KEGG   ENZYME: 1.3.99.19Help
Entry
EC 1.3.99.19                Enzyme                                 

Name
quinoline-4-carboxylate 2-oxidoreductase;
quinaldic acid 4-oxidoreductase;
quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With other acceptors
BRITE hierarchy
Sysname
quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)
Reaction(IUBMB)
quinoline-4-carboxylate + acceptor + H2O = 2-oxo-1,2-dihydroquinoline-4-carboxylate + reduced acceptor [RN:R05183]
Reaction(KEGG)
Substrate
quinoline-4-carboxylate [CPD:C06414];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product
2-oxo-1,2-dihydroquinoline-4-carboxylate [CPD:C16715];
reduced acceptor [CPD:C00030]
Comment
A molybdenum---iron---sulfur flavoprotein with molybdopterin cytosine dinucleotide as the molybdenum cofactor. Quinoline, 4-methylquinoline and 4-chloroquinoline can also serve as substrates for the enzyme from Agrobacterium sp. 1B. Iodonitrotetrazolium chloride, thionine, menadione and 2,6-dichlorophenolindophenol can act as electron acceptors.
History
EC 1.3.99.19 created 1999, modified 2006
Reference
1  [PMID:1418685]
  Authors
Bauer G, Lingens F.
  Title
Microbial metabolism of quinoline and related compounds. XV. Quinoline-4-carboxylic acid oxidoreductase from Agrobacterium spec.1B: a molybdenum-containing enzyme.
  Journal
Biol. Chem. Hoppe. Seyler. 373 (1992) 699-705.
  Organism
Agrobacterium sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
175780-18-4

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