KEGG   ENZYME: 1.3.99.34Help
Entry
EC 1.3.99.34                Enzyme                                 

Name
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (donor);
AF0464 (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With other acceptors
BRITE hierarchy
Sysname
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate:acceptor oxidoreductase
Reaction(IUBMB)
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + acceptor = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + reduced acceptor [RN:R10331]
Reaction(KEGG)
Substrate
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate [CPD:C20518];
acceptor [CPD:C00028]
Product
2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate;
reduced acceptor [CPD:C00030]
Comment
A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol 1-phosphate with comparable activity. Geranylgeranyl diphosphate is partially reduced to phytyl diphosphate with 10% of the activity (cf. EC 1.3.1.83, geranylgeranyl diphosphate reductase). Unlike EC 1.3.1.101, 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], the enzyme shows no activity with NADPH. In vitro the enzyme can utilize sodium dithionite as the electron donor.
History
EC 1.3.99.34 created 2013
Pathway
Glycerophospholipid metabolism
Orthology
K17830  
digeranylgeranylglycerophospholipid reductase
Genes
TPZ: 
POM: 
IAL: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MBA: 
MMA: 
MMAZ: 
MBU: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MEZ: 
RCI: 
RCIX2051(bchP)
MER: 
MTH: 
MMG: 
MST: 
MSI: 
MRU: 
MEB: 
MEL: 
MEW: 
METH: 
MFV: 
MKA: 
MAX: 
AFU: 
AF0464(chlP-1)
APO: 
AVE: 
AST: 
FPL: 
TAC: 
TVO: 
PTO: 
FAC: 
TAR: 
PHO: 
PAB: 
PAB0109(bchP)
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TGA: 
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
ABI: 
ACF: 
VMO: 
TPE: 
THB: 
NMR: 
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NKR: 
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 » show all
Taxonomy
Reference
1  [PMID:17288560]
  Authors
Murakami M, Shibuya K, Nakayama T, Nishino T, Yoshimura T, Hemmi H
  Title
Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus.
  Journal
FEBS. J. 274 (2007) 805-14.
  Organism
Archaeoglobus fulgidus
  Sequence
[afu:AF0464]
Reference
2  [PMID:18375567]
  Authors
Sato S, Murakami M, Yoshimura T, Hemmi H
  Title
Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl donor, not a dead-end product.
  Journal
J. Bacteriol. 190 (2008) 3923-9.
Reference
3  [PMID:21515284]
  Authors
Sasaki D, Fujihashi M, Iwata Y, Murakami M, Yoshimura T, Hemmi H, Miki K
  Title
Structure and mutation analysis of archaeal geranylgeranyl reductase.
  Journal
J. Mol. Biol. 409 (2011) 543-57.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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