KEGG   ENZYME: 1.3.8.8Help
Entry
EC 1.3.8.8                  Enzyme                                 

Name
long-chain acyl-CoA dehydrogenase;
palmitoyl-CoA dehydrogenase;
palmitoyl-coenzyme A dehydrogenase;
long-chain acyl-coenzyme A dehydrogenase;
long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase;
ACADL (gene name).
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
a long-chain acyl-CoA + electron-transfer flavoprotein = a long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein [RN:R00392]
Reaction(KEGG)
Substrate
long-chain acyl-CoA [CPD:C02843];
electron-transfer flavoprotein [CPD:C04253]
Product
long-chain trans-2,3-dehydroacyl-CoA;
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 6 to at least 16 carbon atoms. The highest activity was found with C12, and the rates with C8 and C16 were 80 and 70%, respectively [2]. The enzyme from rat can accept substrates with C8-C22. It is most active with C14 and C16, and has no activity with C4, C6 or C24 [4]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.
History
EC 1.3.8.8 created 1989 as EC 1.3.99.13, part transferred 2012 to EC 1.3.8.8
Pathway
Fatty acid degradation
Metabolic pathways
Orthology
K00255  
long-chain-acyl-CoA dehydrogenase
Genes
HSA: 
33(ACADL)
PTR: 
459914(ACADL)
PPS: 
100986924(ACADL)
GGO: 
101127206(ACADL)
PON: 
100440170(ACADL)
MCC: 
MCF: 
102134056(ACADL)
MMU: 
11363(Acadl)
RNO: 
25287(Acadl)
CGE: 
HGL: 
101698104(Acadl)
TUP: 
102478785(ACADL)
CFA: 
478895(ACADL)
AML: 
FCA: 
101098884(ACADL)
BTA: 
614508(ACADL)
BOM: 
102266624(ACADL)
PHD: 
102344708(ACADL)
CHX: 
102176568(ACADL)
SSC: 
396931(ACADL)
CFR: 
102511378(ACADL)
ECB: 
MYB: 
102260528(ACADL)
MDO: 
SHR: 
OAA: 
GGA: 
424005(ACADL)
MGP: 
TGU: 
100224317(ACADL)
FAB: 
101817085(ACADL)
PHI: 
102106512(ACADL)
APLA: 
101801335(ACADL)
FPG: 
101924862(ACADL)
FCH: 
102047187(ACADL)
CLV: 
102095816(ACADL)
ASN: 
102387928(ACADL)
PSS: 
102461956(ACADL)
ACS: 
XLA: 
446669(acadl)
XTR: 
734116(acadl)
DRE: 
394156(acadl)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102362263(ACADL)
BFO: 
CIN: 
SPU: 
MBR: 
EHX: 
ACI: 
ACB: 
ABM: 
ABY: 
BUR: 
SIL: 
RDE: 
RD1_3970(fadE)
NAR: 
MAV: 
MUL: 
MUL_3367(fadE20)
MVA: 
RHA: 
RER: 
RER_27750(fadE)
RSA: 
FAL: 
SEN: 
RRS: 
RCA: 
 » show all
Taxonomy
Reference
1  [PMID:13239683]
  Authors
CRANE FL, HAUGE JG, BEINERT H
  Title
Flavoproteins involved in the first oxidative step of the fatty acid cycle.
  Journal
Biochim. Biophys. Acta. 17 (1955) 292-4.
Reference
2  [PMID:13319294]
  Authors
HAUGE JG, CRANE FL, BEINERT H.
  Title
On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A.  III.  Palmityl coA dehydrogenase.
  Journal
J. Biol. Chem. 219 (1956) 727-33.
Reference
3  [PMID:1015826]
  Authors
Hall CL, Heijkenskjold L, Bartfai T, Ernster L, Kamin H.
  Title
Acyl coenzyme A dehydrogenases and electron-transferring flavoprotein from beef hart mitochondria.
  Journal
Arch. Biochem. Biophys. 177 (1976) 402-14.
Reference
4  [PMID:3968063]
  Authors
Ikeda Y, Okamura-Ikeda K, Tanaka K.
  Title
Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme.
  Journal
J. Biol. Chem. 260 (1985) 1311-25.
Reference
5  [PMID:8155643]
  Authors
Djordjevic S, Dong Y, Paschke R, Frerman FE, Strauss AW, Kim JJ
  Title
Identification of the catalytic base in long chain acyl-CoA dehydrogenase.
  Journal
Biochemistry. 33 (1994) 4258-64.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
59536-74-2

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