KEGG   ENZYME: 1.3.99.12Help
Entry
EC 1.3.99.12                Enzyme                                 

Name
2-methylacyl-CoA dehydrogenase;
branched-chain acyl-CoA dehydrogenase;
2-methyl branched chain acyl-CoA dehydrogenase;
2-methylbutanoyl-CoA:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With other, unknown, acceptors
BRITE hierarchy
Sysname
2-methylbutanoyl-CoA:acceptor oxidoreductase
Reaction(IUBMB)
2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor [RN:R03173]
Reaction(KEGG)
R03173 > R03172;
(other) R02661
Show
Substrate
2-methylbutanoyl-CoA [CPD:C01033];
acceptor [CPD:C00028]
Product
2-methylbut-2-enoyl-CoA [CPD:C03345];
reduced acceptor [CPD:C00030]
Comment
Also oxidizes 2-methylpropanoyl-CoA. Not identical with EC 1.3.8.1 (butyryl-CoA dehydrogenase), EC 1.3.8.7 (medium-chain acyl-CoA dehydrogenase), EC 1.3.8.8 (long-chain acyl-CoA dehydrogenase), EC 1.3.8.9 (very-long-chain acyl-CoA dehydrogenase) or EC 1.3.99.10 (isovaleryl-CoA dehydrogenase).
History
EC 1.3.99.12 created 1986
Pathway
Valine, leucine and isoleucine degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K09478  
short/branched chain acyl-CoA dehydrogenase
K11410  
short/branched chain acyl-CoA dehydrogenase
Genes
HSA: 
36(ACADSB)
PTR: 
745464(ACADSB)
PPS: 
100991276(ACADSB)
GGO: 
101132470(ACADSB)
PON: 
100171571(ACADSB)
NLE: 
100603582(ACADSB)
MCC: 
707487(ACADSB)
MCF: 
102133754(ACADSB)
CJC: 
100396089(ACADSB)
MMU: 
66885(Acadsb)
RNO: 
25618(Acadsb)
CGE: 
100766828(Acadsb)
NGI: 
103729261(Acadsb)
HGL: 
101698912(Acadsb)
OCU: 
100351868(ACADSB)
TUP: 
102474463(ACADSB)
CFA: 
477856(ACADSB)
AML: 
UMR: 
103657958(ACADSB)
FCA: 
101092794(ACADSB)
PTG: 
102951023(ACADSB)
BTA: 
504301(ACADSB)
BOM: 
102266366(ACADSB)
PHD: 
CHX: 
102177588(ACADSB)
OAS: 
101102606(ACADSB)
SSC: 
100154810(ACADSB)
CFR: 
102517479(ACADSB)
BACU: 
102999342(ACADSB)
LVE: 
103077062(ACADSB)
ECB: 
100057998(ACADSB)
MYB: 
102253452(ACADSB)
MYD: 
102769159(ACADSB)
PALE: 
102891849(ACADSB)
MDO: 
100025277(ACADSB)
SHR: 
OAA: 
100086999(ACADSB)
GGA: 
423947(ACADSB)
MGP: 
APLA: 
101793844(ACADSB)
TGU: 
100217590(ACADSB)
FAB: 
101819094(ACADSB)
PHI: 
102100927(ACADSB)
FPG: 
101917969(ACADSB)
FCH: 
102057808(ACADSB)
CLV: 
102096980(ACADSB)
ASN: 
102386096(ACADSB)
AMJ: 
102577069(ACADSB)
PSS: 
102458654(ACADSB)
CMY: 
102942130(ACADSB)
ACS: 
100556766(acadsb)
PBI: 
103066261(ACADSB)
XTR: 
448259(acadsb)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102365761(ACADSB)
CMK: 
103185437(acadsb)
BFO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
409712(GB11251)
NVI: 
TCA: 
BMOR: 
733139(Acade)
API: 
PHU: 
CEL: 
CELE_K06A5.6(acdh-3)
CBR: 
TSP: 
LGI: 
NVE: 
HMG: 
TAD: 
AQU: 
CME: 
DDI: 
DDB_G0282967(acadsb)
DPP: 
DFA: 
DFA_08597(acadsb)
ACAN: 
TGO: 
PTI: 
TPS: 
PIF: 
EHX: 
NGR: 
SCO: 
SCO2779(acdH)
SMA: 
SAV_5275(fadE4)
SGR: 
ACM: 
CTM: 
 » show all
Taxonomy
Reference
1  [PMID:6401712]
  Authors
Ikeda Y, Dabrowski C, Tanaka K.
  Title
Separation and properties of five distinct acyl-CoA dehydrogenases from rat liver mitochondria. Identification of a new 2-methyl branched chain acyl-CoA dehydrogenase.
  Journal
J. Biol. Chem. 258 (1983) 1066-76.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
85130-32-1

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