KEGG   ENZYME: 1.4.1.12Help
Entry
EC 1.4.1.12                 Enzyme                                 

Name
2,4-diaminopentanoate dehydrogenase;
2,4-diaminopentanoic acid C4 dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)
Reaction(IUBMB)
2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+ [RN:R04200 R04201]
Reaction(KEGG)
Substrate
2,4-diaminopentanoate [CPD:C03943];
H2O [CPD:C00001];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
2-amino-4-oxopentanoate [CPD:C03341];
NH3 [CPD:C00014];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate.
History
EC 1.4.1.12 created 1976
Pathway
Lysine degradation
Arginine and proline metabolism
D-Arginine and D-ornithine metabolism
Reference
1  [PMID:4684685]
  Authors
Somack R, Costilow RN.
  Title
2,4-diaminopentanoic acid C 4  dehydrogenase. Purification and properties of the protein.
  Journal
J. Biol. Chem. 248 (1973) 385-8.
  Organism
Clostridium sticklandii
Reference
2
  Authors
Stadtman, T.C.
  Title
Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase).
  Journal
Adv. Enzymol. Relat. Areas Mol. Biol. 38 (1973) 441-445.
Reference
3  [PMID:4394942]
  Authors
Tsuda Y, Friedmann HC.
  Title
Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide.
  Journal
J. Biol. Chem. 245 (1970) 5914-26.
  Organism
Clostridium sticklandii
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
39346-26-4

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