KEGG   ENZYME: 1.3.99.12Help
Entry
EC 1.3.99.12                Enzyme                                 
Name
2-methylacyl-CoA dehydrogenase;
branched-chain acyl-CoA dehydrogenase;
2-methyl branched chain acyl-CoA dehydrogenase;
2-methylbutanoyl-CoA:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With other acceptors
BRITE hierarchy
Sysname
2-methylbutanoyl-CoA:acceptor oxidoreductase
Reaction(IUBMB)
2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor [RN:R03173]
Reaction(KEGG)
R03173 > R03172;
(other) R02661
Show
Substrate
2-methylbutanoyl-CoA [CPD:C01033];
acceptor [CPD:C00028]
Product
2-methylbut-2-enoyl-CoA [CPD:C03345];
reduced acceptor [CPD:C00030]
Comment
Also oxidizes 2-methylpropanoyl-CoA. Not identical with EC 1.3.8.1 (butyryl-CoA dehydrogenase), EC 1.3.8.7 (medium-chain acyl-CoA dehydrogenase), EC 1.3.8.8 (long-chain acyl-CoA dehydrogenase), EC 1.3.8.9 (very-long-chain acyl-CoA dehydrogenase) or EC 1.3.99.10 (isovaleryl-CoA dehydrogenase).
Pathway
Valine, leucine and isoleucine degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K09478  
short/branched chain acyl-CoA dehydrogenase
K11410  
short/branched chain acyl-CoA dehydrogenase
Genes
HSA: 
36(ACADSB)
PTR: 
745464(ACADSB)
PPS: 
100991276(ACADSB)
GGO: 
101132470(ACADSB)
PON: 
100171571(ACADSB)
MCC: 
707487(ACADSB)
MMU: 
66885(Acadsb)
RNO: 
25618(Acadsb)
CFA: 
477856(ACADSB)
AML: 
FCA: 
101092794(ACADSB)
BTA: 
504301(ACADSB)
SSC: 
100154810(ACADSB)
ECB: 
100057998
MDO: 
100025277
SHR: 
100925751
OAA: 
100086999
GGA: 
423947(ACADSB)
MGP: 
100542282
TGU: 
100217590(ACADSB)
ACS: 
100556766
XTR: 
448259(acadsb)
TRU: 
101075946
OLA: 
101163855
BFO: 
BRAFLDRAFT_74917
DME: 
Dmel_CG3902
DPO: 
Dpse_GA17761
DAN: 
Dana_GF10801
DER: 
Dere_GG13447
DPE: 
Dper_GL25250
DSE: 
Dsec_GM14915
DSI: 
Dsim_GD12323
DWI: 
Dwil_GK20439
DYA: 
Dyak_GE22545 Dyak_GE22549
DGR: 
Dgri_GH16965
DMO: 
Dmoj_GI11829
DVI: 
Dvir_GJ13529
AGA: 
AgaP_AGAP009783
AAG: 
AaeL_AAEL007555
CQU: 
CpipJ_CPIJ009148
AME: 
409712
NVI: 
100120366(NV18020)
TCA: 
657543 660569
API: 
100161123
PHU: 
Phum_PHUM226870
CEL: 
CELE_K06A5.6(acdh-3)
CBR: 
CBG12633 CBG12644(Cbr-acdh-1) CBG12664
TSP: 
Tsp_04649
NVE: 
NEMVE_v1g118418
HMG: 
100205931
TAD: 
TRIADDRAFT_58518
AQU: 
100640316
NGR: 
NAEGRDRAFT_56367
DDI: 
DDB_G0282967(acadsb)
DPP: 
DICPUDRAFT_44750
TGO: 
TGME49_066270
PTI: 
PHATRDRAFT_20310
TPS: 
THAPSDRAFT_269127(ACD3)
PIF: 
PITG_06732
SCO: 
SCO2779(acdH)
SMA: 
SAV_5275(fadE4)
SGR: 
SGR_4756
ACM: 
AciX9_0500
CTM: 
Cabther_A0832
 » show all
Taxonomy
Reference
1  [PMID:6401712]
  Authors
Ikeda Y, Dabrowski C, Tanaka K.
  Title
Separation and properties of five distinct acyl-CoA dehydrogenases from rat liver mitochondria. Identification of a new 2-methyl branched chain acyl-CoA dehydrogenase.
  Journal
J. Biol. Chem. 258 (1983) 1066-76.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
85130-32-1
DBGET integrated database retrieval system