KEGG   ENZYME: 1.3.99.23Help
Entry
EC 1.3.99.23                Enzyme                                 

Name
all-trans-retinol 13,14-reductase;
retinol saturase;
RetSat;
(13,14)-all-trans-retinol saturase;
all-trans-retinol:all-trans-13,14-dihydroretinol saturase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With other, unknown, acceptors
BRITE hierarchy
Sysname
all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase
Reaction(IUBMB)
all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor [RN:R07163]
Reaction(KEGG)
Substrate
all-trans-13,14-dihydroretinol [CPD:C15492];
acceptor [CPD:C00028]
Product
all-trans-retinol [CPD:C00473];
reduced acceptor [CPD:C00030]
Comment
The reaction is only known to occur in the opposite direction to that given above, with the enzyme being specific for all-trans-retinol as substrate. Neither all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers are substrates. May play a role in the metabolism of vitamin A.
History
EC 1.3.99.23 created 2005
Pathway
Retinol metabolism
Orthology
K09516  
all-trans-retinol 13,14-reductase
Genes
HSA: 
54884(RETSAT)
PTR: 
470420(RETSAT)
PPS: 
100980971(RETSAT)
GGO: 
101149338(RETSAT)
PON: 
100433966(RETSAT)
MCC: 
695058(RETSAT)
MCF: 
102124463(RETSAT)
MMU: 
67442(Retsat)
RNO: 
246298(Retsat)
CGE: 
100750576(Retsat)
HGL: 
101708622(Retsat)
TUP: 
102474082(RETSAT)
CFA: 
483083(RETSAT)
AML: 
FCA: 
101090345(RETSAT)
PTG: 
102958364(RETSAT)
BTA: 
614455(RETSAT)
BOM: 
102279340(RETSAT)
PHD: 
102318558(RETSAT)
CHX: 
102171615(RETSAT)
OAS: 
101123106(RETSAT)
SSC: 
100519138(RETSAT)
CFR: 
102506909(RETSAT)
BACU: 
103009686(RETSAT)
LVE: 
103068788(RETSAT)
ECB: 
100067379(RETSAT)
MYB: 
102241000(RETSAT)
MYD: 
102764075(RETSAT)
PALE: 
102897460(RETSAT)
MDO: 
SHR: 
OAA: 
GGA: 
426549(RETSAT)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
102369670(RETSAT)
AMJ: 
102576004(RETSAT)
PSS: 
102451524(RETSAT)
CMY: 
ACS: 
XLA: 
494824(retsat)
XTR: 
DRE: 
325922(retsat) 563241 677660(retsatl) 777751
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103183764(retsat)
BFO: 
CIN: 
SPU: 
BMY: 
LOA: 
NVE: 
HMG: 
TAD: 
AQU: 
MBR: 
TPS: 
EHX: 
GTT: 
MAQ: 
HCH: 
DSA: 
DAK: 
HOH: 
SRO: 
SAQ: 
BRM: 
CYP: 
CYN: 
CYH: 
CYJ: 
CPI: 
LBY: 
FJO: 
COC: 
FBC: 
IAG: 
KCR: 
 » show all
Taxonomy
Reference
1  [PMID:15358783]
  Authors
Moise AR, Kuksa V, Imanishi Y, Palczewski K.
  Title
Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase.
  Journal
J. Biol. Chem. 279 (2004) 50230-42.
  Sequence
[mmu:67442]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
879291-21-1

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