyl-branched-chain-enoyl-CoA reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
2-methyl-branched-chain-acyl-CoA:electron-transfer flavoprotein 2-oxidoreductase
Reaction(IUBMB)
2-methylbutanoyl-CoA + electron-transfer flavoprotein = (E)-2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+ [RN:R03169]
Reaction(KEGG)
Substrate
2-methylbutanoyl-CoA [CPD:C01033];
electron-transfer flavoprotein [CPD:C04253]
Product
(E)-2-methylbut-2-enoyl-CoA;
reduced electron-transfer flavoprotein [CPD:C04570];
H+ [CPD:C00080]
Comment
A flavoprotein (FAD) from Ascaris suum. The enzyme functions in shuttling reducing power from the electron-transport chain to 2-methyl branched-chain enoyl CoA
History
EC 1.3.8.5 created 1992 as EC 1.3.1.52, transferred 2012 to EC 1.3.8.5
Reference
1  [PMID:3988734]
  Authors
Komuniecki R, Fekete S, Thissen-Parra J.
  Title
Purification and characterization of the 2-methyl branched-chain Acyl-CoA dehydrogenase, an enzyme involved in NADH-dependent enoyl-CoA reduction in anaerobic mitochondria of the nematode, Ascaris suum.
  Journal
J. Biol. Chem. 260 (1985) 4770-7.
Reference
2  [PMID:2736251]
  Authors
Komuniecki R, McCrury J, Thissen J, Rubin N.
  Title
Electron-transfer flavoprotein from anaerobic Ascaris suum mitochondria and its role in NADH-dependent 2-methyl branched-chain enoyl-CoA reduction.
  Journal
Biochim. Biophys. Acta. 975 (1989) 127-31.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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