KEGG   ENZYME: 1.3.99.23Help
Entry
EC 1.3.99.23                Enzyme                                 
Name
all-trans-retinol 13,14-reductase;
retinol saturase;
RetSat;
(13,14)-all-trans-retinol saturase;
all-trans-retinol:all-trans-13,14-dihydroretinol saturase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With other acceptors
BRITE hierarchy
Sysname
all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase
Reaction(IUBMB)
all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor [RN:R07163]
Reaction(KEGG)
Substrate
all-trans-13,14-dihydroretinol [CPD:C15492];
acceptor [CPD:C00028]
Product
all-trans-retinol [CPD:C00473];
reduced acceptor [CPD:C00030]
Comment
The reaction is only known to occur in the opposite direction to that given above, with the enzyme being specific for all-trans-retinol as substrate. Neither all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers are substrates. May play a role in the metabolism of vitamin A.
Pathway
Retinol metabolism
Orthology
K09516  
all-trans-retinol 13,14-reductase
Genes
HSA: 
54884(RETSAT)
PTR: 
470420(RETSAT)
PPS: 
100980971(RETSAT)
GGO: 
101149338(RETSAT)
PON: 
100433966(RETSAT)
MCC: 
695058(RETSAT)
MMU: 
67442(Retsat)
RNO: 
246298(Retsat)
CFA: 
483083(RETSAT)
AML: 
FCA: 
101090345(RETSAT)
BTA: 
614455(RETSAT)
SSC: 
100519138(RETSAT)
ECB: 
100067379
MDO: 
100030257 100030337(RETSAT)
SHR: 
100921830
OAA: 
100088936
GGA: 
426549(RETSAT)
MGP: 
100544741
TGU: 
101233661
ACS: 
100554362
XLA: 
494824(retsat)
XTR: 
100158500(retsat) 100488563
DRE: 
325922(retsat) 677660(retsatl) 777751
TRU: 
101065125 101078075
OLA: 
101155933
BFO: 
BRAFLDRAFT_119025
CIN: 
100179991
SPU: 
581285
BMY: 
Bm1_02785
NVE: 
NEMVE_v1g183264
HMG: 
100203715
TAD: 
TRIADDRAFT_22982
AQU: 
100636736
MBR: 
MONBRDRAFT_21832
TPS: 
THAPSDRAFT_10254 THAPSDRAFT_11636
MAQ: 
Maqu_0318
HCH: 
HCH_01940
DSA: 
Desal_0539
DAK: 
DaAHT2_1135
HOH: 
Hoch_3011
SRO: 
Sros_4146
SAQ: 
Sare_1053
BRM: 
Bmur_0577
CPI: 
Cpin_1874
LBY: 
Lbys_1480
FJO: 
Fjoh_1077
COC: 
Coch_1995
FBC: 
FB2170_12061
CYP: 
PCC8801_0425
CYN: 
Cyan7425_1174
CYH: 
Cyan8802_0436
CYJ: 
Cyan7822_0323
IAG: 
Igag_1801
KCR: 
Kcr_0408
 » show all
Taxonomy
Reference
1  [PMID:15358783]
  Authors
Moise AR, Kuksa V, Imanishi Y, Palczewski K.
  Title
Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase.
  Journal
J. Biol. Chem. 279 (2004) 50230-42.
  Organism
Mus musculus [GN:mmu]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
879291-21-1
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