KEGG   ENZYME: 1.3.8.9Help
Entry
EC 1.3.8.9                  Enzyme                                 

Name
very-long-chain acyl-CoA dehydrogenase;
ACADVL (gene name).
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
very-long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
a very-long-chain acyl-CoA + electron-transfer flavoprotein = a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Reaction(KEGG)
(other) R01279 R03990
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Substrate
very-long-chain acyl-CoA [CPD:C20876];
electron-transfer flavoprotein [CPD:C04253]
Product
very-long-chain trans-2,3-dehydroacyl-CoA [CPD:C20879];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme is most active toward long-chain acyl-CoAs such as C14, C16 and C18, but is also active with very-long-chain acyl-CoAs up to 24 carbons. It shows no activity for substrates of less than 12 carbons. Its specific activity towards palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase [1]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.8, long-chain acyl-CoA dehydrogenase.
History
EC 1.3.8.9 created 1961 as EC 1.3.2.2, transferred 1964 to EC 1.3.99.3, part transferred 2012 to EC 1.3.8.9
Pathway
ec00071  Fatty acid degradation
ec01100  Metabolic pathways
Orthology
K09479  very long chain acyl-CoA dehydrogenase
Genes
HSA: 37(ACADVL)
PTR: 455237(ACADVL)
PPS: 100986379(ACADVL)
GGO: 101143346(ACADVL)
PON: 100454381(ACADVL)
NLE: 100585921(ACADVL)
MCC: 714326(ACADVL)
CSAB: 103242278(ACADVL)
RRO: 104673335(ACADVL)
RBB: 108514298(ACADVL)
CJC: 100399197(ACADVL)
SBQ: 101028298(ACADVL)
MMU: 11370(Acadvl)
RNO: 25363(Acadvl)
CGE: 100767527(Acadvl)
NGI: 103752159(Acadvl)
HGL: 101707761(Acadvl)
CCAN: 109674520(Acadvl)
OCU: 100346654(ACADVL)
TUP: 102486032(ACADVL)
CFA: 489463(ACADVL)
AML: 100472785(ACADVL)
UMR: 103660348(ACADVL)
ORO: 101376612(ACADVL)
FCA: 101094144(ACADVL)
PTG: 102968012(ACADVL)
AJU: 106972414(ACADVL)
BTA: 282130(ACADVL)
BIU: 109573934(ACADVL)
PHD: 102343749(ACADVL)
CHX: 102181987(ACADVL)
OAS: 101117173(ACADVL)
SSC: 100520636(ACADVL)
CFR: 102516576(ACADVL)
CDK: 105103048(ACADVL)
BACU: 103000307(ACADVL)
LVE: 103077095(ACADVL)
OOR: 101275668(ACADVL)
ECB: 100061583(ACADVL)
EPZ: 103557744(ACADVL)
EAI: 106844174(ACADVL)
MYB: 102257348(ACADVL)
MYD: 102774563(ACADVL)
HAI: 109394616(ACADVL)
RSS: 109454445(ACADVL)
PALE: 102879612(ACADVL)
LAV: 100657276(ACADVL)
TMU: 101361348
MDO: 100016619(ACADVL)
SHR: 100925698 100931501(ACADVL)
OAA: 100089853(ACADVL)
AAM: 106485823(ACADVL)
ASN: 102371669 102384902(ACADVL)
AMJ: 102568802(ACADVL) 102576922
PSS: 102443861(ACADVL) 102456803
CMY: 102938508(ACADVL)
CPIC: 101946768 101948805(ACADVL)
PVT: 110082312(ACADVL)
PBI: 103051941 103059781(ACADVL)
GJA: 107118083(ACADVL) 107125630
XLA: 108711808(acadvl.L)
DRE: 573723(acadvl)
IPU: 108267840(acadvl)
AMEX: 103045531(acadvl)
TRU: 101069830(acadvl)
LCO: 104937817(acadvl)
MZE: 101472773(acadvl)
OLA: 101165349(acadvl)
XMA: 102217028(acadvl)
PRET: 103480485(acadvl)
NFU: 107372430(acadvl)
CSEM: 103386901(acadvl)
LCF: 108897054(acadvl)
HCQ: 109506947(acadvl)
BPEC: 110157677(acadvl)
SASA: 106602820(acadvl)
ELS: 105010800(acadvl)
SFM: 108918781(acadvl) 108923151
LCM: 102364546(ACADVL)
CIN: 100183990
SPU: 584710
APLC: 110981027
SKO: 100369524
DSI: Dsimw501_GD11444(Dsim_GD11444)
MDE: 101891231
AME: 412025
BIM: 100747671
BTER: 100651720
SOC: 105200554
AEC: 105149521
ACEP: 105622411
PBAR: 105429882
HST: 105188087
CFO: 105251587
LHU: 105667331
PGC: 109854598
NVI: 100116828
TCA: 659957
DPA: 109541041
BMOR: 101744941
PMAC: 106710891
PRAP: 110996061
API: 100162051
DNX: 107164135
ZNE: 110832869
FCD: 110843829
TUT: 107362076
CEL: CELE_E04F6.5(acdh-12)
CBR: CBG13088
BMY: Bm1_24055
TSP: Tsp_10283
CRG: 105344745
MYI: 110463202
OBI: 106875659
EPA: 110251159
ADF: 107343075
HMG: 100201063
AQU: 100638454
 » show all
Taxonomy
Reference
1  [PMID:1730632]
  Authors
Izai K, Uchida Y, Orii T, Yamamoto S, Hashimoto T
  Title
Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase.
  Journal
J. Biol. Chem. 267 (1992) 1027-33.
  Sequence
[rno:25363]
Reference
2  [PMID:7769092]
  Authors
Aoyama T, Souri M, Ushikubo S, Kamijo T, Yamaguchi S, Kelley RI, Rhead WJ, Uetake K, Tanaka K, Hashimoto T
  Title
Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients.
  Journal
J. Clin. Invest. 95 (1995) 2465-73.
  Sequence
[hsa:37]
Reference
3  [PMID:18227065]
  Authors
McAndrew RP, Wang Y, Mohsen AW, He M, Vockley J, Kim JJ
  Title
Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase.
  Journal
J. Biol. Chem. 283 (2008) 9435-43.
  Sequence
[hsa:37]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.9
IUBMB Enzyme Nomenclature: 1.3.8.9
ExPASy - ENZYME nomenclature database: 1.3.8.9
BRENDA, the Enzyme Database: 1.3.8.9

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